Recruiting

Platelet-Rich Fibrinogen

Sponsor:

University of Nebraska

Code:

NCT06943846

Conditions

Edentulism

Eligibility Criteria

Sex: All

Age: 14 - 70+

Healthy Volunteers: Not accepted

Interventions

Platelet-rich fibrin (PRF)

Study Details

Brief summary:

The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.

Conditions

Edentulism

Study ID

NCT06943846

Start date

May 1, 2025

Status verified date

Jan, 2026

Completion date

May, 2027

Anticipated

Primary completion date

May, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 14 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patient at University of Nebraska Medical Center (UNMC) College of Dentistry
  • Requires extraction of posterior tooth
  • Able and willing to provide consent/assent

Exclusion Criteria:

  • Systemic conditions that delay wound healing
  • Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing Smoking and vaping Pregnancy

Study Design

Enrollment

12 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

active comparator: Aged Participants Treated with Platelet-rich Fibrinogen

Participants aged 50 to 80 years of age will receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.

no intervention: Aged Control

Participants aged 50 to 80 years of age will not receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.

active comparator: Young Participants Treated with Platelet-rich Fibrinogen

Participants aged 14 to 18 years of age will receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.

no intervention: Young Control

Participants aged 14 to 18 years of age will not receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.

Interventions

Platelet-rich fibrin (PRF)

Platelet-rich fibrin added to extraction socket

Primary outcome measure

  • Cytokine Concentration [ Time Frame: Baseline and two weeks post-extraction ]

Central Contacts and Locations

Central contacts

Amy C Killeen, DDS, MS

402-472-7848akilleen@unmc.edu

Locations

University of Nebraska Medical Center College of Dentistry

Recruiting

Lincoln, Nebraska, United States, 68358

Contacts

Amy C Killeen, DDS, MS

402-472-7948akilleen@unmc.edu

More Information

Sponsor

University of Nebraska

Last update posted

Jan 27, 2026

Last verified

Jan, 2026

Keywords

  • extraction
  • platelet-rich
  • fibrin
  • healing

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Nebraska on 2026-01-27.