Recruiting
Phase 2

Obicetrapib

Sponsor:

NewAmsterdam Pharma

Code:

NCT06982508

Conditions

Antioxidant Absorption

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Obicetrapib 10mg

Placebo

Study Details

Brief summary:

The goal of this clinical trial is to learn if Obicetrapib works to change antioxidant levels in HDL and plasma, as well as retinal tissue. The main questions it aims to answer are:

Do Obicetrapib effect absorption of antioxidants in a person's blood or their eye tissue? Researchers will compare Obicetrapib to a placebo (a look-alike substance that contains no drug) to see if Obicetrapib helps improve a person's ability to absorb antioxidants.

Participants will:

Take Obicetrapib or a placebo every day for 4 months Visit the clinic once every 8 weeks for checkups and tests Have their blood taken and their eyes checked to measure antioxidant levels

Conditions

Antioxidant Absorption

Study ID

NCT06982508

Start date

Sep 9, 2025

Status verified date

Oct, 2025

Completion date

Dec, 2026

Anticipated

Primary completion date

Sep, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Visual acuity > 20/60 in both eyes with or without corrective lenses

Exclusion Criteria:

  • Type 2 diabetes
  • Active liver disease
  • Any clinically significant macular pathology

Study Design

Enrollment

100 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Obicetrapib 10mg

placebo comparator: Placebo

Interventions

Obicetrapib 10mg

Active Drug

Placebo

Placebo Control

Primary outcome measure

  • Sum of Percent Change of Antioxidant Levels within HDL [ Time Frame: 16 Weeks ]

Central Contacts and Locations

Locations

Excellence Medical Research

Recruiting

Miami Gardens, Florida, United States, 33169

Contacts

More Information

Sponsor

NewAmsterdam Pharma

Last update posted

Oct 20, 2025

Last verified

Oct, 2025

Keywords

  • Healthy Volunteer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by NewAmsterdam Pharma on 2025-10-20.