Recruiting

Functional Mobility

Sponsor:

VA Office of Research and Development

Code:

NCT06850350

Conditions

Post-acute Sequelae of SARS-CoV-2 Infection

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Growing evidence indicates that many people who have chronic post-acute sequelae of SARS-CoV-2 infection (PASC) will experience ongoing neurological and musculoskeletal impairment that can affect gait and balance. Identifying the factors contributing to these impairments and how they influence functional mobility is the first step towards creating effective evaluation and treatment protocols. In this study the investigators will examine cognition, vision, proprioception, muscle strength, gait and balance in persons with and without PASC to understand how PASC may impact functional mobility through a cognitive-sensorimotor lens. Gait and balance will be studied in environments that stress cognitive and sensory abilities. Study outcomes will be critical for the development of evidence-based Veteran Health Administration diagnostic and standard-of-care protocols to address gait and balance dysfunction in Veterans with PASC for restoring their functional mobility and independence.

Conditions

Post-acute Sequelae of SARS-CoV-2 Infection

Study ID

NCT06850350

Start date

Apr 1, 2026

Status verified date

May, 2026

Completion date

Dec 31, 2030

Anticipated

Primary completion date

Dec 31, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Older than 18 years of age
  • Positive PCR or Rapid COVID-19 test in the past
  • Onset of COVID-19 illness greater than 3 months prior to their participation in the study
  • Self-reported ability to walk 10 meters with or without external assistance prior to COVID-19 illness

Exclusion Criteria:

  • Presence of severe cardiovascular and pulmonary disease and/or neurological and musculoskeletal disorders unrelated to COVID-19 (e.g., amputation, stroke, spinal cord injury)
  • Cognitive impairments precluding ability to provide informed consent.
  • Severe acute COVID-19 infection requiring hospitalization or diagnosed post-intensive care syndrome.
  • Presence of musculoskeletal, inflammatory, or neurological conditions mimicking Long COVID-19 symptoms (e.g., concussion within last 5 years, Chronic fibromyalgia, Myofascial pain syndrome, etc.)

Study Design

Enrollment

136 participants

Anticipated

Interventions and Outcome Measures

Arms

Control

Adults who previously contracted Covid-19 but do not have Long-COVID.

Experimental

Adults who previously contracted Covid-19 and have Long-COVID.

Primary outcome measure

  • NIH Toolbox Cognition Battery [ Time Frame: During single session of two hours ]
  • Joint position sense proprioception [ Time Frame: During single session of two hours ]
  • King-Devick Test [ Time Frame: During single session of two hours ]
  • Maximum voluntary muscle strength [ Time Frame: During single session of two hours ]
  • Dual task gait cost [ Time Frame: During single session of two hours ]
  • Modified Clinical Test of Sensory Interaction on Balance [ Time Frame: During single session of two hours ]

Central Contacts and Locations

Central contacts

Matthew J Major, PhD

(312) 569-6166Matthew.Major2@va.gov

Keith E Gordon, PhD

(708) 202-8387Keith.Gordon2@va.gov

Locations

Jesse Brown VA Medical Center, Chicago, IL

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Matthew J Major, PhD

312-569-6166Matthew.Major2@va.gov

Karen M Lenehan

(312) 569-6343Karen.Lenehan@va.gov

Principal Investigator:

Matthew J. Major, PhD

More Information

Sponsor

VA Office of Research and Development

Last update posted

May 8, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by VA Office of Research and Development on 2026-05-08.