Recruiting

Observational Study

Sponsor:

University of Minnesota

Code:

NCT06948162

Conditions

Dental Crowding

Dental Occlusion, Traumatic

Endodontic Disease

Orthodontic Treatment

Endodontic Lesions

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

dental-dedicated MRI (ddMRI)

Study Details

Brief summary:

This description observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images. The standard clinical dental images consist of radiographs, such as bitewings, periapical, panoramic, cone-beam CT, and medical CT, as well medical MRIs of the temporomandibular joints (TMJ).The conceptualization of research questions, study designing, and interpretation of imaging data has and will involve content expertise in all ddMRI research.

Conditions

Dental Crowding

Dental Occlusion, Traumatic

Endodontic Disease

Orthodontic Treatment

Endodontic Lesions

Study ID

NCT06948162

Start date

Mar 17, 2025

Status verified date

Aug, 2026

Completion date

Aug 31, 2028

Anticipated

Primary completion date

Mar 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Patient Age: 18 years old or older
2. Receiving imaging for routine dental care
3. Does not have a serious medical condition
4. Is not pregnant or is not potentially pregnant
5. Is willing and able to give consent in English
6. Has the ability to manage their own calendar and schedule appointments
7. Willing to have a separate 2-hour appointment to have an MRI

Exclusion Criteria:

1. Unable to consent to participant in English
2. Serious health condition, which includes but not limited to renal failure/on dialysis, unstable heart disease (uncontrolled arrhythmia, cardiomyopathy and/or unable to lay flat, within 1 month of cardiac catheterization or myocardial infarction), unstable cerebral vascular disease (within 1 month of stroke and/or stent placement), diabetes (type I or II) not controlled by medication or diet, uncontrolled seizures, uncontrolled hyperthyroidism, non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema), uncontrolled movement disorder, and liver failure
3. Pregnant and/or intending to become pregnant,
4. Prisoner and/or not able to manage their own scheduling
5. Screen positive on MR safety questionnaire, specifically including people that have worked with or otherwise been exposed to metal particles and have the potential for such particles to be embedded within them.

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Arms

Dental patients

Dental patients receiving care that have imaging a part of routine care

Interventions

dental-dedicated MRI (ddMRI)

This descriptive observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images.

Primary outcome measure

  • Feasibility and Safety Assessment of ddMRI in Dental Patients [ Time Frame: 1 year ]
  • Diagnostic Quality Assessment of ddMRI in Dental Patients [ Time Frame: 1 year ]
  • Anatomical landmark identification and inflammation detection [ Time Frame: 3 years ]

Central Contacts and Locations

Central contacts

Kelli Trauger, MS, DH, RF

612-624-2231ohcrc@umn.edu

Locations

Orofacial MRI Center(OMRIC), University of Minnesota, School of Dentistry, Malcolm Moos Health Sciences Tower, 515 Delaware St. SE,

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

Rania Nuwailati, BDS, MS, PhD

612-626-8431Nuwai003@umn.edu

Principal Investigator:

Kristin Artinger, PhD

More Information

Sponsor

University of Minnesota

Last update posted

Aug 25, 2026

Last verified

Aug, 2026

Keywords

  • Diagnosis
  • Magnetic resonance imaging
  • Spatial Behavior
  • Malocclusion
  • Behavior
  • Tooth Diseases
  • Stomatognathic Diseases
  • Facial Pain
  • Neurologic Manifestations
  • Pain
  • Pathological Conditions, Signs and Symptoms
  • Dental Occlusion, Traumatic
  • Crowding
  • Dental Pulp Diseases
  • Tooth extraction
  • Periodontitis
  • Histopathalogy
  • Local anesthesia

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2026-08-25.