Recruiting

WPPC vs. EggsDairy Choline Bioavailability

Sponsor:

University of Wisconsin, Madison

Code:

NCT06902480

Conditions

Post-menopausal Women

Post-menopausal Status

Eligibility Criteria

Sex: Female

Age: 51 - 70

Healthy Volunteers: Accepted

Interventions

WPPC

Whole egg powder

Study Details

Brief summary:

The goal of this clinical trial is to find out if dairy is a good source of choline compared to eggs. The main questions it aims to answer are:

How the body uses choline; and,
What effect WPPC has on choline metabolism.

Researchers will compare Whey Protein Phospholipid Concentrate (WPPC) to whole egg powder to see if WPPC is as effective as eggs.

Participants will drink a chocolate-flavored smoothie mixed with either WPPC or whole egg powder.

Conditions

Post-menopausal Women

Post-menopausal Status

Study ID

NCT06902480

Start date

Sep 18, 2026

Status verified date

Aug, 2026

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Sex: Female

Age: 51 - 70

Healthy Volunteers: Accepted

Inclusion Criteria:

Ages between 51 and 70
Is currently post-menopausal (Post-menopausal is a term used to describe the time in a woman's life after she has gone through menopause. This usually happens between the ages of 45 and 55. Menopause is when a woman's menstrual periods stop permanently (at least 12 months))
Not allergic to the intervention foods and allergens that are related to the production of intervention foods (e.g. dairy products, egg, fish, peanut, shellfish, soy, tree nuts, wheat, crustaceans, gluten, mollusks, mustard, sesame seeds.)
Had stable body weight (± 5%) for the past 6 months
Free from cancer
Did not have weight loss surgery, colon surgery
Do not have chronic kidney diseases
Do not have malabsorption towards fat and dairy products
Willing to complete health surveys
Willing to complete two 4-day food diaries
Willing to consume the intervention smoothies
Willing to provide blood, urine, fecal samples at baseline and after 10 days of intervention

Exclusion Criteria:

On weight loss/weight gain diets
Diagnosed with fat malabsorption
Undergoing weight loss surgery
Diagnosed with chronic kidney diseases
Allergic to the intervention foods and allergens that are related to the production of intervention foods (e.g. dairy products, egg, chocolate, fish, peanut, shellfish, soy, tree nuts, wheat, crustaceans, gluten, mollusks, mustard, sesame seeds, banana, strawberry, raspberry, blackberry, blueberry.)
Regularly using antibiotics or probiotics or prebiotics
Regularly using weight-loss drugs (GLP-1, Orlistat, Cetilistat, etc.)
Regularly using laxatives
Unable to avoid strenuous exercise during the study (>4 h vigorous exercise per day)

Study Design

Enrollment

24 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Whey Protein Phospholipid Concentrate (WPPC)

Participants will drink a chocolate-flavored smoothie with WPPC added

experimental: Pasteurized whole egg powder

Participants will drink a chocolate-flavored smoothie with egg powder added

Interventions

WPPC

A chocolate-flavored smoothie with WPPC added

Whole egg powder

A chocolate-flavored smoothie with whole egg powder added

Primary outcome measure

Change in circulating choline [ Time Frame: Baseline to 10 days ]

Central Contacts and Locations

Central contacts

Kevin Shih

919-338-9453 sshih22@wisc.edu

Locations

University of Wisconsin - Madison

Recruiting

Madison, Wisconsin, United States, 53705

Contacts

Kevin Shih

sshih22@wisc.edu

Principal Investigator:

Bradley Bolling, PhD

More Information

Sponsor

University of Wisconsin, Madison

Last update posted

Sep 29, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-30. This information was provided to ClinicalTrials.gov by University of Wisconsin, Madison on 2026-09-29. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.