Recruiting

Observational Study

Sponsor:

Hospital for Special Surgery, New York

Code:

NCT06971575

Conditions

Cervical Radiculopathy

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Not accepted

Interventions

Magnetic resonance neurography

Study Details

Brief summary:

This project will study patients with cervical radiculopathy. We will evaluate the combined diagnostic and prognostic value of magnetic resonance neurography (MRN), electrodiagnostic (EDX) studies, and historical and physical clinical elements. Specifically, this project will explore whether these data individually or in combination correlate with response to procedural and non-procedural treatment.

Conditions

Cervical Radiculopathy

Study ID

NCT06971575

Start date

Oct 24, 2023

Status verified date

Apr, 2026

Completion date

Oct, 2026

Anticipated

Primary completion date

Oct, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients presenting with symptoms compatible with acute or subacute unilateral (one-sided) cervical radiculopathy and signs of clinical weakness
  • 18-60 years old at the time of evaluation
  • Symptom onset of 2 to 12 weeks leading up to baseline visit
  • Diagnosis of unilateral cervical radiculopathy, with or without spinal cord compression, based on signs and symptoms, physical exam and supported by MRI findings of radiculopathy (as evidenced by foraminal stenosis/narrowing) based on standard-of-care cervical spine MRI
  • Patients who have undergone or have planned electrodiagnostic testing at HSS prior to surgery

Exclusion Criteria:

  • Prior cervical surgery or instrumentation
  • Those who have had a prior episode of cervical radiculopathy
  • History of peripheral neuropathy or another acute or chronic neurodegenerative condition
  • History of stroke, cerebellar disease, or central nervous system disease
  • Contraindications to undergoing a standard MRI examination (e.g., pregnancy)
  • Patients presenting with bilateral cervical radiculopathy

Study Design

Enrollment

20 participants

Anticipated

Interventions and Outcome Measures

Arms

Cervical Radiculopathy Patients

Patients diagnosed with unilateral cervical radiculopathy and signs of clinical weakness.

Interventions

Magnetic resonance neurography

Patients will undergo a cervical MRI with specialized magnetic resonance neurography sequences to evaluate the extraforaminal cervical nerve roots.

Primary outcome measure

  • Presence of abnormalities on nerve (MRN) imaging [ Time Frame: Baseline ]
  • Relationship between abnormalities on imaging and electrodiagnostic assessment [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

J. Levi Chazen, MD

212-774-7149chazenjl@hss.edu

Carlo Milani, MD

milanic@hss.edu

Locations

Hospital for Special Surgery

Recruiting

New York, New York, United States, 10021

Contacts

J. Levi Chazen

212-774-7149chazenjl@hss.edu

Principal Investigator:

J. Levi Chazen, MD

More Information

Sponsor

Hospital for Special Surgery, New York

Last update posted

Apr 27, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Hospital for Special Surgery, New York on 2026-04-27.