Recruiting

Digital Interventions

Sponsor:

UCLA

Code:

NCT06918704

Conditions

Working Memory

Inhibitory Control

Mild Cognitive Impairment (MCI)

Aging

Eligibility Criteria

Sex: All

Age: 60 - 70+

Healthy Volunteers: Accepted

Interventions

Coherence

Worder

Study Details

Brief summary:

The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are:

1. Does engagement in with a digital intervention improve working memory?
2. Does engagement in with a digital intervention improve inhibitory control?

Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function.

Participants will conduct study activities remotely (e.g., at-home):

1. Baseline Assessment. Complete a series of cognitive assessments and surveys.
2. Intervention. Engage in a digital intervention for up to 8 weeks.
3. Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment.
4. Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.

Conditions

Working Memory

Inhibitory Control

Mild Cognitive Impairment (MCI)

Aging

Study ID

NCT06918704

Start date

Aug 15, 2025

Status verified date

Mar, 2026

Completion date

Jul 31, 2028

Anticipated

Primary completion date

Jan 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 60 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Minimum of 12 years of education
  • English fluency
  • Normal or corrected-to-normal vision
  • Normal or corrected-to-normal vision
  • Medically healthy older adults including those with below-average cognitive performance or mild cognitive impairment patients without dementia

Exclusion Criteria:

  • Under the age of 60
  • Clinical diagnosis of neurological or psychiatric disorder
  • Visually or hearing impaired without correction to normal
  • Clinical diagnosis of dementia or AD8 score of >3
  • Regularly (one or more times per week) practicing an instrument within the last year
  • 10 or more years of formal musical instrument training

Study Design

Enrollment

150 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Coherence Intervention

Participants in this arm will engage with the Coherence Intervention.

active comparator: Worder Intervention

Participants in this arm will engage with the Worder intervention.

Interventions

Coherence

Coherence is a music-based rhythm training app.

Worder

Worder is a word search app.

Primary outcome measure

  • Working Memory [ Time Frame: Immediately before the intervention, Immediately after the intervention, 6 months after the intervention ]

Central Contacts and Locations

Central contacts

Melissa Arioli

(415) 506-7321Bid.Core@ucsf.edu

Locations

University of California, San Francisco

Recruiting

San Francisco, California, United States, 94621

More Information

Sponsor

University of California, San Francisco

Last update posted

Apr 1, 2026

Last verified

Mar, 2026

Keywords

  • Cognitive Training
  • Working Memory
  • MCI
  • Inhibitory Control
  • Mild Cognitive Impairment
  • Aging

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-04-01.