Recruiting

Botulinum Toxin

Sponsor:

Boston Medical Center

Code:

NCT06903975

Conditions

Neck Muscle Issue

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Interventions

prabotulinumtoxinA-xvfs

Study Details

Brief summary:

Botulinum toxin injections have been used both in the face and neck for many years. However, injection into the sternocleidomastoid muscle (SCM) has only been done to treat neck spasms. In this study botulinum toxin will be injected into the SCM to determine if this will result in a temporary slimming effect on the neck and produce a more feminine, youthful neck contour.

Conditions

Neck Muscle Issue

Study ID

NCT06903975

Start date

May 14, 2025

Status verified date

Aug, 2026

Completion date

Mar, 2027

Anticipated

Primary completion date

Mar, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age eligible individual seeking a more feminine neck appearance

Exclusion Criteria:

  • Prior neuromodulator injections in the sternocleidomastoid muscles (SCM) within the past year
  • Current anticoagulant use
  • Body mass index (BMI) >30
  • Anticipation of significant weight gain or loss during the study period (e.g. patients taking or planning to take within the study period a semaglutide medication.)
  • Prior allergy to botulinum toxin A
  • Currently pregnant or breastfeeding

Study Design

Enrollment

30 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Botulinum injection into SCM

All participants will receive bilateral botulinum injections into the SCM.

Interventions

prabotulinumtoxinA-xvfs

Each participant will receive 60 units (U) of prabotulinumtoxinA-xvfs into each SCM for a total of 120 U. Participants will return in 2 weeks to determine if any touch-up injection is needed.

Primary outcome measure

  • Neck circumference [ Time Frame: Baseline, 4 weeks ]

Central Contacts and Locations

Central contacts

Jeffrey Spiegel, MD

617 566-3223Jeffrey.Spiegel@bmc.org

Amanda Goslawski, MD

617 638-7934Amanda.Goslawski@bmc.org

Locations

The Spiegel Center

Recruiting

Newton, Massachusetts, United States, 02459

Contacts

Jeffrey Spiegel, MD

drspiegel@drspiegel.com

Amanda Goslawski, MD

Amanda.Goslawski@bmc.org

More Information

Sponsor

Boston Medical Center

Last update posted

Aug 31, 2026

Last verified

Aug, 2026

Keywords

  • Neck circumference
  • Neck aesthetics
  • Sternocleidomastoid muscles (SCM)
  • Botulinum injection
  • PrabotulinumtoxinA-xvfs injection

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Boston Medical Center on 2026-08-31.