Recruiting
Phase 3

Remibrutinib vs. Dupilumab

Sponsor:

Novartis Pharmaceuticals

Code:

NCT06868212

Conditions

Chronic Spontaneous Urticaria (CSU)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Remibrutinib

Remibrutinib matching placebo

Dupilumab

Placebo solution for injection

Study Details

Brief summary:

This is a US, multi-center, randomized, double-blind, double-dummy, Phase 3b study to evaluate efficacy of remibrutinib (25 mg twice daily \[b.i.d.\] by mouth \[p.o.\]) compared to dupilumab (600 mg loading dose administered subcutaneously (s.c.) followed by 300 mg every 2 weeks s.c.) at early timepoints (4 weeks and earlier), when administered as an add-on treatment to second generation H1-antihistamines (sgH1-AH) (standard label dose as background therapy) in adult US participants with moderate to severe chronic spontaneous urticaria (CSU) inadequately controlled by sgH1-AHs.

Conditions

Chronic Spontaneous Urticaria (CSU)

Study ID

NCT06868212

Start date

Jul 11, 2025

Status verified date

Aug, 2026

Completion date

May 17, 2027

Anticipated

Primary completion date

Feb 22, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults ≥ 18 years of age at the time of signing the informed consent
  • CSU duration for ≥ 6 months prior to screening (defined as the onset of CSU determined by the Investigator based on all available supporting documentation)
  • Diagnosis of CSU inadequately controlled by sgH1-AH at the time of randomization, defined as:
  • The presence of itch and hives for ≥ 6 consecutive weeks prior to screening despite the use of sgH1-AH during the 7 days prior to randomization (Day 1):
  • UAS7 score (range, 0-42) ≥ 16, and
  • ISS7 score (range, 0-21) ≥ 6, and
  • HSS7 score (range, 0-21) ≥ 6
  • Documentation of hives within 3 months before randomization (either at screening and/or at randomization); or documented in the participants medical history
  • Willing and able to complete an Urticaria Patient Daily Diary (UPDD) for the duration of the study and adhere to the study protocol
  • Participants must not have had more than one missing UPDD entry (either morning or evening) in the 7 days prior to randomization (Day 1)

Exclusion Criteria:

  • Previous use of remibrutinib or other bruton's tyrosine kinase (BTK) inhibitors
  • Previous use of dupilumab
  • Evidence of clinically significant cardiovascular (such as but not limited to myocardial infarction, unstable ischemic heart disease, NYHA Class III/IV left ventricular failure, arrhythmia and uncontrolled hypertension within 12 months prior to Visit 1), neurological, psychiatric, pulmonary, renal, hepatic (past history or current), endocrine or metabolic disorder, or immunodeficiency that, in the investigator's opinion, would compromise the safety of the participant, interfere with the interpretation of the study results or otherwise preclude participation or protocol adherence of the participant.
  • Evidence of hematological disorders (including coagulation disorders or significant bleeding risk)
  • History or evidence of gastrointestinal disease (including gastrointestinal bleeding, e.g., in association with use of nonsteroidal anti-inflammatory drugs (NSAID), that was clinically relevant (e.g., where intervention was indicated or requiring hospitalization or blood transfusion)
  • Requirement for anti-platelet medication, except for acetylsalicylic acid up to 100 mg/d or clopidogrel up to 75 mg/d. The use of dual anti-platelet therapy (e.g., acetylsalicylic acid + clopidogrel) is prohibited.
  • Requirement for anticoagulant medication (for example, warfarin or Novel Oral Anti-Coagulants \[NOAC\])
  • History or current hepatic disease including but not limited to acute or chronic hepatitis, cirrhosis or hepatic failure or hepatic parameters at screening: Aspartate Aminotransferase (AST)/ Alanine Aminotransferase (ALT) levels more than 1.5x ULN or International Normalized Ratio (INR) > 1.5 at screening

Study Design

Enrollment

400 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Treatment group 1: Remibrutinib + Placebo

Remibrutinib tablet (25 mg b.i.d. p.o.) + placebo solution for injection in pre-filled syringe (2 s.c. injections at baseline and then 1 s.c. injection every other week \[Weeks 2-10\])

active comparator: Treatment group 2: Dupilumab + remibrutinib matching placebo

Dupilumab pre-filled syringe (600 mg loading dose \[2 x 300 mg dupilumab s.c. injection\] at baseline visit followed by dupilumab 300 mg s.c. injection every other week \[Weeks 2-10\]) + remibrutinib matching placebo tablet (1 tablet b.i.d. p.o.)

