Recruiting

Pumpkin Seed Oil

Sponsor:

Northwestern University

Code:

NCT06944392

Conditions

Overactive Bladder (OAB)

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Pumpkin Seed Extract

Study Details

Brief summary:

This is a pilot study to assess using validated outcome measures how ingesting pumpkin seed oil extract supports patient bladder function in a United States population.

Conditions

Overactive Bladder (OAB)

Study ID

NCT06944392

Start date

Apr 11, 2025

Status verified date

Apr, 2026

Completion date

Oct 1, 2026

Anticipated

Primary completion date

Aug 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • All patients evaluated at Northwestern's IPHP who report bladder function consistent with overactive bladder (urinary urgency, with or without urinary frequency more than 8 times daily or nocturia, with or without urgency urinary incontinence) at their index visit, who are also willing to use a dietary supplement and not initiate additional behavioral, medication or procedural treatment for 12 weeks following pumpkin seed oil extract initiation.

Exclusion Criteria:

  • Patients with any of the following will be excluded from the study:
  • Use of other supplements that contain pumpkin seed oil
  • ≥Stage 3 pelvic organ prolapse
  • Urinary post-void residual ≥150cc
  • Culture-proven urinary tract infection at time of study enrollment
  • Recurrent urinary tract infection
  • Neurogenic bladder
  • Abdominal or pelvic malignancy
  • Initiation of new overactive bladder medications or supplements during study period or in the 3 months immediately preceding study enrollment
  • History of surgery in the past 12 months for pelvic organ prolapse, stress urinary incontinence, urgency urinary incontinence, or fecal or flatal incontinence
  • Patient's primary language is not English

Study Design

Enrollment

40 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Taking pumpkin seed extract

Upon a patient's enrollment into the study and completion of initial study questionnaires, a research team member will provide the patient with a single bottle of pumpkin seed oil extract. Enrolled patients will be instructed to initiate using the pumpkin seed oil extract starting the day they receive the supplement. Patients will start taking one pill by mouth per day for 12 weeks. They will also be advised to contact their urogynecologist for follow-up if they have not noticed improvement in their bladder health following 3 months of use. Furthermore, they will be counseled about not starting new medications or supplements during their time as a study participant and not sharing their pumpkin seed oil extract with anyone else during their time as a study participant.

Interventions

Pumpkin Seed Extract

This is the only intervention

Primary outcome measure

  • LURN-SI [ Time Frame: 12 weeks ]

Central Contacts and Locations

Central contacts

Julia Geynisman-Tan, MD

312-926-9929Julia.Geynisman-Tan@nm.org

Locations

Northwestern University

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Julia Geynisman-Tan, MD

312-926-9929julia.geynisman-tan@nm.org

More Information

Sponsor

Northwestern University

Last update posted

Apr 23, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Northwestern University on 2026-04-23.