Recruiting

Adductor Canal Block & IPACK

Sponsor:

NYU Langone Health

Code:

NCT06952556

Conditions

Analgesia

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

ACB

IPACK block

Study Details

Brief summary:

A randomized, single-blind, single-center study measuring the effects of adductor canal block combined with IPACK infiltration compared to adductor canal block alone on post-operative pain and opioid consumption in patients undergoing high tibial osteotomy (HTO)/distal femoral osteotomy (DFO)/tibial tubercle osteotomy (TTO).

Conditions

Analgesia

Study ID

NCT06952556

Start date

Apr 28, 2025

Status verified date

Feb, 2026

Completion date

Jun 28, 2027

Anticipated

Primary completion date

Apr 28, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients between 18 and 75 years of age
  • Patients undergoing HTO/DFO/TTO.
  • American Society of Anesthesiologists (ASA) I or II

Exclusion Criteria:

  • Patients younger than 18 and older than 75.
  • Patients with multi-ligament injury
  • Patients undergoing concomitant cartilage procedure or ACLR.
  • Patients with a history of chronic pain that have used opioids for pain management for 3 months or longer.
  • Patients who are allergic to oxycodone;
  • Patients with diagnosed or self-reported cognitive dysfunction;
  • Patients with a history of neurologic disorder that can interfere with pain sensation;
  • Patients with a history of drug or recorded alcohol abuse;
  • Patients who are unable to understand or follow instructions;
  • Patients with severe liver disease, renal insufficiency, congestive heart failure, and/or significant heart disease;
  • Patients with an allergy or contraindication to any of the medications used in the study, or patients with a contraindication to any study procedures;
  • Patients with a BMI over 45;
  • Any patient that the investigators feel cannot comply with all study related procedures;
  • Any pregnant patient; assessed via urine pregnancy test in the preoperative area as part of standard preoperative surgical protocol;

Study Design

Enrollment

100 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Adductor Canal Block (ACB) + IPACK Block

Participants receive ACB with IPACK block.

active comparator: Isolated Adductor Canal Block

Participants receive ACB only.

Interventions

ACB

15 mL of 0.25% Bupivacaine block of the saphenous nerve injected under ultrasound guidance via adductor canal.

IPACK block

IPACK block with 20 mL of 0.25% Bupivacaine injected into the Interspace between the Popliteal Artery and Capsule of the Knee

Primary outcome measure

  • Opioid Utilization for First 24 Hours Post-Surgery [ Time Frame: Up to Hour 24 Post-Procedure (Post-Operative Day 1 [POD 1]) ]

Central Contacts and Locations

Central contacts

Laith Jazrawi, MD

646-501-7223Laith.jazrawi@nyulangone.org

Locations

NYU Langone Health

Recruiting

New York, New York, United States, 10016

More Information

Sponsor

NYU Langone Health

Last update posted

Feb 25, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by NYU Langone Health on 2026-02-25.