Interventions

Remibrutinib

Film-coated tablet, oral administration, 25 mg b.i.d.

Remibrutinib matching placebo

Film-coated tablet, oral administration, b.i.d.

Dupilumab

Solution for injection in pre-filled syringe 600 mg loading dose followed by 300 mg dose every 2 weeks

Placebo solution for injection

Solution for injection in pre-filled syringe every 2 weeks

Primary outcome measure

  • Absolute change from baseline in Weekly Urticaria Activity Score (UAS7) at Week 4 [ Time Frame: Baseline, Week 4 ]

Central Contacts and Locations

Central contacts

Locations

Allervie Clinical Research

Recruiting

Birmingham, Alabama, United States, 35209

Contacts

Principal Investigator:

Weily Soong

Cahaba Derm and skin hlth ctr 27

Recruiting

Birmingham, Alabama, United States, 35244

Contacts

Principal Investigator:

Vlada Groysman

Research Solutions of Arizona

Recruiting

Litchfield Park, Arizona, United States, 85340

Contacts

Principal Investigator:

Connie Hsu

Peak Dermatology

Recruiting

Payson, Arizona, United States, 85541

Contacts

Principal Investigator:

Christopher Rex

Premier Allergy Asthma And Immunology

Recruiting

Phoenix, Arizona, United States, 85032

Contacts

Principal Investigator:

Kiranjit Khalsa

Orso Health

Recruiting

Scottsdale, Arizona, United States, 85254

Contacts

Principal Investigator:

Jennifer Hill

Clin Trial Inst of Northwest AR

Recruiting

Fayetteville, Arkansas, United States, 72703

Contacts

Principal Investigator:

Mildred Clifton

Acuro Research Inc

Recruiting

Little Rock, Arkansas, United States, 72205

Contacts

Principal Investigator:

Karl Sitz

First OC Dermatology

Recruiting

Fountain Valley, California, United States, 92708

Contacts

Principal Investigator:

Vivian Laquer

Ctr for Dermatology Clinical Res

Recruiting

Fremont, California, United States, 95438

Contacts

Principal Investigator:

Sunil Dhawan

Allergy and Asthma Specialists Group

Recruiting

Huntington Beach, California, United States, 92647

Contacts

Principal Investigator:

Steven F Weinstein

Orso Health

Recruiting

Long Beach, California, United States, 90808

Contacts

Principal Investigator:

Steven M Meltzer

Ark Clinical Research

Recruiting

Long Beach, California, United States, 90815

Contacts

Principal Investigator:

Kenneth Kim

California Allergy and Asthma Medical Group

Recruiting

Los Angeles, California, United States, 90025

Contacts

Principal Investigator:

Ricardo Tan

Dermatology Research Associates

Recruiting

Los Angeles, California, United States, 90045

Contacts

Principal Investigator:

Howard Lee Sofen

One Of A Kind Clinical Research

Recruiting

Napa, California, United States, 94558

Contacts

Principal Investigator:

Sam Ahn

Stanford University Medical Center

Recruiting

Palo Alto, California, United States, 94304

Contacts

Principal Investigator:

Meng Chen

Empire Clinical Research

Recruiting

Pomona, California, United States, 91767

Contacts

Principal Investigator:

Radhika Shah

Allergy and Asthma Consultants

Recruiting

Redwood City, California, United States, 94063

Contacts

Principal Investigator:

Brian Lipson

Norcal Clinical Research

Recruiting

Rocklin, California, United States, 95765

Contacts

Principal Investigator:

Maulik Dhanda

Peninsula Research Associates

Recruiting

Rolling Hills Estates, California, United States, 90274

Contacts

Principal Investigator:

Lawrence D Sher

Integrative Skin Science and Res

Recruiting

Sacramento, California, United States, 95815

Contacts

Principal Investigator:

