Recruiting

Observational StudyJUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction

Sponsor:

Hospital for Special Surgery, New York

Code:

NCT06883396

Conditions

Patellar Dislocation, Recurrent

Patellar Dislocation

Patellar Instability

Patellofemoral Dislocation

Patellofemoral Joint Dislocation

Eligibility Criteria

Sex: All

Age: 10 - 35

Healthy Volunteers: Not accepted

Interventions

Medial Patellofemoral Ligament (MPFL) Reconstruction

Study Details

Brief summary:

The goal of this observational study is to learn about the outcomes of medial patellofemoral ligament (MPFL) reconstruction for the treatment of recurrent patellar instability. The main questions it aims to answer are:

What are the risk factors for recurrent patellar instability after MPFL reconstruction?
What functional outcomes do patients report after MPFL reconstruction?

Participants undergoing MPFL reconstruction will answer survey questions about their knee and activity level 1 year and 2 years after surgery.

Conditions

Patellar Dislocation, Recurrent

Patellar Dislocation

Patellar Instability

Patellofemoral Dislocation

Patellofemoral Joint Dislocation

Study ID

NCT06883396

Start date

Jan 1, 2023

Status verified date

Jan, 2026

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Sex: All

Age: 10 - 35

Healthy Volunteers: Not accepted

Inclusion Criteria:

10-35 years old
Recurrent patellar instability with at least one episode defined as either (1) a dislocated patella requiring reduction in the emergency department or (2) a convincing history for dislocation, associated with full giving way, and the following physical findings: (a) hemarthrosis or effusion, (b) tenderness along the medial retinaculum, and (c) apprehension when laterally directed force was applied to the patella or (3) MRI-documented dislocation with associated bone bruises

Exclusion Criteria:

Previous ipsilateral knee surgery
Obligatory/fixed/habitual patella dislocation or subluxation
Unloadable inferior or lateral chondral damage on the patella that would require a tibial tubercle transfer for unloading purposes
Pathologic tibiofemoral instability

Study Design

Enrollment

850 participants

Anticipated

Interventions and Outcome Measures

Arms

Isolated MPFL Reconstruction

Patients with recurrent patellar instability (2 or more dislocation and/or subluxation events) undergoing isolated MPFL reconstruction

Interventions

Medial Patellofemoral Ligament (MPFL) Reconstruction

For the purposes of this study, isolated MPFL reconstruction is defined as MPFL reconstruction with a tendon graft, with or without additional soft tissue procedure(s) including lateral retinacular lengthening or release, patellofemoral chondroplasty and/or cartilage restoration. No patient in the study will receive a bony realignment procedure to treat patellar instability.

Primary outcome measure

Recurrent patellar instability [ Time Frame: Within 24 months post-operatively ]

Central Contacts and Locations

Central contacts

Simone Gruber

646-797-8947 grubers@hss.edu

Natalie Pahapill

646-714-6738 pahapilln@hss.edu

Locations

Stanford University

Recruiting

Redwood City, California, United States, 94063

Contacts

Monica Sri Vel

msvel@stanford.edu

University of Florida

Recruiting

Gainesville, Florida, United States, 32607

Contacts

Tyler LaMonica

lamontj@ortho.ufl.edu

Midwest Orthopaedics at Rush

Recruiting

Chicago, Illinois, United States, 60612

Contacts

cartilage.restoration@rushortho.com

University of Iowa

Recruiting

Iowa City, Iowa, United States, 52242

Contacts

Shannon Ortiz

shannon-ortiz@uiowa.edu

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Serafina Zotter

szotter@mgh.harvard.edu

Boston Children's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Emma Gossman

Emma.Gossman@childrens.harvard.edu

Michael Quinn

Michael.Quinn@childrens.harvard.edu

NYU Langone Health

Recruiting

New York, New York, United States, 10016

Contacts

Ivanka Bhambhani

Ivanka.Bhambhani@nyulangone.org

Hospital for Special Surgery

Recruiting

New York, New York, United States, 10021

Contacts

Simone Gruber

646-797-8947 grubers@hss.edu

Natalie Pahapill

646-714-6738 pahapilln@hss.edu

Principal Investigator:

Beth Shubin Stein, MD

Duke Health

Recruiting

Wake Forest, North Carolina, United States, 27587

Contacts

Courtney Pyles

courtney.pyles@duke.edu

Cassandra Rhodes

cassandra.rhodes@duke.edu

Cincinnati Children's Hospital Medical Center

Recruiting

Cincinnati, Ohio, United States, 45229

Contacts

Matthew Veerkamp

513-636-3775 Matthew.Veerkamp@cchmc.org

Principal Investigator:

Shital Parikh, MD

Ohio State University Wexler Medical Center

Recruiting

Dublin, Ohio, United States, 43016

Contacts

Michael Keller

Michael.Keller@osumc.edu

Oregon Health & Science University

Recruiting

Portland, Oregon, United States, 97239

Contacts

Albert Yim

yima@ohsu.edu

Scottish Rite for Children

Recruiting

Dallas, Texas, United States, 75219

Contacts

Bayley Selee

Bayley.Selee@tsrh.org

Antonia Dinulescu

antonia.dinulescu@tsrh.org

More Information

Sponsor

Hospital for Special Surgery, New York

Last update posted

Feb 13, 2026

Last verified

Jan, 2026

Keywords

Patella
Patella Dislocation
Patellar Instability
Recurrent Patellar Instability
MPFL
Medial Patellofemoral Ligament
Medial Patellofemoral Ligament Reconstruction
Patellofemoral Instability

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Hospital for Special Surgery, New York on 2026-02-13.