Recruiting

Precision Exercise

Sponsor:

University of Utah

Code:

NCT06945484

Conditions

NSCLC Stage II

NSCLC, Stage III

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Precision Exercise Regimen for Cancer Care (PERCC)

Study Details

Brief summary:

This study is designed to evaluate whether a precision exercise regimen is feasible to implement within cancer populations, specifically stage II-III primary lung cancer patients receiving multimodal therapy, and delivered through telehealth.

Conditions

NSCLC Stage II

NSCLC, Stage III

Study ID

NCT06945484

Start date

Nov 21, 2025

Status verified date

Jul, 2025

Completion date

Dec, 2030

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Ages 18 and older at time of diagnosis
  • Patient diagnosed with stage II and III non-small cell lung cancer (NSCLC)
  • Patient receives either neoadjuvant chemotherapy or immunotherapy and surgery
  • Patient able to follow direction and complete questionnaires in English or Spanish
  • Patient agrees to complete the PERCC intervention

Exclusion Criteria:

  • Morbidly obese (BMI >40 kg/m2 ) or anorexic (BMI <17.5 kg/m2 )
  • Abnormalities on screening physical exam per study physicians or physical therapist to contraindicate participation in exercise program compliance
  • Alcohol or drug abuse, significant mental or emotional problems that would interfere with compliance (assessed by NCCN Distress Thermometer)
  • Patient scheduled to receive single modality cancer treatment (unimodal therapy), scheduled to begin treatment within 2 weeks of the pre-treatment clinic visit, or for whom treatment has already started

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Precision Exercise Regimen for Cancer Care (PERCC)

Participants will engage in PERCC starting at least two weeks prior to receiving their first neoadjuvant treatment for lung cancer and continuing until two months after receiving surgical treatment.

Interventions

Precision Exercise Regimen for Cancer Care (PERCC)

PERCC has exercise modes including basic transfer and calisthenics mobility, aerobic, and resistance exercises, and will be performed in various postures (supine, sitting, standing, and walking) with variable challenges (level walking, bending, inclines, steps, and squatting). Each participant will complete one supervised, home-based exercise training session per week, delivered through telehealth, that will focus on the resistance exercise prescription. Other unsupervised exercise training sessions will focus on the aerobic exercise prescription and will be completed individually

Primary outcome measure

  • Feasibility - Recruitment and Retention [ Time Frame: up to two months post-surgery ]

Central Contacts and Locations

Central contacts

Thomas Varghese, MD, MS, MBA, FACS

801-581-5311thomas.varghese@hsc.utah.edu

Cornelia Ulrich, MS, PhD

801-213-5716neli.ulrich@hci.utah.edu

Locations

University of Texas Medical Branch at Galveston

Recruiting

Galveston, Texas, United States, 77555

Contacts

Rebecca Geck, MSN/MPH

409-266-0496raschaef@utmb.edu

Huntsman Cancer Institute

Recruiting

Salt Lake City, Utah, United States, 84112

Contacts

Cornelia Ulrich, MS, PhD

neli.ulrich@hci.utah.edu

More Information

Sponsor

University of Utah

Last update posted

Feb 3, 2026

Last verified

Jul, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Utah on 2026-02-03.