Recruiting

Immune Cells & Glucose

Sponsor:

Vanderbilt University Medical Center

Code:

NCT06930976

Conditions

Glucose

Metabolism

Isotope Labeling

Immune System and Related Disorders

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

13C6-Glucose

Study Details

Brief summary:

The purpose of this study is to understand how cells of the immune system use the common sugar glucose to fuel energy production and as a building block within the cell. Investigators will intravenously infuse a non-radioactive glucose tracer into participants over a few hours and collect immune cells from the blood to track uptake and usage of this glucose within these immune cells.

Conditions

Glucose

Metabolism

Isotope Labeling

Immune System and Related Disorders

Study ID

NCT06930976

Start date

Oct 1, 2025

Status verified date

Oct, 2025

Completion date

Jun 30, 2027

Anticipated

Primary completion date

Jun 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adults aged 18 or older

Exclusion Criteria:

  • Pregnant
  • Prisoner or in police custody
  • Uncontrolled hyperglycemia/diabetes
  • Current participation in another study where the total volume of blood drawn, when added to this study blood draw volume, exceeds 500cc in an 8 week period
  • Any medical issue or pharmacologic exposure which, in the opinion of the study investigator, that might interfere with the study objectives
  • Any reason which, in the opinion of the study investigator, adds additional risk to the participant

Study Design

Enrollment

12 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

other: 13C6-Glucose

10-25gm of 13C6-Glucose

Interventions

13C6-Glucose

Compounded as 5% 13C6-Glucose in sterile water given IV over 2-4 hours as a split bolus and infusion

Primary outcome measure

  • 13C6-glucose uptake in immune cells [ Time Frame: Up to 4 hours ]

Central Contacts and Locations

Central contacts

Matthew T Stier, M.D., Ph.D.

615-875-4978matthew.stier@vumc.org

Locations

Vanderbilt University Medical Center

Recruiting

Nashville, Tennessee, United States, 37212

More Information

Sponsor

Vanderbilt University Medical Center

Last update posted

Nov 4, 2025

Last verified

Oct, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Vanderbilt University Medical Center on 2025-11-04.