Recruiting
Early Phase 1

Hyperpolarized Xe129-MRI

Sponsor:

University of Virginia

Code:

NCT06853145

Conditions

Idiopathic Pulmonary Fibrosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Hyperpolarized Xe129

Study Details

Brief summary:

Idiopathic pulmonary fibrosis has a poor prognosis with limited treatment options. The Investigator hypothesize hyperpolarized Xe129-MRI can be performed in patients with IPF and repeated over time which will detect deficiencies related to perfusion in the lung.

Conditions

Idiopathic Pulmonary Fibrosis

Study ID

NCT06853145

Start date

May 1, 2025

Status verified date

Apr, 2025

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Able to provide informed consent 18 years of age or greater Clinical diagnosis of IPF

Exclusion Criteria:

  • Continuous oxygen use at home
  • Oxygen saturation less than 92% on the day of MRI procedure
  • Pregnancy or lactation
  • Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning. Subjects with any implanted device that cannot be verified as MRI compliant will be excluded.
  • History of congenital cardiac disease, chronic renal failure, or cirrhosis. • Chest circumference greater than that of the xenon MR and/or helium coil. The circumference of the coil is approximately 42 inches.
  • Inability to understand simple instructions or to hold still for approximately 10-15 seconds.
  • History of respiratory infection within 2 weeks prior to the MR scan
  • History of MI, stroke and/or poorly controlled hypertension.

Study Design

Enrollment

6 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

other: IPF subjects

IPF subjects will undergo Xe-129 MRI

Interventions

Hyperpolarized Xe129

Hyperpolarized Xe129-MRI: Patients will undergo hyperpolarized Xe129-MRI at the University of Virginia Radiology Imaging Core (Charlottesville, VA, USA). The entire procedure visit takes approximately 3 hours based on our team's experience.

Primary outcome measure

  • Measuring the ventilation effect of HXe129 MRI for IPF subjects [ Time Frame: Up to 24 hours post MR Imaging ]

Central Contacts and Locations

Central contacts

Roselove Asare, MA

4342436074rnn3b@uvahealth.org

Locations

Snyder Building 480 Ray C. Hunt Drive

Recruiting

Charlottesville, Virginia, United States, 22908

Contacts

Roselove Asare, MA

434-243-6074rnn3b@uvahealth.org

Carol Bampoe, BS

4342439634cb3ff@uvahealth.org

Principal Investigator:

John Kim, MD

More Information

Sponsor

University of Virginia

Last update posted

Jul 9, 2025

Last verified

Apr, 2025

Keywords

  • Hyperpolarized Xenon-129 gas with MRI

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Virginia on 2025-07-09.