Raja Sivamani

UC Davis Neuromuscular Research Center

Recruiting

Sacramento, California, United States, 95817

Contacts

Principal Investigator:

Emanual Maverakis

Therapeutics Clinical Research

Recruiting

San Diego, California, United States, 92123

Contacts

Principal Investigator:

Neal Bhatia

Dermatology Institute and Skin Care

Recruiting

Santa Monica, California, United States, 90403

Contacts

Principal Investigator:

Paul Yamauchi

Integrated Research of Inland Inc

Recruiting

Upland, California, United States, 91786

Contacts

Principal Investigator:

Amit I Patel

Allergy and Asthma Clin Res Inc

Recruiting

Walnut Creek, California, United States, 94598

Contacts

Principal Investigator:

Joshua S Jacobs

University of Colorado Hospital - Aurora

Recruiting

Aurora, Colorado, United States, 80045

Contacts

Principal Investigator:

Jenny Stitt

Asthma and Allergy Associates P C

Recruiting

Colorado Springs, Colorado, United States, 80907

Contacts

Principal Investigator:

Daniel Soteres

Colorado ENT and Allergy

Recruiting

Colorado Springs, Colorado, United States, 80909

Contacts

Principal Investigator:

Eric Caplan

Skylight Health Res Inc Color Spr

Recruiting

Colorado Springs, Colorado, United States, 80917

Contacts

Principal Investigator:

David Greenstein

UCONN Health Dermatology

Recruiting

Farmington, Connecticut, United States, 06030-2840

Contacts

Ektor Rafti

erafti@uchc.edu

Principal Investigator:

Jun Lu

Howard University Hospital Division of Geriatrics

Recruiting

Washington D.C., District of Columbia, United States, 20059

Contacts

Principal Investigator:

Carla Davis

Florida Ctr Allergy Asthma Research

Recruiting

Aventura, Florida, United States, 33180

Contacts

Principal Investigator:

Ileana Rodicio

Florida Ctr Allergy Asthma Research

Recruiting

Aventura, Florida, United States, 33180

Contacts

Principal Investigator:

Jaime Landman

Skin Care Research Inc

Recruiting

Boca Raton, Florida, United States, 33486

Contacts

Principal Investigator:

Ann Reed

Omnicure Clinical Research

Recruiting

Doral, Florida, United States, 33172

Contacts

Principal Investigator:

Alan Kaufman

FXM Clinical Research Ft Laud

Recruiting

Fort Lauderdale, Florida, United States, 33308

Contacts

Principal Investigator:

Igor Chaplik

Skin Care Research LLC

Recruiting

Hollywood, Florida, United States, 33021

Contacts

Principal Investigator:

Eduardo Weiss

Jacksonville Center for Clinical Research

Recruiting

Jacksonville, Florida, United States, 32216

Contacts

Principal Investigator:

Steve Dorman

University of MiamiHealth System

Recruiting

Miami, Florida, United States, 33125

Contacts

Felierix Castro Palmero

fxc609@med.miami.edu

Principal Investigator:

Gil Yosipovitch

FXM Clinical Res Miami LLC

Recruiting

Miami, Florida, United States, 33175

Contacts

Principal Investigator:

Hector Wiltz

Miami Dade Medical Research

Recruiting

Miami, Florida, United States, 33176

Contacts

Principal Investigator:

Vicente Chavarria

FXM Clin Res Miramar LLC

Recruiting

Miramar, Florida, United States, 33027

Contacts

Principal Investigator:

Francisco Flores

Ziaderm Research LLC

Recruiting

North Miami Beach, Florida, United States, 33162

Contacts

Principal Investigator:

Tory Sullivan

AllerVie Health

Recruiting

Panama, Florida, United States, 32405

Contacts

Principal Investigator:

Maxcie Sikora

Sarasota Clinical Research

Recruiting

Sarasota, Florida, United States, 34233

Contacts

Principal Investigator:

Hugh Harmon Windom

Lenus Research and Med Group LLC

Recruiting

Sweetwater, Florida, United States, 33172

Contacts

Principal Investigator:

