Recruiting

Observational Study

Sponsor:

Baycrest

Code:

NCT06933667

Conditions

Prevention

Dementia

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

Interventions

Physical Activity

Brain-healthy Eating

Cognitive Engagement

Social Connections

Mental Wellbeing

Study Details

Brief summary:

Participants (n=450; aged 50+; without a diagnosis of dementia; sufficiently fluent in English to complete the assessments and engage in programming) receive a comprehensive dementia risk assessment, including nonmodifiable and modifiable risk factors, from which they receive a Personalized Dementia Risk Report and Program Strategy, indicating their health conditions increasing and their risk level in five modifiable risk domains: physical activity, brain- healthy eating, cognitive engagement, social connections, and mental wellbeing. Equipped with this information, participants enroll in programs within the Centre to address their risk factors. Changes to their dementia risk, cognition, and Personalized Program Strategy are communicated through re-assessments of risk factors every six months (risk and cognition) and every year (comprehensive assessment).

Conditions

Prevention

Dementia

Study ID

NCT06933667

Start date

Mar 26, 2024

Status verified date

Apr, 2025

Completion date

Aug 31, 2027

Anticipated

Primary completion date

Aug 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Aged 50 years or older
  • Sufficiently fluent in English to complete the assessments and participate in programming.

Exclusion Criteria:

  • Diagnosis of dementia.

Study Design

Enrollment

450 participants

Anticipated

Allocation

Non randomized

Intervention Model

Single group

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

active comparator: Physical Activity

Participants are encouraged to work up to the Canadian Guidelines of 150 minutes a week of moderate to vigorous activity and to focus on balance and stretching.

active comparator: Brain-healthy Eating

Participants are recommended to take five required courses about the CCNA Brain Health Food Guide, then take additional courses of their choice.

active comparator: Cognitive Engagement

Participants are encouraged to participate in at least one hour of cognitively engaging programs.

active comparator: Social Connections

All programs, regardless of type, encourage social connections, through ice-breakers, peer mentoring, and time to chat before and after classes.

active comparator: Mental Wellbeing

Participants are encouraged to participate in at least one hour of programming focused on mental wellbeing (e.g., meditation, relaxation).

Interventions

Physical Activity

Participants can chose (with input from a kinesiologist as required) from courses of varying intensity in our gym, warm water pool, or classrooms.

Brain-healthy Eating

Participants take five foundational courses: Brain-healthy eating, Healthy protein choices, Colour your diet: Maximize the benefits of fruits and vegetables; Interpreting nutrition facts labels; and Salt and sugar: How much is too much? They are also encouraged to take additional nutrition programs.

Cognitive Engagement

Participants can sign up for any lecture, discussion group, book club, creative arts program, etc. linked to the Cognitive Engagement risk factor.

Social Connections

Social Connections are baked into all other programming. Our instructors are trained in how to foster connections among participants, through peer coaching, ice-breakers, etc., and are asked to leave some time at the beginning and end of programs for participants to chat. We also hold special social events such as game nights.

Mental Wellbeing

Participants are encouraged to enroll in one a week of relevant programming (e.g., meditation, relaxation).

Primary outcome measure

  • Physical Activity [ Time Frame: Every six months over two years. ]
  • Cognition [ Time Frame: We expect to see this at the two year mark. ]
  • Brain-Healthy Eating [ Time Frame: Every six months over two years. ]
  • Cognitive Engagement [ Time Frame: Every six months over two years. ]
  • Social Connections [ Time Frame: Every six months over two years. ]
  • Mental Wellbeing [ Time Frame: Every six months over two years. ]
  • Diastolic Blood Pressure [ Time Frame: Every year over two years. ]
  • Systolic Blood Pressure [ Time Frame: Every year over two years. ]
  • Percent body fat [ Time Frame: Every year over two years. ]
  • Low density lipoprotein [ Time Frame: Every year over two years. ]
  • C-reactive protein [ Time Frame: Every year over two years. ]
  • Interleukin-6 [ Time Frame: Every year over two years. ]
  • HbA1c [ Time Frame: Every year over two years. ]
  • Cognition [ Time Frame: Every six months over two years. ]

Central Contacts and Locations

Central contacts

Nicole D. Anderson, PhD, CPsych

416-785-2500nanderson@research.baycrest.org

Locations

Baycrest

Recruiting

Toronto, Ontario, Canada, M6A 2E1

More Information

Sponsor

Baycrest

Last update posted

Apr 18, 2025

Last verified

Apr, 2025

Keywords

  • personalized dementia prevention
  • lifestyle factors

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-25. This information was provided to ClinicalTrials.gov by Baycrest on 2025-04-18. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.