Recruiting

Aerobic Fitness

Sponsor:

University of Vermont Medical Center

Code:

NCT06951620

Conditions

Aerobic Capacity

High Intensity Interval Training

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Not accepted

Interventions

HIIT

MICT

Study Details

Brief summary:

Hospitalization and treatment for cardiovascular disease is one of the main contributors to disability in older adults. Moderate intensity continuous aerobic and resistance training have been the cornerstone of cardiac rehabilitation (CR) for decades to remediate hospital-acquired functional deficits, but some groups receive less or minimal functional benefit from this training. The proposed studies seek to optimize recovery of aerobic fitness and physical function among older cardiac patients using a novel high intensity training regimen with the long-term goal of reducing subsequent disability and improving clinical outcomes.

Conditions

Aerobic Capacity

High Intensity Interval Training

Study ID

NCT06951620

Start date

Apr 17, 2025

Status verified date

Jun, 2025

Completion date

Jun 30, 2029

Anticipated

Primary completion date

Mar 15, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • >65 years old
  • ambulatory
  • enrolled in CR at our center following a recent clinical diagnosis of myocardial infarction or percutaneous intervention will be recruited

Exclusion Criteria:

  • have an active malignancy (excluding non-melanoma skin cancer or low grade prostate cancer under surveillance)
  • unwilling to comply with the exercise prescription they may be assigned to
  • have a submaximal performance on entry exercise tolerance test, defined as respiratory exchange ratio <1.0

Study Design

Enrollment

114 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Intervention Group

Patients who recently experienced a myocardial infarction (MI) or percutaneous intervention (PCI; angioplasty, stent placement or valve replacement) and enroll in Phase 2 Cardiac Rehabilitation (CR) may be randomized to High intensity training

experimental: Usual Care Group

Patients who recently experienced a myocardial infarction (MI) or percutaneous intervention (PCI; angioplasty, stent placement or valve replacement) and enroll in Phase 2 Cardiac Rehabilitation (CR) may be randomized to Moderate intensity training

Interventions

HIIT

Patients who recently experienced a myocardial infarction (MI) or percutaneous intervention (PCI; angioplasty, stent placement or valve replacement) and enroll in Phase 2 Cardiac Rehabilitation (CR) may be randomized to High intensity training (HIIT)

MICT

Patients who recently experienced a myocardial infarction (MI) or percutaneous intervention (PCI; angioplasty, stent placement or valve replacement) and enroll in Phase 2 Cardiac Rehabilitation (CR) may be randomized to Moderate intensity training

Primary outcome measure

  • Change in Aerobic fitness [ Time Frame: Within 4 months of the intake assessment ]
  • Change in 30 sec sit-to-stand test (STS) [ Time Frame: Within 4 months of the intake assessment ]

Central Contacts and Locations

Central contacts

Patrick Savage, Research Coordinator

802-847-4545patrick.savage@uvmhealth.org

Locations

UVMMC Cardiac Rehabilitation

Recruiting

South Burlington, Vermont, United States, 05403

Contacts

Sheena Barnes Clinic Supervisor

802-847-4600sheena.barnes@uvmhealth.org

Principal Investigator:

Sherrie Khadanga PI, MD

More Information

Sponsor

University of Vermont Medical Center

Last update posted

Jun 8, 2025

Last verified

Jun, 2025

Keywords

  • cardiac rehabilitation
  • HIIT
  • MICT
  • exercise in older adults
  • aerobic capacity

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Vermont Medical Center on 2025-06-08.