Recruiting

Multi-Cancer Detection

Sponsor:

Mayo Clinic

Code:

NCT06962995

Conditions

Cancer

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Accepted

Interventions

Blood Sample

Surveys

Study Details

Brief summary:

This study assesses the incorporation of Multi-Cancer Detection (MCD) testing, designed to detect many types of cancer, into clinical practice to understand both its use and effect in real world practice conditions.

Conditions

Cancer

Study ID

NCT06962995

Start date

May 7, 2025

Status verified date

Mar, 2026

Completion date

Jun 30, 2029

Anticipated

Primary completion date

Jun 30, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Has Mayo Clinic medical record number
  • Has undergone (within last 6 months) or scheduled to undergo a multi-cancer detection test (MCD) as ordered by provider
  • Able to provide informed consent
  • ≥ 21 years old
  • Ability to provide blood sample

Exclusion Criteria:

  • Individuals who have situations that would limit compliance with the study requirements
  • Institutionalized (i.e. Federal Medical Prison)
  • Known pregnancy (self-reported)
  • Currently undergoing active cancer treatment other than adjuvant hormone therapy
  • Invasive cancer diagnosis within the last 3 years

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Arms

Observational

Patients complete surveys and have their medical records reviewed on study. Patients may undergo blood or buccal swab and urine sample collection on study.

Interventions

Blood Sample

Up to 60 mL (about 4-5 Tbsp) of blood may be collected for an initial blood draw and up to 30 mL (about 2-3 Tbsp) may be collected for a second blood draw, 25-45 days after first blood draw. The research blood will be collected at the time of a clinical blood draw, if possible.

Surveys

Participants will complete surveys related to attitudes and beliefs around Multi-Cancer Detection testing.

Primary outcome measure

  • Financial impact of MCD testing [ Time Frame: Up to 5 years ]
  • Positive actionable MCD results [ Time Frame: Up to 5 years ]
  • Psychological Impact of MCD Testing [ Time Frame: Baseline (after receiving MCD results) ]
  • Change in Patient Satisfaction with MCD Test [ Time Frame: Baseline; After receiving MCD results (up to 5 years) ]

Central Contacts and Locations

Central contacts

Clinical Trials Referral Office

855-776-0015mayocliniccancerstudies@mayo.edu

Locations

Mayo Clinic in Arizona

Recruiting

Scottsdale, Arizona, United States, 85259

Contacts

Clinical Trials Referral Office

855-776-0015mayocliniccancerstudies@mayo.edu

Principal Investigator:

Jewel Samadder, MD

Mayo Clinic in Florida

Recruiting

Jacksonville, Florida, United States, 32224-9980

Contacts

Clinical Trials Referral Office

855-776-0015mayocliniccancerstudies@mayo.edu

Principal Investigator:

R. John Presutti, DO

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Clinical Trials Referral Office

855-776-0015mayocliniccancerstudies@mayo.edu

Principal Investigator:

Ryan Hurt, MD, PhD

More Information

Sponsor

Mayo Clinic

Last update posted

Apr 6, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-04-06.