Recruiting

AMP-C

Sponsor:

Massachusetts General Hospital

Code:

NCT06878859

Conditions

Depression - Major Depressive Disorder

Cannabis Use Disorder

Mental Disorder

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Amplification of Positivity - Cannabis Use (AMP-C)

Study Details

Brief summary:

The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outcomes will include changes in depressive symptoms and cannabis use, as well as usability ratings.

Conditions

Depression - Major Depressive Disorder

Cannabis Use Disorder

Mental Disorder

Study ID

NCT06878859

Start date

Feb 23, 2026

Status verified date

May, 2026

Completion date

Jun 29, 2029

Anticipated

Primary completion date

Jan 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Aged ≥ 18 years
  • Resides in the United States
  • Able to read and understand English and willing to provide informed consent/comply with the study protocol
  • Moderate depressive symptom severity, as indicated by the Patient Health Questionnaire-9 (PHQ-9)
  • Problematic cannabis use, as indicated by the Cannabis Use Disorder Identification Test - Revised (CUDIT-R)
  • Current elevated anhedonia, as indicated by the PHQ-9
  • Interest in receiving treatment for their cannabis use and depression
  • Meet criteria for current MDD and CUD per the DSM-5

Exclusion Criteria:

  • History of a psychotic disorder or bipolar disorder type I/II
  • Active suicidal ideation or intent based on the Columbia-Suicide Severity Rating Scale
  • Current psychotherapy engagement
  • Changes in psychotropic medication within six weeks of the start of study

Study Design

Enrollment

80 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Amplification of Positivity - Cannabis Use (AMP-C)

no intervention: Symptom Tracking

Interventions

Amplification of Positivity - Cannabis Use (AMP-C)

AMP-C is a smartphone-based digital intervention that includes activities that focus on positivity (e.g., noticing and capitalizing on positive events) to increase positive emotions, thoughts, and behaviors. The role and impact of CU on the maintenance of depression and reward dysfunction (and vice versa), is intertwined throughout the intervention.

Primary outcome measure

  • Change in Depressive Symptoms (Patient Health Questionnaire-9; PHQ-9) [ Time Frame: Baseline, Primary Endpoint: Post-Intervention (approximately one week after completing intervention), Secondary Endpoints: Intervention Midpoint (4 weeks into intervention), 1-, 3-, 6-, and 12-months after completing intervention ]
  • Change in Cannabis Use Frequency (Daily Sessions, Frequency, Age of Onset, and Quantity of Cannabis Use Inventory; DFAQ-CU) [ Time Frame: Baseline, Primary Endpoint: Post-Intervention (approximately one week after completing intervention), Secondary Endpoints: Intervention Midpoint (4 weeks into intervention), 1-, 3-, 6-, and 12-months after completing intervention ]
  • Usability (System Usability Scale; SUS) [ Time Frame: Post-Intervention (approximately one week after completing intervention) ]

Central Contacts and Locations

Locations

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Shirley Wu, BS

617-724-3532swu24@mgh.harvard.edu

Principal Investigator:

Amanda C Collins, PhD

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Jun 2, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2026-06-02.