Recruiting

TMS & SFA

Sponsor:

Medical College of Wisconsin

Code:

NCT06974279

Conditions

Aphasia

Stroke

Language

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Precision TMS with SFA

Control TMS with SFA

Study Details

Brief summary:

The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).

Conditions

Aphasia

Stroke

Language

Study ID

NCT06974279

Start date

Sep 1, 2025

Status verified date

Jul, 2026

Completion date

Dec 31, 2036

Anticipated

Primary completion date

Dec 31, 2036

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosed with left hemisphere stroke
  • Consent date >= 1 month after stroke onset
  • Fluent in English
  • 18 years of age or older

Exclusion Criteria:

  • Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing
  • Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)
  • A chronic medical condition that is not treated or is unstable
  • The presence of cardiac stimulators or pacemakers or intracardiac lines, neurostimulators, medication infusion device, any other implants near the scalp (e.g., cochlear implants) or in the eye, metal in the body (e.g., splinters, fragments, clips)
  • Pregnancy
  • History of skull fractures, or skin diseases
  • History of ongoing or unmanaged seizures
  • Presence of factors that potentially decrease seizure thresholds: on pro-convulsant medications, untreated sleep deprivation or insomnia, ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)
  • History of dyslexia or other developmental learning disabilities

Study Design

Enrollment

50 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Precision TMS

SFA will be administered immediately after precision TMS

placebo comparator: Control TMS

SFA will be administered immediately after control TMS

Interventions

Precision TMS with SFA

Excitatory TMS delivered using a precision site finding approach and intermittent theta burst stimulation protocol

Control TMS with SFA

Excitatory TMS using intermittent theta burst stimulation delivered to a control vertex site.

Primary outcome measure

  • Accuracy on a picture naming test [ Time Frame: immediately after and 8-12 weeks after last SFA+TMS treatment ]

Central Contacts and Locations

Central contacts

Sidney Schoenrock, MA

414-955-7579sschoenrock@mcw.edu

Ari Hjelmeseth

414-955-7578ahjelmeseth@mcw.edu

Locations

Medical College of Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Sidney Schoenrock, MA

414-955-7579sschoenrock@mcw.edu

Ari Hjelmeseth

414-955-7578ahjelmeseth@mcw.edu

Principal Investigator:

Priyanka Shah-Basak, PhD

More Information

Sponsor

Medical College of Wisconsin

Last update posted

Jul 10, 2026

Last verified

Jul, 2026

Keywords

  • Aphasia
  • Stroke
  • Language
  • TMS

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Medical College of Wisconsin on 2026-07-10.