Recruiting

Diet & Exercise

Sponsor:

Ohio State University

Code:

NCT06882460

Conditions

Spinal Cord Injuries

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

Low glycemic load

Electrical stimulation exercise

High glycemic load diet

Study Details

Brief summary:

The purpose of this study is to determine if a low glycemic diet and lower-body electrical stimulation can reduce postprandial hypotension in individuals with chronic spinal cord injury.

Conditions

Spinal Cord Injuries

Study ID

NCT06882460

Start date

May 15, 2025

Status verified date

Apr, 2026

Completion date

Dec 1, 2026

Anticipated

Primary completion date

Dec 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Spinal cord injury (SCI) between C4 and T12 who require use of wheelchair for daily mobility
  • AIS A or B
  • >1-year post-injury

Exclusion Criteria:

  • Currently pregnant of breast-feeding
  • Type 1 or 2 diabetes
  • Previous gut augmentation bariatric surgery
  • Neurological impairment other than SCI
  • History of uncontrolled autonomic dysreflexia
  • History of bone fractures
  • Use of abdominal binder or anti-hypotensive drugs
  • Fitted with pacemaker or defibrillator
  • Currently receiving electrical stimulation training or in the previous year

Study Design

Enrollment

13 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

placebo comparator: High glycemic load

experimental: Low glycemic load

experimental: Electrical Stimulation

Interventions

Low glycemic load

Low glycemic load diet

Electrical stimulation exercise

Lower-body electrical stimulation exercise for 1-h after eating

High glycemic load diet

High glycemic load diet

Primary outcome measure

  • Magnitude of systolic blood pressure decrease (in-lab) [ Time Frame: Visit 2-4, Day 1 ]

Central Contacts and Locations

Central contacts

Matthew Farrow, PhD

614-293-2812Matthew.Farrow@osumc.edu

Ceren Yarar-Fisher, PhD

Ceren.Yarar-Fisher@osumc.edu

Locations

Dodd Rehabilitation Hospital

Recruiting

Columbus, Ohio, United States, 43210

Contacts

Matthew Farrow

Matthew.Farrow@osumc.edu

More Information

Sponsor

Ohio State University

Last update posted

Apr 27, 2026

Last verified

Apr, 2026

Keywords

  • postprandial hypotension
  • electrical stimulation
  • low-glycemic diet

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Ohio State University on 2026-04-27.