Recruiting

ACT on Vaping

Sponsor:

Fred Hutchinson Cancer Center

Code:

NCT06909500

Conditions

Nicotine Dependence

Tobacco-Related Carcinoma

Eligibility Criteria

Sex: All

Age: 18 - 30

Healthy Volunteers: Accepted

Interventions

Smartphone app

Smartphone app

Text Message

Text Message

Survey Administration

Study Details

Brief summary:

This clinical trial evaluates a smartphone application (app) called Acceptance and Commitment Therapy (ACT) on Vaping for helping young adults quit using electronic cigarettes (e-cigarettes). E-cigarettes pose numerous risks, particularly to youth and young adults. Addressing the high prevalence of e-cigarette use by young adults requires effective and accessible treatments to support current users to quit. Research shows this group prefers and benefits from newer methods of treatment delivery such as digital interventions. ACT on Vaping is a digital therapeutic intended to deliver behavioral therapy to young adults who vape to motivate and support abstinence from all nicotine and tobacco products. The app contains sessions that promote awareness of cues that trigger tobacco use and teach skills for responding to these triggers in a way that is tailored for the participant's readiness to quit. Receiving access to the ACT on Vaping app may be effective in helping young adults quit vaping.

Conditions

Nicotine Dependence

Tobacco-Related Carcinoma

Study ID

NCT06909500

Start date

May 20, 2026

Status verified date

Sep, 2026

Completion date

Nov 15, 2027

Anticipated

Primary completion date

Nov 15, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 30

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age 18-30
  • Current weekly user of e-cigarette product(s) for the last 30 days
  • Has a smartphone; either an Android (running version 12 or higher) or iPhone (running iOS version 17 or higher, iPhone 11 or more recent)
  • Experience downloading and using one or more apps on their smartphone
  • Have a mobile data plan and/or access to WiFi to support the use of the ACT on Vaping app
  • Has access to text messaging
  • Has an email address
  • United States (US) resident, with a US mailing address
  • Willing to complete all study procedures
  • Comfortable reading and writing in English

Exclusion Criteria:

  • Currently using other tobacco cessation treatments at the time of screening, including pharmacotherapy or behavioral support (note: use of these treatment is allowable during trial participation)
  • Member of the same household as another research participant
  • Currently in prison
  • Google voice number as sole phone number, due to its association with fraudulent study entry attempts
  • Is ineligible per fraud prevention protocol
  • Employees/family of investigator or study center

Study Design

Enrollment

1178 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Arm I (ACT on Vaping app (Version A) + incentivized texts + intervention texts)

Participants receive access to the ACT on Vaping app utilizing Acceptance and Commitment Therapy. Participants also receive text message intervention content, as well as incentivized text message check-ins at 2 weeks, 2 months, and 4 months to assess changes in vaping on study.

sham comparator: Arm II (ACT on Vaping app (Version B) + incentivized texts)

Participants receive access to the ACT on Vaping app including health education content. Participants receive incentivized text message check-ins at 2 weeks, 2 months, and 4 months to assess changes in vaping on study.

Interventions

Smartphone app

Receive access to the ACT on Vaping app

Smartphone app

Receive access to the ACT on Vaping app

Text Message

Receive incentivized text messages to access vaping status

Text Message

Receive intervention text messages

Survey Administration

Ancillary studies

Primary outcome measure

  • Cotinine-confirmed 30-day point prevalence abstinence from all nicotine and tobacco [ Time Frame: At 6 months post-randomization ]

Central Contacts and Locations

Central contacts

Jaimee Heffner, PhD

206-667-7314jheffner@fredhutch.org

Locations

Fred Hutch/University of Washington Cancer Consortium

Recruiting

Seattle, Washington, United States, 98109

Contacts

Jaimee Heffner, PhD

206-667-7314jheffner@fredhutch.org

Principal Investigator:

Jaimee Heffner, PhD

More Information

Sponsor

Fred Hutchinson Cancer Center

Last update posted

Sep 8, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Fred Hutchinson Cancer Center on 2026-09-08.