Recruiting

Peanuts

Sponsor:

Rutgers, The State University of New Jersey

Code:

NCT06949280

Conditions

Weight Loss

Bone Density

Obesity and Overweight

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Interventions

Peanut Snack Experimental

Nut-free Snack

Study Details

Brief summary:

The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice but are not consumed frequently enough in older adults. Studies have shown that regular nut consumption is associated with lower adiposity and reduced weight gain, and several dietary pattern studies indicate that nuts and legumes are associated with better bone health. In addition, our preliminary translational data indicates that a higher monounsaturated fatty acid (MUFA) intake is associated with improved bone mineral density (BMD) and quality. Given these findings, the proposed study aims to examine the impact of consuming peanut products on bone health, metabolic health (e.g., serum glucose, insulin, lipids and inflammation), markers of brain and sleep health, and physical function in overweight and obese older adults before and after a six-month weight loss intervention using a randomized controlled design. The results of this study have the potential to provide valuable insights into the role of peanuts as a sources of fatty acids in promoting health and preventing disease in at-risk adults.

Conditions

Weight Loss

Bone Density

Obesity and Overweight

Study ID

NCT06949280

Start date

Oct 30, 2025

Status verified date

May, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Men and postmenopausal women (>2 years since last menses), ages 50-75 years
  • Body mass index (25-42 kg/m2) or evidence of pre-clinical obesity.
  • Agree to be randomly assigned to consume a daily peanut snack or nut-free snack for 24 weeks
  • Must attend on-site visits (about 10) in New Brunswick, NJ, USA (transportation/reimbursement for travel not included)

Exclusion Criteria:

  • Peanut allergies or intolerances
  • Participants with >5% weight loss in the past 6 months or extreme dietary/physical activity habits
  • An inability to follow the experimental intervention or to perform the required specimen collections.
  • Individuals with significant psychiatric or food disorders.
  • Current diagnosis, or history of cancer in past 3 years.
  • Current diagnosis or history of bone diseases, type I or II diabetes, gastrointestinal disease, hyperparathyroidism, untreated thyroid disease, significant immune, hepatic, cardiac, or renal disease.
  • Uncontrolled hypertension or hyperlipidemia in abnormal ranges.
  • History of surgery in the past 6 months or surgical procedure for weight loss in the past 3 years.
  • Regular use of medications that affect bone metabolism, including bisphosphonates or hormone replacement.
  • Regular use of medications for that affect the gastrointestinal tract including incretin mimetics, cholecystitis, urinary tract infection, severe organic diseases including coronary heart disease, myocardial infarction, infectious diseases including pulmonary tuberculosis and AIDS.
  • Antibiotic use in the past month
  • Alcohol or illicit drug abuse
  • Any other condition deemed by the Research Physician that would prevent participation in the study, e.g. participation in another clinical research project that may interfere with the results of this study.
  • Participation in another clinical interventional research trial

Study Design

Enrollment

44 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Peanut

Peanut products

active comparator: Nut-free snack

Grain snack (nut-free)

Interventions

Peanut Snack Experimental

Subjects will receive a daily peanut snack and nutrition education-behavior modification instructions for weight loss

Nut-free Snack

Subjects will receive a daily peanut snack and nutrition education-behavior modification instructions for weight loss

Primary outcome measure

  • Bone Mineral Density (BMD - hip) [ Time Frame: Change from baseline to 24 weeks ]

Central Contacts and Locations

Central contacts

Locations

Rutgers University - NJ Inst Food Nutrition & Health

Recruiting

New Brunswick, New Jersey, United States, 08901

Contacts

More Information

Sponsor

Rutgers, The State University of New Jersey

Last update posted

May 13, 2026

Last verified

May, 2026

Keywords

  • weight loss
  • adults
  • bone
  • cognition
  • metabolic health
  • sleep
  • peanut
  • Monounsaturated fatty acid

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Rutgers, The State University of New Jersey on 2026-05-13.