John Niven

Olympian Clinical Research

Recruiting

Tampa, Florida, United States, 33609

Contacts

Principal Investigator:

Matthew Zook

Asthma Allergy Immunology Clin Res

Recruiting

Tampa, Florida, United States, 33613

Contacts

Principal Investigator:

Amber N Pepper

Conquest Research

Recruiting

Winter Park, Florida, United States, 32789

Contacts

Principal Investigator:

Michael Wangia

AllerVie Clin Res Columbus GA

Recruiting

Columbus, Georgia, United States, 31904

Contacts

Principal Investigator:

Robert R Chrzanowski

Cleaver Medical Group

Recruiting

Cumming, Georgia, United States, 30040

Contacts

Principal Investigator:

Weston Waxweiler

Southeast Dermatology Specialists

Recruiting

Douglasville, Georgia, United States, 30135

Contacts

Taylor Harrell

tharrell@sedsderm.com

Principal Investigator:

Firas Hougeir

Aeroallergy Research Laboratories

Recruiting

Savannah, Georgia, United States, 31406

Contacts

Principal Investigator:

Bruce Finkel

The Allergy Group-Meridian Clinic

Recruiting

Meridian, Idaho, United States, 83642

Contacts

Principal Investigator:

Neetu Talreja

NW Uni C and T Sciences Ins

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Principal Investigator:

Anju T Peters

Rush University Medical Center

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Principal Investigator:

James N. Moy

Midwest Allergy Sinus Asthma SC

Recruiting

Normal, Illinois, United States, 61761

Contacts

Principal Investigator:

Dareen D Siri

Clinical Res Ctr of S Illinois

Recruiting

O'Fallon, Illinois, United States, 62269

Contacts

Principal Investigator:

Patrick Win

Asthma and Allergy Center of Chicago S C

Recruiting

River Forest, Illinois, United States, 60305

Contacts

Principal Investigator:

Rachna Shah

Endeavor Health Clinical Trials Center

Recruiting

Skokie, Illinois, United States, 60077

Contacts

Principal Investigator:

Giselle Mosnaim

Accellacare Duly Health and Care

Recruiting

Wheaton, Illinois, United States, 60189

Contacts

Principal Investigator:

James Herrmann

Deaconess Clin Allerg Res Inst

Recruiting

Evansville, Indiana, United States, 47715

Contacts

Principal Investigator:

Anne Mclaughlin

Southern IN Clinical Trials

Recruiting

New Albany, Indiana, United States, 47150

Contacts

Misty Humphress

mhumphress@soinct.com

Principal Investigator:

Megan Landis

McFarland Clinic PC

Recruiting

Ames, Iowa, United States, 50010

Contacts

Principal Investigator:

Jason Allen Cascio

Equity Medical LLC

Recruiting

Bowling Green, Kentucky, United States, 42104

Contacts

Principal Investigator:

David Johnson

Family Allergy And Asthma Rsch Inst

Recruiting

Louisville, Kentucky, United States, 40215

Contacts

Principal Investigator:

James Wesley Sublett

Allergy and Asthma Specialist P S C

Recruiting

Owensboro, Kentucky, United States, 42301

Contacts

Principal Investigator:

Lee Clore

Ochsner Health Center

Recruiting

Baton Rouge, Louisiana, United States, 70816

Contacts

Principal Investigator:

Kelser Bourgoyne

Velocity Clinical Research

Recruiting

Lafayette, Louisiana, United States, 70508

Contacts

Principal Investigator:

Jibran Atwi

Johns Hopkins U School of Med

Recruiting

Baltimore, Maryland, United States, 21205

Contacts

Principal Investigator:

Eric Tyrell Oliver

Chesapeake Clinical Research Inc

Recruiting

Baltimore, Maryland, United States, 21236

Contacts

Principal Investigator:

Jonathan Matz

Institute for Asthma and Allergy PC

Recruiting

Chevy Chase, Maryland, United States, 20815

Contacts

Principal Investigator:

Mark Scarupa

Boston Specialists LLC

Recruiting

Boston, Massachusetts, United States, 02111

Contacts

Lina Fikri

lina.f@bfac.org

Principal Investigator:

