Recruiting

Buprenorphine vs. Telehealth

Sponsor:

UCLA

Code:

NCT06961058

Conditions

Opioid Use Disorder

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

referral to telehealth treatment

referral to in person treatment

Study Details

Brief summary:

Main study objective: compare long-term buprenorphine treatment outcomes for patients who start buprenorphine for opioid use disorder (OUD) in the emergency department and are then referred to get outpatient buprenorphine treatment either via telehealth or at an in-person clinic.

Researchers will:

Compare rates of establishing outpatient OUD treatment, how long patients stay on buprenorphine, and patients' experience with care to determine whether patient experiences and outcomes are better for patients referred to telehealth treatment versus patients patients referred to in-person treatment after they leave the emergency department.

Participants will:

Be recruited from 3 different hospital emergency departments.

Answer questionnaires at baseline and then 1, 3, 6, and 9 months after their initial emergency department visit.

Conditions

Opioid Use Disorder

Study ID

NCT06961058

Start date

Jun 3, 2025

Status verified date

Jun, 2026

Completion date

Sep 1, 2029

Anticipated

Primary completion date

Jun 1, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult patients who present to the emergency department and receive buprenorphine (either administered or prescribed) to treat OUD
  • do not have an established outpatient clinic where they will get buprenorphine when they leave the emergency department

Exclusion Criteria:

  • inability to give consent
  • patients living in institutions (e.g., nursing homes, prisons)
  • unable to complete questionnaires in either English or Spanish

Study Design

Enrollment

528 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

active comparator: in person

Participants will get treatment via CA Bridge, California's statewide program to provide Emergency Department (ED)-based OUD treatment. When clinicians or staff suspect an ED patient may have OUD, they refer the patient to an ED-based counselor who assesses the patient and engages them in OUD care. All patients with OUD get brief counseling and take-home naloxone. Patients willing to start treatment get buprenorphine (via either ED- or home-based induction), a referral for in-person outpatient OUD treatment at a local outpatient clinic or opioid treatment program, and a "bridge" prescription of buprenorphine to last until their first outpatient appointment. CA Bridge counselors maintain contact with patients for up to 30 days to help them establish outpatient care. This is usual care in study hospitals and in the >80% of California hospitals that participate in CA Bridge.

experimental: telehealth

This arm will comprise the same elements as the "in person" arm except that patients will be referred to get outpatient OUD treatment via telehealth (i.e. phone or video visits). Depending on study site and patient insurance, participants will be referred to get treatment at either a clinic associated with their hospital that offers telehealth OUD treatment or from a digital health company that provides on-demand telehealth OUD treatment and support services via video and phone visits.

Interventions

referral to telehealth treatment

the intervention tested will be referral to get outpatient treatment via telehealth. Participants in the telehealth arm will receive the intervention.

referral to in person treatment

participants in the in person arm will be referred to in person OUD treatment after they leave the ED

Primary outcome measure

  • buprenorphine retention [ Time Frame: 6 months ]

Central Contacts and Locations

Central contacts

Locations

El Centro Regional Medical Center Emergency Department

Recruiting

El Centro, California, United States, 92243

Contacts

University of California Davis Emergency Department

Recruiting

Sacramento, California, United States, 95817

Contacts

Olive View - UCLA Medical Center Emegency Department

Recruiting

Sylmar, California, United States, 91342

Contacts

More Information

Sponsor

University of California, Davis

Last update posted

Jun 29, 2026

Last verified

Jun, 2026

Keywords

  • emergency department
  • buprenorphine
  • telehealth
  • comparative effectiveness

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of California, Davis on 2026-06-29.