Recruiting

TMS

Sponsor:

University of South Carolina

Code:

NCT06870552

Conditions

Lexical Access in Neurotypicals

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Interventions

Single-pulse TMS

Study Details

Brief summary:

This study examines the time course of activation of the left anterior temporal lobe (ATL) during lexical processing using Transcranial Magnetic Stimulation (TMS).

Conditions

Lexical Access in Neurotypicals

Study ID

NCT06870552

Start date

Apr 23, 2024

Status verified date

Mar, 2025

Completion date

Sep, 2025

Anticipated

Primary completion date

Aug, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Participants must be within the ages of 18 to 40
  • Native speakers of English

Exclusion Criteria:

  • Potential participants with a clinically reported history of dementia, alcohol abuse, psychiatric or neurological disorders, traumatic brain injury, or extensive vision or hearing problems that prevents them from performing the tasks
  • Contraindication to TMS, determined by a standard TMS screening form
  • Contraindication to MRI, determined by a standard MRI screening form
  • Left handed participants

Study Design

Enrollment

36 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: TMS

Interventions

Single-pulse TMS

A single pulse TMS is delivered at different time points when processing words or numbers.

Primary outcome measure

  • Mean reaction time changes in lexical decision from TMS at 150 ms [ Time Frame: Through study completion, an average of 1 year. ]

Central Contacts and Locations

Central contacts

Rutvik H Desai, PhD

8032617149rutvik@sc.edu

Locations

Prisma Health Richland

Recruiting

Columbia, South Carolina, United States, 29208

Contacts

Rutvik H Desai, PhD

803-261-7149rutvik@sc.edu

Principal Investigator:

Rutvik H Desai, PhD

More Information

Sponsor

University of South Carolina

Last update posted

Mar 11, 2025

Last verified

Mar, 2025

Keywords

  • semantic processing
  • time course
  • lexical access
  • anterior temporal lobe

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of South Carolina on 2025-03-11.