Recruiting

qDSA

Sponsor:

University of Wisconsin, Madison

Code:

NCT06971991

Conditions

Transarterial Embolism

Transarterial Chemoembolization

Radioembolization

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

qDSA Blood Flow Measurement

Study Details

Brief summary:

The purpose of this research is to evaluate a new technique, quantitative digital subtraction angiography (qDSA), to measure blood flow during liver embolization procedures. Liver embolization is a way of treating liver tumors by blocking blood flow to it. The qDSA technique could help doctors ensure the blood flow to the tumor is decreased by the right amount by calculating blood flow before, during, and after the procedure. Up to 20 participants will be enrolled for 1 study visit and data collection for up to 6 months.

Conditions

Transarterial Embolism

Transarterial Chemoembolization

Radioembolization

Study ID

NCT06971991

Start date

Mar 13, 2025

Status verified date

Mar, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Give voluntary, written informed consent to participate in this study and willing to comply with study-related evaluation and procedure schedule

Exclusion Criteria:

  • Pregnancy or breastfeeding
  • Patients with an acute kidney injury or stage IV or V chronic kidney disease (Cr greater than 2.4 or estimated glomerular filtration rate (eGFR) less than 30), unless anuric and on dialysis without expected return of renal function.
  • Patients with an iodinated contrast allergy who cannot be adequately premedicated to receive contrast as part of the embolization procedure.
  • Patients with a physical or psychological condition that would impair study participation.
  • The patient is judged unsuitable for study participation by the Investigator for any other reason

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Screening

Interventions and Outcome Measures

Arms

experimental: Participants Undergoing TAE of the Liver

Interventions

qDSA Blood Flow Measurement

Pre-, mid-, and post-embolization, qDSA and transabdominal US Doppler images will be acquired for research purposes during TAE and TACE procedures. For patients undergoing radioembolization, qDSA and US Doppler images will be acquired during both the preparatory angiogram and therapy angiogram (prior to delivery of the radioactive particles)

Primary outcome measure

  • Number of patients in which qDSA measurements demonstrate successive reductions in hepatic arterial velocity at the pre-, mid-, and post-embolization time points [ Time Frame: data collected pre-embolization, mid-embolization, and post-embolization (up to 1 hour), data processed retrospectively for this measure when data collection is complete (up to 6 months) ]

Central Contacts and Locations

Central contacts

Radiology Coordinators

608-282-8349Radstudy@uwhealth.org

Locations

UW Hospital and Clinics

Recruiting

Madison, Wisconsin, United States, 53792

More Information

Sponsor

University of Wisconsin, Madison

Last update posted

Mar 30, 2026

Last verified

Mar, 2026

Keywords

  • Quantitative digital subtraction angiography (qDSA)
  • Radioembolization
  • TAE
  • TACE

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Wisconsin, Madison on 2026-03-30.