John Leung

ClinSite Inc

Recruiting

Ann Arbor, Michigan, United States, 48106-0525

Contacts

Principal Investigator:

Rajan Ravikumar

Derm Institute West Michigan PLLC

Recruiting

Caledonia, Michigan, United States, 49316

Contacts

Principal Investigator:

Kristi B Hawley

Henry Ford Hospital

Recruiting

Detroit, Michigan, United States, 48202

Contacts

Principal Investigator:

Alan Baptist

Revival Research Institute

Recruiting

Troy, Michigan, United States, 48084

Contacts

Principal Investigator:

Ali Moiin

Somerset Skin Centre

Recruiting

Troy, Michigan, United States, 48084

Contacts

Principal Investigator:

George Murakawa

Clinical Research Institute

Recruiting

Minneapolis, Minnesota, United States, 55402

Contacts

Principal Investigator:

Hemalini Mehta

University of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

Thomas Pritchard

pritc204@umn.edu

Principal Investigator:

Paul Bigliardi

Mayo Clinic - Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Principal Investigator:

Gerald Volcheck

ENT and Allergy Center of Missouri

Recruiting

Columbia, Missouri, United States, 65201

Contacts

Principal Investigator:

Christine Franzese

The Clinical Research Center

Recruiting

St Louis, Missouri, United States, 63141

Contacts

Principal Investigator:

Jeffrey Tillinghast

Washington University

Recruiting

St Louis, Missouri, United States, 63141

Contacts

Principal Investigator:

Maya Jerath

Somnos Clinical Research

Recruiting

Lincoln, Nebraska, United States, 68510

Contacts

Principal Investigator:

Robert J Szalewski

Allergy and Asthma Center of Las Vegas

Recruiting

Las Vegas, Nevada, United States, 89128

Contacts

Principal Investigator:

Jason Bellak

Las Vegas Dermatology

Recruiting

Las Vegas, Nevada, United States, 89144

Contacts

Principal Investigator:

David Graham Cotter

Hudson Essex Allergy-Circuit Clinical

Recruiting

Belleville, New Jersey, United States, 07109

Contacts

Principal Investigator:

Mark Edward Weinstein

Circuit Clinical Mercer Algy Pulm

Recruiting

Hamilton, New Jersey, United States, 08619

Contacts

Principal Investigator:

Peter Ricketti

Allergy Asthma Assoc Monmouth

Recruiting

Little Silver, New Jersey, United States, 07739

Contacts

Principal Investigator:

Tina Zecca

Allergy Partners of New Jersey PC

Recruiting

Ocean Township, New Jersey, United States, 07712

Contacts

Principal Investigator:

Ellen Sher

Circuit Clinical

Recruiting

Riverdale, New Jersey, United States, 07457

Contacts

Principal Investigator:

Jeffrey Weiss

Equity Medical

Recruiting

The Bronx, New York, United States, 10455

Contacts

Principal Investigator:

Alissa McInerney

Montefiore Medical Center

Recruiting

The Bronx, New York, United States, 10467

Contacts

Principal Investigator:

Golda Hudes

Allergy Partners Of West NC

Recruiting

Asheville, North Carolina, United States, 28801

Contacts

Principal Investigator:

David M Cypcar

UNC DermatologyandSkinCancer Ctr

Recruiting

Chapel Hill, North Carolina, United States, 27516

Contacts

Principal Investigator:

Donna Culton

Bernstein Clinical Research Center

Recruiting

Cincinnati, Ohio, United States, 45231

Contacts

Principal Investigator:

Jonathan Abram Bernstein

CR Services Acquisition US

Recruiting

Columbus, Ohio, United States, 43213

Contacts

Principal Investigator:

Sridhar Guduri

Wright State University

Recruiting

Fairborn, Ohio, United States, 45324

Contacts

Principal Investigator:

Craig Rohan

Toledo Institute of Clinical Research

Recruiting

Toledo, Ohio, United States, 43617

Contacts

Principal Investigator:

Syed Rehman

Unity Clinical Research

Recruiting

Oklahoma City, Oklahoma, United States, 73118

Contacts

Principal Investigator:

