Sponsor:
Revolution Medicines, Inc.
Code:
NCT06881784
Conditions
NSCLC (Non-small Cell Lung Cancer)
Non-Small Cell Lung Cancer
NSCLC
NSCLC (Non-small Cell Lung Carcinoma)
NSCLC (Advanced Non-small Cell Lung Cancer)
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Interventions
daraxonrasib
docetaxel
Brief summary:
Conditions
NSCLC (Non-small Cell Lung Cancer)
Non-Small Cell Lung Cancer
NSCLC
NSCLC (Non-small Cell Lung Carcinoma)
NSCLC (Advanced Non-small Cell Lung Cancer)
Study ID
NCT06881784
Start date
May 6, 2025
Status verified date
Jul, 2026
Completion date
Dec 1, 2030
Anticipated
Primary completion date
Dec 1, 2027
Anticipated
Eligibility Criteria
Sex: All
Age: 18+
Healthy Volunteers: Not accepted
Enrollment
590 participants
Anticipated
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary purpose
Treatment
Arms
experimental: daraxonrasib
active comparator: docetaxel
Interventions
daraxonrasib
docetaxel
Primary outcome measure
Central contacts
Locations
Alabama Oncology
Recruiting
Birmingham, Alabama, United States, 35243
Contacts
MemorialCare Long Beach Medical Center
Recruiting
Long Beach, California, United States, 90806
Contacts
Yale University, Smillow Cancer Center
Recruiting
New Haven, Connecticut, United States, 06519
Contacts
Florida Cancer Specialists & Research Institute - South
Recruiting
Fort Myers, Florida, United States, 33901
Contacts
BRCR Global
Recruiting
Plantation, Florida, United States, 33322
Contacts
Cancer Care Centers of Breevard
Recruiting
Rockledge, Florida, United States, 32955
Contacts
Florida Cancer Specialists & Research Institute - North
Recruiting
St. Petersburg, Florida, United States, 33705
Contacts
Cleveland Clinic Martin North
Recruiting
Stuart, Florida, United States, 34994
Contacts
Florida Cancer Specialists & Research Institute - East
Recruiting
West Palm Beach, Florida, United States, 33401
Contacts
University Cancer and Blood Center
Recruiting
Athens, Georgia, United States, 30607
Contacts
Piedmont Healthcare, Inc
Recruiting
Atlanta, Georgia, United States, 30318
Contacts
Winship Cancer Institute
Recruiting
Atlanta, Georgia, United States, 30322
Contacts
University of Illinois Cancer Center
Recruiting
Chicago, Illinois, United States, 60612
Contacts
Center for Care and Discovery
Recruiting
Chicago, Illinois, United States, 60637
Contacts
University of Iowa Health Care Cancer Services Quad Cities
Recruiting
Bettendorf, Iowa, United States, 52722
Contacts
University of Iowa Hospitals & Clinics
Recruiting
Iowa City, Iowa, United States, 52242
Contacts
University of Iowa Health Care, Mission Cancer + Blood
Recruiting
Waukee, Iowa, United States, 50263
Contacts
The University of Kansas Cancer Center
Recruiting
Westwood, Kansas, United States, 66205
Contacts
Johns Hopkins University of Medicine
Recruiting
Baltimore, Maryland, United States, 21224
Contacts
Tiffany Loftus
ThoracicCancerTrials@jhmi.eduTrinity Health Ann Arbor Hospital
Recruiting
Ann Arbor, Michigan, United States, 48106
Contacts
Karmanos Cancer Institute
Recruiting
Detroit, Michigan, United States, 48201
Contacts
Henry Ford Health
Recruiting
Detroit, Michigan, United States, 48202
Contacts
Washington University School of Medicine - Siteman Cancer Center
Recruiting
St Louis, Missouri, United States, 63110
Contacts
St. Vincent Frontier Cancer Center
Recruiting
Billings, Montana, United States, 59102
Contacts
Dartmouth-Hitchcock Medical Center
Recruiting
Lebanon, New Hampshire, United States, 03756
Contacts
John Theurer Cancer Center at Hackensack UMC
Recruiting
Hackensack, New Jersey, United States, 07601
Contacts
Morristown Medical Center (MMCORC)
Recruiting
Morristown, New Jersey, United States, 07960
Contacts
Mary Phiakhamta
maimanivanh.phiakhamta@atlantichealth.orgRoswell Park Cancer Institute
Recruiting
Buffalo, New York, United States, 14263
Contacts
Memorial Sloan Kettering Cancer Center
Recruiting
New York, New York, United States, 10065
Contacts
Montefiore Medical Center
Recruiting
The Bronx, New York, United States, 10461
Contacts
UNC Lineberger Comprehensive Cancer Center at University of North Carolina
Recruiting
Chapel Hill, North Carolina, United States, 27599
Contacts
TriHealth Cancer & Blood Institute Research
Recruiting
Cincinnati, Ohio, United States, 45220
Contacts
Taylor Cancer Research Center
Recruiting
Maumee, Ohio, United States, 43537
Contacts
Oncology Associates of Oregon PC
Recruiting
Eugene, Oregon, United States, 97401
Contacts
Penn State Milton S. Hershey Medical Center
Recruiting
Hershey, Pennsylvania, United States, 17033
Contacts
Avera Saint Luke's Hospital
Recruiting
Aberdeen, South Dakota, United States, 57401
Contacts
Avera Cancer Institute
Recruiting
Sioux Falls, South Dakota, United States, 57105
Contacts
SCRI Oncology Partners - Tennessee
Recruiting
Nashville, Tennessee, United States, 37203
Contacts
Texas Oncology - South Austin
Recruiting
Austin, Texas, United States, 78745
Contacts
Texas Oncology Dallas
Recruiting
Dallas, Texas, United States, 75251
Contacts
MD Anderson Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contacts
Texas Oncology - Gulf Coast
Recruiting
The Woodlands, Texas, United States, 77380
Contacts
Utah Cancer Specialists
Recruiting
Salt Lake City, Utah, United States, 84106
Contacts
Huntsman Cancer Institute
Recruiting
Salt Lake City, Utah, United States, 84112
Contacts
Virginia Cancer Specialists
Recruiting
Fairfax, Virginia, United States, 22031
Contacts
Sponsor
Revolution Medicines, Inc.
Last update posted
Sep 29, 2026
Last verified
Jul, 2026
Keywords
Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-04. This information was provided to ClinicalTrials.gov by Revolution Medicines, Inc. on 2026-09-29. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.