Recruiting

Microvascular Health

Sponsor:

Virginia Commonwealth University

Code:

NCT06860698

Conditions

E-Cig Use

Eligibility Criteria

Sex: All

Age: 18 - 29

Healthy Volunteers: Accepted

Interventions

E-cig use

Study Details

Brief summary:

The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds. For one of the tests, iontophoresis, the drug's use will be stored and handled as described by the approved IND and non-IDS plan.

Conditions

E-Cig Use

Study ID

NCT06860698

Start date

Jul 14, 2023

Status verified date

Sep, 2026

Completion date

Sep 28, 2026

Anticipated

Primary completion date

Sep 28, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 29

Healthy Volunteers: Accepted

e-Cig users arm

Inclusion Criteria:

  • Between 18 and 29 years of age
  • Used e-cigarettes with nicotine (≥3 times/week for ≥6 months)

Exclusion Criteria:

  • 17 years old and younger or 30 years old or older.
  • Former combustible tobacco user/ former smoker
  • Use of cigarettes for 15 days or more in the past 60 days
  • Use of other tobacco products (cigars, hookah, smokeless), marijuana and/or illicit or prescription drugs weekly or more frequently in the past 60 days
  • Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders
  • Disorder or use of medication that affects cardiopulmonary health
  • Evidence of pregnancy or current nursing

Non e-Cig using arm

Inclusion

\- Between 18 and 29 years of age

Exclusion

  • 17 years old and younger or 30 years old and older
  • Use of cigarettes or other tobacco products more than 50 times in their lifetime.
  • Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders
  • Disorder or use of medication that affects cardiopulmonary health
  • Evidence of pregnancy or current nursing

Study Design

Enrollment

44 participants

Anticipated

Interventions and Outcome Measures

Arms

Chronic e-cigs users

Used e-cigarettes with nicotine (≥3 times/week for ≥6 months)

Never Users

Use of cigarettes or other tobacco products less than 50 times in their lifetime.

Interventions

E-cig use

Based on e-cigarette usage, participants will be divided into those who used e-cigarettes and those who did not use e-cigarettes

Primary outcome measure

  • Endothelial dependent dilation [ Time Frame: Participation is one week ]
  • Neurogenic response [ Time Frame: Participation is one week ]

Central Contacts and Locations

Central contacts

Paula Rodriguez Miguelez

(804) 396-4498prodriguezmig@vcu.edu

Locations

Virginia Commonwealth University

Recruiting

Richmond, Virginia, United States, 23298

Contacts

Paula Rodriguez Miguelez

804-396-4498prodriguezmig@vcu.edu

More Information

Sponsor

Virginia Commonwealth University

Last update posted

Sep 9, 2026

Last verified

Sep, 2026

Keywords

  • Microvascular Health

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Virginia Commonwealth University on 2026-09-09.