Recruiting

Observational Study

Sponsor:

Johns Hopkins University

Code:

NCT06954402

Conditions

Opioid Use Disorder

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Acute Stress Intervention (MAST-based)

Non-Stress Intervention (NST-based)

Study Details

Brief summary:

The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if objective tasks that measure cognitive, emotional, and control aspects of resilience match up with self-reported resilience during stress and non-stress situations.

Conditions

Opioid Use Disorder

Study ID

NCT06954402

Start date

May 29, 2026

Status verified date

Jun, 2026

Completion date

Apr 30, 2029

Anticipated

Primary completion date

Apr 30, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Can provide informed consent and can comply with study procedures
2. Adults aged ≥18 years
3. Meet Diagnostic and Statistical Manual (DSM-5) criteria for current opioid use disorder or are currently receiving pharmacotherapy for the treatment of OUD (e.g. methadone or buprenorphine maintenance treatment \[remission\])
4. Urine sample that tests positive for opioids
5. Test negative for pregnancy at screening (females only)

Exclusion Criteria:

1. Being pregnant or breastfeeding
2. Significant mental health or physical disorder, or life circumstances, that is judged by the investigators to interfere with study participation

Study Design

Enrollment

125 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Stress-First Sequence

Participants in this arm will first undergo the stress condition using the Maastricht Acute Stress Test (MAST) and then complete the non-stress condition (NST) in a subsequent session.

experimental: Non-Stress-First Sequence

Participants in this arm will first complete the non-stress condition (NST) and then undergo the stress condition using the Maastricht Acute Stress Test (MAST) in a subsequent session.

Interventions

Acute Stress Intervention (MAST-based)

This intervention uses the Maastricht Acute Stress Test (MAST) to induce an acute stress response. Participants are exposed to standardized stress tasks while performing laboratory-based assessments of cognitive, emotional, and control aspects of resilience.

Non-Stress Intervention (NST-based)

In this control intervention, participants complete the same battery of laboratory tasks without exposure to the acute stressor.

Primary outcome measure

  • Self-Reported Trait Resilience as assessed by Connor-Davidson Resilience Scale 25 (CD-RISC-25) [ Time Frame: Immediately after completing the task ]
  • Cognitive Flexibility: Stroop Color-Word Test reaction time [ Time Frame: Immediately after completing the task ]
  • Emotional Flexibility: Emotional Stroop Task reaction time [ Time Frame: Immediately after completing the task ]
  • Perceived Controllability (Controllable) assessed by Social Controllability Task (SCT) [ Time Frame: Immediately after completing the task ]

Central Contacts and Locations

Central contacts

Suky Martinez, PhD

410-550-0007smart209@jh.edu

Locations

Johns Hopkins University Bayview Medical Campus

Recruiting

Baltimore, Maryland, United States, 21224

Contacts

Alec Zhang, BS

410-550-4121smart209@jh.edu

More Information

Sponsor

Johns Hopkins University

Last update posted

Jun 23, 2026

Last verified

Jun, 2026

Keywords

  • opioids
  • opioid use disorder
  • stress

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-06-23.