Recruiting

Observational Study

Sponsor:

Emory University

Code:

NCT06865820

Conditions

Epilepsy

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Project UPLIFT

Study Details

Brief summary:

This study tests Project Using Practice and Learning to Increase Favorable Thoughts (UPLIFT) which is a Mindfulness-based Cognitive Behavioral Therapy program teaching participants with epilepsy methods that include challenging thoughts, behavioral activation, coping, problem-solving, and mindfulness, for well-being and costs. Project UPLIFT is delivered as weekly sessions over 8 weeks.

Conditions

Epilepsy

Study ID

NCT06865820

Start date

Mar 24, 2025

Status verified date

Aug, 2026

Completion date

Aug, 2027

Anticipated

Primary completion date

Aug, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults 18 years or older
  • Diagnosis of epilepsy (self-reported by patient)
  • Can speak English
  • Has access to a phone or computer

Exclusion Criteria:

  • Inability to cognitively participate

Study Design

Enrollment

60 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Project UPLIFT

Adults with epilepsy participating in a group-based program for 8 weeks. Project UPLIFT is designed to increase knowledge and skills, decrease depressive symptoms and improve quality of life.

Interventions

Project UPLIFT

Project UPLIFT is a Mindfulness-based Cognitive Behavioral Therapy program teaching participants methods that include challenging thoughts, behavioral activation, coping, problem-solving, and mindfulness. The program is group-based and provides weekly sessions, delivered remotely via telephone or video conferencing platform, over an 8-week period.

Primary outcome measure

  • Patient Health Questionnaire (PHQ-8) Score [ Time Frame: Baseline, Month 3, Month 6 ]
  • Quality of Life in Epilepsy (QOLIE-10) Score [ Time Frame: Baseline, Month 3, Month 6 ]
  • Quality of Patient-Reported Outcomes Measurement Information System (PROMIS): PROMIS-Preference (PROPr) Score [ Time Frame: Baseline, Month 3, Month 6 ]

Central Contacts and Locations

Central contacts

Cam Escoffery, PhD, MPH

404-727-4701cescoff@emory.edu

Katie Bullinger, MD, PhD

404-778-3444

Locations

Rollins School of Public Health

Recruiting

Atlanta, Georgia, United States, 30322

More Information

Sponsor

Emory University

Last update posted

Aug 7, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Emory University on 2026-08-07.