Recruiting
Phase 1

Smoked Cannabis

Sponsor:

UCLA

Code:

NCT06859723

Conditions

Abuse Cannabis

Pain

Pharmacokinetics

Eligibility Criteria

Sex: All

Age: 21 - 55

Healthy Volunteers: Accepted

Interventions

Placebo Comparator: Placebo

Low dose THC

High dose THC

Study Details

Brief summary:

The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.

Conditions

Abuse Cannabis

Pain

Pharmacokinetics

Study ID

NCT06859723

Start date

Jul 3, 2025

Status verified date

Sep, 2026

Completion date

Jul 1, 2028

Anticipated

Primary completion date

Jul 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 55

Healthy Volunteers: Accepted

Inclusion Criteria:

  • • Male or non-pregnant and non-lactating females aged 21-55 years

  • Report cannabis smoking near daily
  • Not currently seeking treatment for their cannabis use
  • Have a Body Mass Index from 18.5 - 34kg/m2.
  • Able to perform all study procedures
  • Must be using a contraceptive (hormonal or barrier methods)

Exclusion Criteria:

  • Meeting DSM-V criteria for any substance use disorder other than cannabis, nicotine, caffeine
  • Do not have positive urine toxicology for cannabis use during screening
  • Evidence of severe psychiatric illness (e.g. mood or anxiety disorder with functional impairment or suicide risk, schizophrenia) judged by the study physician (and PI) to put the participant at greater risk of experiencing adverse events due to completion of study procedures, interfere with their ability to participate in the study, or their capacity to provide informed consent.
  • Report using other illicit drugs in the prior 4 weeks
  • Current predominant licit use of medical cannabis, prescription analgesics, or any medications that may affect study outcomes
  • Current pain
  • Pregnancy
  • Currently enrolled in another research protocol
  • Not using a contraceptive method (hormonal or barrier methods)
  • Insensitivity to the cold water stimulus of the Cold Pressor Test
  • Any disorders that might make cannabis administration hazardous as determined by evaluation physician after review of all medical assessments along with medical history.
  • Not able to speak and read English

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

placebo comparator: Placebo Comparator: Placebo

0 mg THC

active comparator: Low dose THC

50 mg THC

active comparator: High dose THC

100 mg THC

Interventions

Placebo Comparator: Placebo

Placebo

Low dose THC

Smoked low dose THC

High dose THC

Smoked high dose THC

Primary outcome measure

  • Subject-rated drug effects of abuse liability [ Time Frame: 3 hours ]
  • Analgesia as measured using the Cold Pressor Test [ Time Frame: 3 hours ]

Central Contacts and Locations

Central contacts

Ziva Cooper, PhD

310-206-9942cannabislab@mednet.ucla.edu

Vincent Acebo

310-983-3417vacebo@mednet.ucla.edu

Locations

UCLA Center for Cannabis and Cannabinoids

Recruiting

Los Angeles, California, United States, 90095

Contacts

Vincent Acebo

310-983-3417vacebo@mednet.ucla.edu

More Information

Sponsor

University of California, Los Angeles

Last update posted

Sep 4, 2026

Last verified

Sep, 2026

Keywords

  • THC
  • Cannabis

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of California, Los Angeles on 2026-09-04.