Recruiting

Transcranial Direct Current Stimulation

Sponsor:

Sanford Health

Code:

NCT06883266

Conditions

Parkinsons Disease (PD)

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

transcranial direct current stimulation (tDCS)

Sham (No Treatment)

Study Details

Brief summary:

The investigators hypothesize that multi-session anodal tDCS (atDCS) of the left primary motor cortex (M1) will induce long-lasting effects in improving motor function and reducing motor fatigue and fatigability in PD patients.

Conditions

Parkinsons Disease (PD)

Study ID

NCT06883266

Start date

Nov 11, 2024

Status verified date

Jan, 2026

Completion date

Dec 11, 2026

Anticipated

Primary completion date

Nov 11, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Clinical diagnosis of PD with at least two of the four diagnostic criteria for PD (tremor, rigidity, bradykinesia, and postural instability)
  • Must be able to consent

Exclusion Criteria:

  • Patients with dementia (MOCA < 21)
  • PD treatment using deep brain stimulation (DBS)
  • Diagnosis of psychosis
  • Diagnosis of multiple sclerosis
  • Diagnosis of stroke
  • Diagnosis of chronic obstructive pulmonary disease (COPD)
  • Diagnosis of congestive heart failure (CHF)

Study Design

Enrollment

64 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Experimental Group

The experimental group will receive 2mA of anodal transcranial direct current stimulation (tDCS) for 20 minutes daily for 5 consecutive days.

sham comparator: Sham Group

The sham group will be connected to the anodal transcranial direct current stimulation device daily for 5 days. During the 20 minute sessions, the participant will only receive stimulation for a 30-second ramp up period, at which point the stimulation will be discontinued for the remainder of the time.

Interventions

transcranial direct current stimulation (tDCS)

2 mA will be administered for 5 consecutive days for a duration of 20 minutes with electrode placement at the left dorsolateral prefrontal cortex.

Sham (No Treatment)

For 30 seconds, the patient will experience a ramp up of the stimulation, after which point no stimulation will be transmitted for the remainder of the session. This will be administered for 5 consecutive days for a duration of 20 minutes with electrode placement at the left dorsolateral prefrontal cortex

Primary outcome measure

  • Finger and Toe-Tapping on KinesiaOne Device [ Time Frame: 30 minutes; pre-test during the second research visit, post-test on 6th research visit after 5 consecutive days of tDCS, a follow up test on the 7th research visit, 7 days after last tDCS session and 8th visit 14 days after last tDCS session ]

Central Contacts and Locations

Central contacts

Jessica Keller, B.S.

701-417-5781jessica.keller@sanfordhealth.org

Locations

Sanford Brain and Spine Center

Recruiting

Fargo, North Dakota, United States, 58103

Contacts

Jessica Keller, B.S.

701-417-5781jessica.keller@sanfordhealth.org

Principal Investigator:

Jau-Shin Lou, MD

More Information

Sponsor

Sanford Health

Last update posted

Feb 3, 2026

Last verified

Jan, 2026

Keywords

  • Parkinsons Disease
  • tDCS
  • Motor Function
  • Motor Fatigue

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Sanford Health on 2026-02-03.