Recruiting

Mosaic & Educational Website

Sponsor:

Northwestern University

Code:

NCT06960993

Conditions

Hematologic Malignancy

Stem Cell Transplant

Bone Marrow Transplant

Leukemia

Lymphoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Intervention website

Enhanced Usual Care (Control) Website

Study Details

Brief summary:

The goal of this clinical trial is to learn if using an intervention website (Mosaic) improves selected patient-reported outcomes in adult blood cancer patients undergoing allogeneic or autologous stem cell transplant, compared to using an educational website (control group). Patients will be recruited prior to their scheduled transplant, then randomized to use one of these two study websites throughout the study. They will complete five assessments during the study: one before transplant (baseline) and four after transplant (2, 4, 6, and 8 month follow-ups).

The main questions this trial aims to answer are:

1. Compared to patients using the control group website, do patients using the intervention website report greater improvements in general psychological distress, cancer treatment-related distress, physical symptoms, and health-related quality of life?
2. Are these benefits at least partially explained by improvements in perceived preparedness, self-efficacy, and approach coping and/or reductions in avoidant coping and perceived stress?
3. Do some patients benefit more from using the intervention website than others? Specifically, we will examine whether patients' primary language (English/Spanish) and their initial psychological distress are related to the benefit they get from using the intervention website. We will also explore effects of sex, race, ethnicity, and transplant type.

Conditions

Hematologic Malignancy

Stem Cell Transplant

Bone Marrow Transplant

Leukemia

Lymphoma

Study ID

NCT06960993

Start date

Apr 28, 2025

Status verified date

Jul, 2026

Completion date

Feb 1, 2030

Anticipated

Primary completion date

Jun 12, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosed with a hematologic cancer according to medical records
  • Scheduled for or preparing for scheduling of an allogeneic or autologous stem cell transplant at one of our study sites
  • Aged 18 or older (no upper limit)
  • English or Spanish Proficient
  • Interested in using a website to learn about stem cell transplant
  • Ability to understand and willingness to sign an informed consent document and comply with all study procedures

Exclusion Criteria:

  • Currently participating in a behavioral intervention targeting distress, health-related quality of life, or symptoms
  • Undergoing the first in a planned tandem stem cell transplant
  • Unable to provide meaningful consent (severe cognitive impairment or language difficulties)

Study Design

Enrollment

356 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Intervention Website

The intervention website pairs experiential information about transplant with (1) coordinated coping and stress management training and resources to support skill practice and (2) an educational component that includes educational content and links to well-established, vetted websites that provide broader, provider-reviewed information about the transplant process and links to psychosocial resources. Participants can toggle between English and Spanish content, and they will be able to use this website throughout their participation in the study.

active comparator: Enhanced Usual Care (Control) website

The control website pairs (1) coordinated coping and stress management training and resources to support skill practice with (2) an educational component that includes educational content and links to well-established, vetted websites that provide broader, provider-reviewed information about the transplant process and links to psychosocial resources, using the same technology platform and look/feel as the intervention website.

Participants can toggle between the English and Spanish versions of the website and they will be able to use this website throughout their participation in the study.

Interventions

Intervention website

Website that includes experiential information, stress and coping resources, educational content, and links to trusted websites with additional educational content and links to psychosocial resources for transplant recipients and caregivers.

Enhanced Usual Care (Control) Website

Website that includes stress and coping resources, educational content, and links to trusted websites with additional educational content and links to psychosocial resources for transplant recipients and caregivers.

Primary outcome measure

  • Improvement in general psychological distress [ Time Frame: Baseline to 2 months post-transplant ]

Central Contacts and Locations

Central contacts

Alexandra Psihogios, PhD

312-503-3577Alex.psihogios@northwestern.edu

Sonia Zavala

312-503-8134sonia.zavala@northwestern.edu

Locations

Georgetown University School of Medicine

Recruiting

Washington D.C., District of Columbia, United States, 20057

Contacts

Kristi Graves, PhD

202-687-1591kristi.graves@georgetown.edu

Northwestern University Feinberg School of Medicine

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Alexandra Psihogios, PhD

312-503-3577alex.psihogios@northwestern.edu

Sonia Zavala

312-503-8134sonia.zavala@northwestern.edu

Hackensack Meridian Health

Recruiting

Nutley, New Jersey, United States, 07110

Contacts

Heather Derry-Vick, PhD

201-880-3100heather.derryvick@hmh-cdi.org

More Information

Sponsor

Northwestern University

Last update posted

Aug 3, 2026

Last verified

Jul, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Northwestern University on 2026-08-03.