Recruiting

Observational Study

Sponsor:

Stanford University

Code:

NCT06935253

Conditions

Hypertrophic Cardiomyopathy (HCM)

Cardiomyopathy

Genetic Disease

Cardiology

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Large Language Model

Study Details

Brief summary:

This study evaluates the impact of large language models (LLMs) versus traditional decision support tools on clinical decision-making in cardiology. General cardiologists will be randomized to manage real patient cases from a cardiovascular genetic cardiomyopathy clinic, with or without AI assistance. Each case will be assessed by two cardiologists, and their responses will be graded by blinded subspecialty experts using a standardized evaluation rubric.

Conditions

Hypertrophic Cardiomyopathy (HCM)

Cardiomyopathy

Genetic Disease

Cardiology

Study ID

NCT06935253

Start date

Jan 10, 2025

Status verified date

May, 2025

Completion date

Dec, 2025

Anticipated

Primary completion date

Nov, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Board certified or board eligible Cardiologist.

Exclusion Criteria:

  • Not currently practicing clinically

Study Design

Enrollment

12 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

active comparator: Large Language Model

This group will be given access to a Large Language Model

no intervention: Usual resources

Group will not be given access to a Large Language Model but will be encouraged to use any resources they usually use in their practice besides large language models (UpToDate, Dynamed etc).

Interventions

Large Language Model

The intervention is a Large Language Model.

Primary outcome measure

  • Subspecialist Preference [ Time Frame: Subspecialist evaluation will occur within 1 month of participant completing their assessment ]

Central Contacts and Locations

Central contacts

Jack W O'Sullivan, MBBS, DPhil

+16507367878jackos@stanford.edu

Euan A Ashley, BSc, MB ChB, DPhil

+16507367878deptmedchair@stanford.edu

Locations

Stanford

Recruiting

Palo Alto, California, United States, 94303

Contacts

Jack W O'Sullivan, MD, PhD

6503009129jackos@stanford.edu

Euan A Ashley, MD, PhD

650-736-7878euan@stanford.edu

Principal Investigator:

Euan A Ashley, MD, PhD

More Information

Sponsor

Stanford University

Last update posted

May 15, 2025

Last verified

May, 2025

Keywords

  • Large language models
  • Cardiology

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Stanford University on 2025-05-15.