Recruiting

Smoking Cessation

Sponsor:

Dana-Farber Cancer Institute

Code:

NCT06945120

Conditions

Smoking Cessation

Smoking Behaviors

Smoking, Tobacco

Smoking, Cigarette

Smoking (Tobacco) Addiction

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

ACT Lung Health Intervention

Study Details

Brief summary:

This study aims to test a counseling and educational program designed to improve lung health through smoking cessation for Chinese and Korean American smokers at high risk for lung cancer.

Conditions

Smoking Cessation

Smoking Behaviors

Smoking, Tobacco

Smoking, Cigarette

Smoking (Tobacco) Addiction

Study ID

NCT06945120

Start date

Nov 4, 2025

Status verified date

Nov, 2025

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Nov 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Self-identify as either Chinese or Korean
  • Speak either Korean, Mandarin, or English
  • Are 18 years of age or older
  • Are current smokers (i.e., have smoked at least 100 traditional cigarettes ever and have smoked at least one traditional cigarette within the prior 30 days)
  • Will live in the United States for the next 12 months

Exclusion Criteria:

  • Hospitalization due to a serious mental illness (e.g., psychotic disorders) during the prior 6 months.
  • We will not include any of the following special populations:

  • Adults unable to consent.
  • Adults younger than 50 or older than 80 years
  • Individuals who are not yet adults (infants, children, teenagers)
  • Pregnant women
  • Prisoners

Study Design

Enrollment

50 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

experimental: Group A: ACT Lung Health Intervention

Participants will be randomized 1:1 in blocks, stratified by ethnicity and readiness to quit smoking and will complete:

  • Baseline assessment
  • Eight telephone or video counseling sessions over 8 weeks
  • Nicotine replacement therapy (NRT) patches, gums and lozenges will be provided
  • Written educational materials on lung cancer screening will be provided
  • Assessments at 1, 3, and 6 months
  • 3 month saliva test
  • 6 month saliva test

no intervention: Group B: Standard Care

Participants will be randomized 1:1 in blocks, stratified by ethnicity and readiness to quit smoking and will complete:

  • Baseline assessment
  • Six telephone or video counseling sessions over 8 weeks
  • Nicotine replacement therapy (NRT) patches, gums and lozenges will be provided
  • Written educational materials on lung cancer screening will be provided
  • Assessments at 1, 3, and 6 months
  • 3 month saliva test
  • 6 month saliva test

Interventions

ACT Lung Health Intervention

An Asian culture-tailored lung health intervention, which includes individual counseling sessions, family coaching, provision of nicotine replacement therapy (NRT) in the form of patches, lozenges, or chewing gum, and educational materials about low-dose computed tomography (LDCT) for lung cancer screening. The eight weekly, counseling sessions with study staff will be conducted via phone call or the Zoom web-conferencing platform.

Primary outcome measure

  • Biochemically Verified 7-Day Point Prevalence Smoking Abstinence at 6 Months (Group A) [ Time Frame: 6 months post-baseline assessment ]
  • Biochemically Verified 7-Day Point Prevalence Smoking Abstinence at 6 Months (Group B) [ Time Frame: 6 months post-baseline assessment ]

Central Contacts and Locations

Central contacts

Mary Cooley, PhD

617-632-5096mary_cooley@dfci.harvard.edu

Barbara Halpenny, MA, MSW

617-582-7124barbara_halpenny@dfci.harvard.edu

Locations

Dana-Farber Cancer Institute

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Mary Cooley, PhD

617-632-5096Mary_cooley@dfci.harvard.edu

Barbara Halpenny, MA, MSW

617-582-7124barbara_halpenny@dfci.harvard.edu

University of Massachusetts-Boston

Recruiting

Boston, Massachusetts, United States, 02125

Contacts

Sun Kim, PhD, RN

sun.kim@umb.edu

Sohyon Pak, MS

sohyon.pak001@umb.edu

Principal Investigator:

Sun Kim, PhD, RN

More Information

Sponsor

Dana-Farber Cancer Institute

Last update posted

Mar 13, 2026

Last verified

Nov, 2025

Keywords

  • Smoking Cessation
  • Lung Cancer Screening
  • Smoking (Tobacco) Addiction
  • Smoking, Cigarette
  • Smoking, Tobacco
  • Smoking Behaviors

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Dana-Farber Cancer Institute on 2026-03-13.