Recruiting

Peanuts

Sponsor:

Georgia State University

Code:

NCT06867198

Conditions

Prediabetes

Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)

Cognition

Microvascular Function

Gut Microbiota

Eligibility Criteria

Sex: All

Age: 20 - 59

Healthy Volunteers: Not accepted

Interventions

Peanuts

Study Details

Brief summary:

The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially diverse prediabetes population.

Conditions

Prediabetes

Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)

Cognition

Microvascular Function

Gut Microbiota

Study ID

NCT06867198

Start date

Mar 6, 2025

Status verified date

Sep, 2026

Completion date

Sep, 2027

Anticipated

Primary completion date

Sep, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 20 - 59

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • men and women
  • 20-59 years of age
  • BMI: 24.5 - 35.5 kg/m\^2
  • Prediabetes (fasting blood glucose levels 100-125 mg/dL and/or HbA1c between 5.7-6.4%)
  • Ability to give consent

Exclusion Criteria:

  • Allergies to peanuts and peanut products
  • Use of insulin, antidiabetic, antibiotics, and anti-inflammatory drugs
  • Active cancer, gastrointestinal, renal, cardiovascular, thyroid, and neurological diseases or severe head injury
  • Smoking
  • Consumes greater than 2 alcoholic beverages per day
  • Consumes antioxidant, probiotic, and prebiotic supplements
  • Pregnant or Lactating
  • Actively participating in a weight loss program

MRI Exclusion Criteria:

  • Certain neurological disorders (e.g., uncontrolled seizure disorders)
  • Braces on their teeth, a cardiac pacemaker; hearing aid; other metal in the body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects

Study Design

Enrollment

72 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Peanut

43 g of peanut butter (1snack cup) 3 x/week, 42 g of dry roasted peanuts (1/3 of a cup) 3x/week, or 56 g of peanut flour 1x/week for 6 months

no intervention: Control

No intervention

Interventions

Peanuts

43 g of peanut butter (1 snack cup) 3 x/week, 42 g of dry roasted peanuts (1/3 of a cup) 3x/week, or 56 g of peanut flour 1x/week for 6 months.

Primary outcome measure

  • Blood Glucose [ Time Frame: Baseline, 3 months, and 6 months ]
  • Glycosylated hemoglobin [ Time Frame: Baseline, 3 months, and 6 months ]

Central Contacts and Locations

Central contacts

Rafaela G Feresin, PhD

404-413-1233peanuts@gsu.edu

Locations

Georgia State University

Recruiting

Atlanta, Georgia, United States, 30303

Contacts

Rafaela G Feresin, PhD

404-413-1233peanuts@gsu.edu

Principal Investigator:

Rafaela G Feresin, PhD

More Information

Sponsor

Georgia State University

Last update posted

Sep 2, 2026

Last verified

Sep, 2026

Keywords

  • prediabetes
  • peanuts
  • functional foods
  • nuts
  • metabolic health
  • insulin resistance
  • type II diabetes
  • microvascular function
  • dietary intervention
  • cognitive function
  • vascular function
  • neuroimaging
  • endothelial function
  • cardiovascular health
  • gut microbiota

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Georgia State University on 2026-09-02.