Recruiting

Exercise

Sponsor:

University of South Carolina

Code:

NCT06880653

Conditions

Arthritis

Rheumatoid Arthritis (RA)

Gout

Fibromyalgia (FM)

Osteoarthritis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

DREAM Adaptive Intervention

Study Details

Brief summary:

The purpose of the study is to see examine the effects of 3 different levels of physical activity (45 minutes/week, 90 minutes/week, or 150 minutes/week) on arthritis symptoms.

Conditions

Arthritis

Rheumatoid Arthritis (RA)

Gout

Fibromyalgia (FM)

Osteoarthritis

Study ID

NCT06880653

Start date

Mar 28, 2025

Status verified date

Apr, 2026

Completion date

Apr 30, 2029

Anticipated

Primary completion date

Oct 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 18 years or older
  • Have a doctor diagnosed form of arthritis, rheumatoid arthritis, gout, lupus, or fibromyalgia
  • Ability to read and write in English

Exclusion Criteria:

  • Have any contraindications to exercise (besides arthritis)
  • Engage in >45 min/week of Actigraph assessed moderate to vigorous intensity activity
  • Are pregnant, breastfeeding, or planning to become pregnant in the next year
  • Are planning to relocate out of the Columbia, SC area in the next 12 months,
  • Do not have a device compatible with Fitbit
  • Have uncontrolled hypertension (e.g., systolic blood pressure > 160 mmHg or diastolic blood pressure > 100 mmHg)
  • Plan to have a surgery that affects mobility in the next 12 months
  • Have a serious cognitive impairment.
  • Not willing to be randomized to any of the 3 conditions, do not believe they could adhere to the goals, or do not believe they could achieve the highest dose of activity (150 minutes/week).

Study Design

Enrollment

285 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: 45 minutes/week

Participants will be given a goal of 45 minutes/week of moderate-to-vigorous intensity physical activity

experimental: 90 minutes/week

Participants will be given a goal of 90 minutes/week of moderate-to-vigorous intensity physical activity

experimental: 150 minutes/week

Participants will be given a goal of 150 minutes/week of moderate-to-vigorous intensity physical activity

Interventions

DREAM Adaptive Intervention

6-month physical activity program (Dose Response of Exercise for Arthritis Management (DREAM)) which includes monthly phone coaching, Walk With Ease Guidebook, behavioral lessons, and a Fitbit. Participants may receive additional contact (email, text, or phone) if they struggle to meet activity goal.

Primary outcome measure

  • Physical function (6 Minute Walk Test) [ Time Frame: Baseline to 6 months ]

Central Contacts and Locations

Central contacts

Ellen Wingard

803-777-1889EWINGARD@mailbox.sc.edu

Locations

University of South Carolina

Recruiting

Columbia, South Carolina, United States, 29208

Contacts

Christine Pellegrini

803-777-0911pellegca@mailbox.sc.edu

More Information

Sponsor

University of South Carolina

Last update posted

Apr 3, 2026

Last verified

Apr, 2026

Keywords

  • arthritis
  • exercise
  • physical activity

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-24. This information was provided to ClinicalTrials.gov by University of South Carolina on 2026-04-03. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.