Recruiting

Digital Intervention

Sponsor:

UCLA

Code:

NCT06916221

Conditions

Long-Term Memory

Inhibitory Control

Mild Cognitive Impairment

Eligibility Criteria

Sex: All

Age: 60 - 70+

Healthy Volunteers: Not accepted

Interventions

Long Term Memory

Worder

Study Details

Brief summary:

Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM). The decline in these faculties is accelerated and becomes significant deficits in LTM and cognitive control functions at the level or a diagnosis of Mild Cognitive Impairment (MCI). Training with the navigation game, relative to training with control games, is expected to improve LTM performance for older adult participants.

Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function.

Participants will conduct study activities remotely (e.g., at-home):

1. Baseline Assessment. Complete a series of cognitive assessments and surveys.
2. Intervention. Engage in a digital intervention for up to 8 weeks.
3. Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment.
4. Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.

Conditions

Long-Term Memory

Inhibitory Control

Mild Cognitive Impairment

Study ID

NCT06916221

Start date

Aug 20, 2025

Status verified date

Mar, 2026

Completion date

Jul 31, 2028

Anticipated

Primary completion date

Jan 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 60 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Minimum of 12 years of education
  • English fluency: All task instructions are presented in English language text. In order to control for sufficient and equivalent participant comprehension of the procedures and instructions, we require their self-report of fluency in English.
  • Normal or corrected-to-normal vision
  • Normal or corrected-to-normal hearing
  • Medically healthy older adults, including those with below-average cognitive performance /MCI patients without dementia referred by neuropsychologists (i.e., no participant medical records will be reviewed).

Exclusion Criteria:

  • Under the age of 60
  • Clinical diagnosis of neurological or psychiatric disorder Clinical diagnosis of dementia or AD8 score of >4
  • Visually or hearing impaired without correction to normal
  • Regularly (one or more times per week) practicing an instrument within the last year
  • 10 years or more of formal musical instrument training

Study Design

Enrollment

150 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Long Term Memory

Multi-session cognitive intervention as a computer game that presents an adaptive spatial wayfinding challenge.

active comparator: Worder

Multi-session cognitive intervention as a computer game that presents a word puzzle.

Interventions

Long Term Memory

Tablet computer game designed to stimulate environmental enrichment via an adaptive and immersive experience learning virtual neighborhoods and errands in order to complete assigned errands.

Worder

Tablet computer game designed to stimulate interest in solving word puzzles, much like the Boggle game.

Primary outcome measure

  • MDT change in recognition memory [ Time Frame: baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests ]
  • TOUR change in cued recall memory [ Time Frame: baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests ]

Central Contacts and Locations

Central contacts

Melissa Arioli, AB

(415) 502-7321bid.core@ucsf.edu

Locations

University of California, San Francsico

Recruiting

San Francisco, California, United States, 94158

More Information

Sponsor

University of California, San Francisco

Last update posted

Apr 2, 2026

Last verified

Mar, 2026

Keywords

  • cognitive training
  • cognitive aging
  • memory

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-04-02.