Recruiting

Observational Study

Sponsor:

Johns Hopkins University

Code:

NCT06861868

Conditions

Obesity and Overweight

Eligibility Criteria

Sex: All

Age: 7 - 12

Healthy Volunteers: Accepted

Interventions

fMRI cue reactivity task

fMRI go no go task

Ad libitum meal test

Eating in the absence of hunger test

Study Details

Brief summary:

The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function. This data is collected in a sub-sample of RESONANCE, a large study of families of children from infancy through childhood. The results will lay foundations for the development of early interventions to prevent or treat obesity.

Conditions

Obesity and Overweight

Study ID

NCT06861868

Start date

Dec 2, 2024

Status verified date

May, 2026

Completion date

Mar 31, 2029

Anticipated

Primary completion date

Mar 31, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 7 - 12

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Participants from the RESONANCE cohort are eligible if the participant will reach 7-12 years of age during the proposed project period and have no food allergies.

Exclusion Criteria:

  • Exclusion criteria for RESONANCE include:

1. In utero exposure to alcohol, cigarette, or illicit substances;
2. First trimester fetal US abnormalities;
3. Complicated pregnancy (e.g., pre-eclampsia);
4. Complicated delivery, including APGAR scores less than 8 and/or neonatal intensive care unit (NICU) admission;
5. History of neurological (e.g., epilepsy), psychiatric (e.g., anxiety or depression requiring treatment with medication) or developmental disorder (e.g., autism spectrum disorder (ASD), dyslexia);
6. Contraindications for MRI including metal in the body, claustrophobia.

Study Design

Enrollment

210 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

other: Single arm

Single arm

Interventions

fMRI cue reactivity task

Measures effect of food and non-food cues on brain activation

fMRI go no go task

Measures effect of food and non-food cues on inhibitory responses and brain activation

Ad libitum meal test

Measures effect of exposure to multi-item buffet meal on food intake

Eating in the absence of hunger test

Measures effect of exposure to palatable snacks on food intake

Primary outcome measure

  • Meal test intake as assessed by total kilocalories consumed [ Time Frame: Day 1 ]
  • Weight/adiposity as assessed by BMI [ Time Frame: Day 1 ]
  • Food-related reward as assessed by food-related delay discounting task [ Time Frame: Day 1 ]
  • Food-related cognitive control as assessed by food-related go/no-go task [ Time Frame: Day 1 ]
  • Functioning in brain appetite circuits as assessed by cue reactivity task [ Time Frame: During MRI procedure ]
  • Functioning in brain appetite circuits as assessed by cognitive control task [ Time Frame: During MRI procedure ]

Central Contacts and Locations

Central contacts

Susan Carnell, PhD

410-955-7192susan.carnell@jhmi.edu

Viren D'Sa, MD

312-371-4178viren_dsa@brown.edu

Locations

Rhode Island Hospital

Recruiting

Providence, Rhode Island, United States, 02903

Contacts

Viren D'Sa, MD

312-371-4178viren_dsa@brown.edu

Daphne Koinis-Mitchell, PhD

401-793-8632daphne_koinis-mitchell@brown.edu

Principal Investigator:

Viren D'Sa, MD

More Information

Sponsor

Johns Hopkins University

Last update posted

May 7, 2026

Last verified

May, 2026

Keywords

  • obesity
  • overweight
  • pediatric
  • eating behavior
  • appetite
  • neuroimaging
  • magnetic resonance imaging
  • brain development

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-05-07.