Recruiting

Observational Study

Sponsor:

Michigan State University

Code:

NCT06951516

Conditions

Down Syndrome

Eligibility Criteria

Sex: All

Age: 2 - 7

Healthy Volunteers: Not accepted

Interventions

Linguistic simplification

Study Details

Brief summary:

The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with Down syndrome (DS). The overall objective is to determine how single-word and telegraphic simplification affects real-time language processing and word learning in young children with DS (relative to full, grammatical utterances). The proposed project will investigate three specific aims: 1) Determine how single-word and telegraphic simplification affects language processing. 2) Determine how single-word and telegraphic simplification affects word learning. 3) Evaluate child characteristics that may moderate the effects of linguistic simplification on language processing and word learning. Aim 1 will test the hypothesis that children with DS will process grammatical utterances faster and more accurately than telegraphic or single-word utterances. Aim 2 will test the hypothesis that overall, children will demonstrate better word learning in the grammatical compared to the single-word and telegraphic conditions. Aim 3 will test the hypothesis that receptive language and nonverbal cognitive abilities will be significant moderators, such that children with stronger linguistic and cognitive skills will show the greatest benefit from grammatical input but children with lower linguistic and cognitive scores will perform similarly across conditions.

Conditions

Down Syndrome

Study ID

NCT06951516

Start date

Jan 1, 2025

Status verified date

Jun, 2026

Completion date

May 31, 2027

Anticipated

Primary completion date

May 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 2 - 7

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Down syndrome

English as primary language

2-7 years old

Exclusion Criteria:

  • Acquired brain injury

Cerebral palsy

Uncorrected vision or hearing impairment

Study Design

Enrollment

30 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Utterance Type

This study uses a within-participant experimental manipulation. All participants will be exposed to all utterances types (across trials).

Interventions

Linguistic simplification

Children will participate in screen-based language processing and word learning tasks in which they hear utterances with different types and amounts of linguistic simplification (i.e., a within-group manipulation).

Primary outcome measure

  • Gaze location on Looking-While-Listening (LWL) tasks [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Courtney Venker, PhD

517-884-2259cvenker@msu.edu

Jennifer Johnson, M.S.

517-884-2259jrj@msu.edu

Locations

Michigan State University

Recruiting

East Lansing, Michigan, United States, 48824

Contacts

Courtney Venker, PhD

5178842259cvenker@msu.edu

More Information

Sponsor

Michigan State University

Last update posted

Jun 12, 2026

Last verified

Jun, 2026

Keywords

  • Down syndrome
  • language development
  • language processing
  • language input

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Michigan State University on 2026-06-12.