Recruiting

Observational Study

Sponsor:

Mayo Clinic

Code:

NCT06891534

Conditions

Obesity, Abdominal

Feeding Patterns

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Interventions

Continuous Feeding

Intermittent feeding

Study Details

Brief summary:

The goal of this study is to understand the underlying circadian rhythms in subcutaneous adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesity.

Conditions

Obesity, Abdominal

Feeding Patterns

Study ID

NCT06891534

Start date

Jul 1, 2021

Status verified date

Apr, 2026

Completion date

Dec, 2030

Anticipated

Primary completion date

Dec, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Inclusion Criteria:

  • BMI 20-25 kg/m2 or 30-37 kg/m2
  • For participants with obesity a waist-to-hip ratio of ≥0.95 in males and ≥0.90 in females.
  • sedentary
  • females: non pregnant or breastfeeding
  • ability to provide written informed consent and follow study instructions

Exclusion Criteria:

  • History of mediations that impact adipocyte/lipid metabolism
  • smoking
  • insomnia
  • sleep apnea
  • sleep medication use
  • employment in night or shift work
  • extreme chronotypes
  • Allergy to lidocaine

Study Design

Enrollment

40 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

active comparator: Normal weight participants

active comparator: Participants with obesity

Interventions

Continuous Feeding

Participants will receive 24-hour continuous feeds through an NG tube

Intermittent feeding

Participants will receive 3 boluses of feeding per day at regular meal times through an NG tube to mimic normal meals.

Primary outcome measure

  • rhythmicity of circadian clock mRNA in adipose tissue [ Time Frame: 24 hour ]

Central Contacts and Locations

Central contacts

Kelli A Lytle, PhD

507-255-1488lytle.kelli@mayo.edu

Locations

Mayo Clinic

Recruiting

Rochester, Minnesota, United States, 55901

Contacts

Kelli A Lytle, PhD

503-255-1488lytle.kelli@mayo.edu

More Information

Sponsor

Mayo Clinic

Last update posted

Apr 14, 2026

Last verified

Apr, 2026

Keywords

  • circadian rhythms
  • adipose tissue
  • obesity
  • feeding pattern

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-04-14.