Recruiting

Observational Study

Sponsor:

Rush University Medical Center

Code:

NCT06899750

Conditions

Hypertension

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

E3 Multidisciplinary Team

E3 Self-Guided Hypertension Education Program

Study Details

Brief summary:

This study aims to compare a multidisciplinary clinical hypertension and social needs intervention to enhanced standard of care for hypertension management in primary care clinics with regards to hypertension control outcomes.

Conditions

Hypertension

Study ID

NCT06899750

Start date

Feb 10, 2025

Status verified date

Jun, 2026

Completion date

Oct 1, 2026

Anticipated

Primary completion date

Oct 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults 18 years or older
  • African American and/or Latinx
  • Uncontrolled stage 2 hypertension, BP >/= 140/90
  • Patient is following with Rush primary care provider in eligible Rush primary care clinics
  • Patient has a smart phone (Android or iOS)
  • Patient has an email

Exclusion Criteria:

  • Organ transplant recipient
  • On dialysis
  • Patient is already participating in another remote hypertension monitoring program
  • Patient is not interested in participating in the program
  • Patient has already participated in the E3 Hypertension program or the E3 Diabetes program

Study Design

Enrollment

200 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Hypertension Team Based Group

A multidisciplinary team composed of a pharmacist, social worker, and nurse coupled to a self-monitoring blood pressure phone app will provide hypertension monitoring, medication titration, diet and lifestyle education, and referrals for social needs. The team will interact with the patients predominantly via tele-health remotely for 6 months.

active comparator: Hypertension Self-Guided Group

A research assistant ensures patients in the self-guided group have a home blood pressure monitor on enrollment and will call patients at 3 and 6 months to ensure the blood pressure monitor is functioning correctly and to remind patients to check their blood pressure and follow-up with their primary care doctors. Patients will continue with standard clinical care for hypertension in addition to receiving timed, mailed educational materials on hypertension, remote monitoring, diet and lifestyle recommendations for 6 months.

Interventions

E3 Multidisciplinary Team

The E3 Multidisciplinary team is composed of a remote pharmacist, social worker, and nurse working together with patients via a remote monitoring, educational hypertension phone app to overcome barriers to hypertension control via behavioral change, medication adherence and titration, diet and lifestyle education and resource referrals for social needs.

E3 Self-Guided Hypertension Education Program

Patients will receive timed, mailed educational materials on hypertension self-monitoring, diet and lifestyle modifications to supplement usual clinic-based hypertension care with their primary care doctor. A research assistant will ensure patients have home blood pressure monitors on enrollment, and will remind patients to check their blood pressures and follow-up with their primary care doctors at 3 months and 6 months.

Primary outcome measure

  • Systolic blood pressure change at 6 months [ Time Frame: 6 months ]

Central Contacts and Locations

Central contacts

Kristen Pallok, MD

13129426700Kristen_N_Pallok@rush.edu

Elizabeth Legorreta, MSN, NP-C

3129426700Elizabeth_M_Legorreta@rush.edu

Locations

Rush University Medical Center

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Kristen Pallok, MD

312-942-6700Kristen_N_Pallok@rush.edu

Elizabeth Legorreta, MSN, NP-C

3129426700Elizabeth_M_Legorreta@rush.edu

Principal Investigator:

Kristen Pallok, MD

More Information

Sponsor

Rush University Medical Center

Last update posted

Jun 18, 2026

Last verified

Jun, 2026

Keywords

  • hypertension
  • self-monitoring
  • social determinants of health
  • adherence

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Rush University Medical Center on 2026-06-18.