Recruiting

TMS

Sponsor:

Icahn School of Medicine at Mount Sinai

Code:

NCT06960083

Conditions

Misophonia

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

Transcranial Magnetic Stimulation (TMS)

Study Details

Brief summary:

The purpose of the project is to assess the efficacy of parietal transcranial magnetic stimulation in misophonia. N=60 participants will undergo two transcranial magnetic stimulation sessions: one inhibitory and another excitatory. During both sessions, the parietal region will be stimulated. Participants will perform computerized tasks immediately before and after the stimulation, while EEG, heart rate, and skin temperature will be recorded. These recordings will be used to assess if TMS can be used to improve tolerance to misophonia triggers.

Conditions

Misophonia

Study ID

NCT06960083

Start date

Sep 2, 2025

Status verified date

Jul, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger/outbursts, or fear.
  • Must be between the ages of 18 - 55.
  • Must be fluent in English since the study's instructions, surveys, and tasks will be in English.

Exclusion Criteria:

  • Epilepsy or previous episode of convulsion or seizure.
  • Previous episode of fainting spell or syncope.
  • Head trauma.
  • Hearing problems.
  • Cochlear implant.
  • Metal in the brain, skull, or anywhere else in the body (e.g., splinters, fragments, clips, etc.).
  • Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS).
  • Presence of cardiac pacemaker or intracardiac lines.
  • Presence of medication infusion device.
  • Use of pro-convulsant or epileptogenic medications.
  • Pregnancy. The risks associated with TMS exposure during gestation have not been studied extensively. We wish to safeguard the health of potential participants and their children.
  • Lactation. The risks associated with TMS during lactation and its effects on infant development have not been studied. We wish to safeguard the health of potential participants and their children.
  • Presence of Mania, Psychosis, Antisocial Personality Disorder, Borderline Personality Disorder, and Suicidal Ideation.

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Inhibitory-Excitatory (IE) then Excitatory-Inhibitory (EI)

Participants in this group will receive an inhibitory TMS in the first session and an excitatory TMS in the second session. The two sessions will be separated by 72 hours.

active comparator: Excitatory-Inhibitory (EI) then Inhibitory-Excitatory (IE)

Participants in this group will receive an excitatory TMS in the first session and an inhibitory TMS in the second session. The two sessions will be separated by 72 hours.

Interventions

Transcranial Magnetic Stimulation (TMS)

Transcranial Magnetic Stimulation (TMS) is an FDA-approved non-invasive brain stimulation technology. It is currently used for treating depression. Applications to other disorders such as OCD and anxiety using TMS are currently under investigation. TMS will be administered for 25 minutes.

Primary outcome measure

  • Unpleasantness Rating Scale [ Time Frame: after each session, 72 hours apart (each session is 2 hours) ]

Central Contacts and Locations

Central contacts

Shama Patel

347-670-4878shama.patel@mssm.edu

Parul Jain, PhD

212-824-8992parul.jain@mssm.edu

Locations

Mount Sinai West

Recruiting

New York, New York, United States, 10022

Contacts

Daniela Schiller, PhD

daniela.schiller@mssm.edu

Martijn Figee, MD, PhD

martijn.figee@mssm.edu

Principal Investigator:

Parul Jain

More Information

Sponsor

Icahn School of Medicine at Mount Sinai

Last update posted

Jul 21, 2026

Last verified

Jul, 2026

Keywords

  • Misophonia
  • Transcranial Magnetic Stimulation
  • Crossover trial
  • Single session
  • EEG

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Icahn School of Medicine at Mount Sinai on 2026-07-21.