Jarad Levin

Vital Prospects Clinical Research Institute

Recruiting

Tulsa, Oklahoma, United States, 74136

Contacts

Principal Investigator:

Iftikhar Hussain

Oregon Medical Research Center

Recruiting

Portland, Oregon, United States, 97223

Contacts

Principal Investigator:

Jason Hawkes

Oregon Health Sciences University

Recruiting

Portland, Oregon, United States, 97239

Contacts

Principal Investigator:

Shyam Joshi

University of Pittsburgh Medical Center

Recruiting

Pittsburgh, Pennsylvania, United States, 15213

Contacts

Principal Investigator:

Merritt Lynn Fajt

Allergy and Clinical Immunology Associates

Recruiting

Pittsburgh, Pennsylvania, United States, 15241

Contacts

Principal Investigator:

Michael Palumbo

Medical Univ Of SC Medical Ctr

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Principal Investigator:

Kelli Williams

Tribe Clinical Research LLC

Recruiting

Greenville, South Carolina, United States, 29601

Contacts

Karleigh Williams

kwilliams@tribecr.com

Principal Investigator:

James Kuhlen

Allergic Disease and Asthma Center

Recruiting

Greenville, South Carolina, United States, 29607

Contacts

Principal Investigator:

Neil L Kao

Charleston ENT and Allergy

Recruiting

North Charleston, South Carolina, United States, 29406

Contacts

Principal Investigator:

Thomas Murphy

National Allergy and Asthma Research LLS

Recruiting

North Charleston, South Carolina, United States, 29420

Contacts

Principal Investigator:

John T Ramey

Goodlettsville Dermatology Research

Recruiting

Goodlettsville, Tennessee, United States, 37072-2301

Contacts

Principal Investigator:

Keith H Loven

International Clinical Research Tennessee LCC

Recruiting

Murfreesboro, Tennessee, United States, 37130

Contacts

Principal Investigator:

Christina Feser

Arlington Center for Dermatology

Recruiting

Arlington, Texas, United States, 76011

Contacts

Principal Investigator:

Angela Moore

Orion Clinical Research

Recruiting

Austin, Texas, United States, 78759

Contacts

Principal Investigator:

William Howland III

Bellaire Dermatology Associates

Recruiting

Bellaire, Texas, United States, 77401

Contacts

Principal Investigator:

Craig F Teller

Reveal Research Institute

Recruiting

Dallas, Texas, United States, 75230

Contacts

Principal Investigator:

Aaron Farberg

Pharma Research and Amp Consult

Recruiting

Dallas, Texas, United States, 75231

Contacts

Principal Investigator:

Gary Gross

Western Sky Medical Research

Recruiting

El Paso, Texas, United States, 79924

Contacts

Principal Investigator:

Todd Funkhouser

Center for Clinical Studies

Recruiting

Houston, Texas, United States, 77030

Contacts

Principal Investigator:

Stephen K Tyring

Sante Clinical Research

Recruiting

Kerrville, Texas, United States, 78028

Contacts

Principal Investigator:

Dale E Mohar

RFSA Dermatology

Recruiting

San Antonio, Texas, United States, 78213

Contacts

Principal Investigator:

Lindsey Finklea

Andante Research

Recruiting

San Antonio, Texas, United States, 78229

Contacts

Principal Investigator:

Robert Ramirez

University Of Utah

Recruiting

Murray, Utah, United States, 84107

Contacts

Principal Investigator:

Christopher Hull

Allergy Associates of Utah

Recruiting

Sandy City, Utah, United States, 84093

Contacts

Principal Investigator:

Andrew M Smith

Forefront Dermatology

Recruiting

Vienna, Virginia, United States, 22182

Contacts

Principal Investigator:

Naiem Issa

Bellingham Asthma Allergy and Immunology

Recruiting

Bellingham, Washington, United States, 98225

Contacts

Principal Investigator:

David Elkayam

More Information

Sponsor

Novartis Pharmaceuticals

Last update posted

Aug 19, 2026

Last verified

Aug, 2026

Keywords

  • BTK inhibitor
  • chronic spontaneous urticaria
  • Urticaria activity score
  • Hives severity score
  • Itch severity score

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Novartis Pharmaceuticals on 2026-08-19.