Recruiting

Cannabis UseCannabis Association With Sleep Study

Sponsor:

Oregon Health and Science University

Code:

NCT06982950

Conditions

Sleep

Eligibility Criteria

Sex: All

Age: 21 - 29

Healthy Volunteers: Accepted

Interventions

Manipulation of Sleep Duration

Study Details

Brief summary:

The purpose of this study is to learn more about cannabis use, sleep, and stress, and whether there is any relationship between the three.

Conditions

Sleep

Study ID

NCT06982950

Start date

Mar 1, 2026

Status verified date

Oct, 2026

Completion date

Jun 30, 2032

Anticipated

Primary completion date

Jun 30, 2030

Anticipated

Eligibility Criteria

Sex: All

Age: 21 - 29

Healthy Volunteers: Accepted

Inclusion Criteria:

fluent in English
18.5<BMI<40 kg/m2
no shift work in the last 12 months
no travel across time zones in the last 2 months.

Exclusion Criteria:

Chronic disease-Medical history/prior diagnosis of the following:
cardiometabolic disease (e.g., myocardial infarction, angina, diabetes)
essential hypertension
hepatic impairment
severe obstructive sleep apnea
restless legs syndrome
parasomnia
neurological disease (e.g., early onset dementia)
unstable psychiatric disorders (e.g., bipolar disorder, schizophrenia, major depression with suicidality).
Drug/Alcohol use criteria:
Illicit drugs apart from cannabis or related products are prohibitive.
Volunteers may consume caffeine, however, >3 cups of coffee (or otherwise equivalent of >300mg/day) is prohibitive.
Participants who consume >14 alcoholic drinks/week and/or have a diagnosis (or history) of alcohol use disorder will be excluded (a toxicological urine screen will be conducted to verify reported non-use during the initial screening and on the day of admission to the in-laboratory portion of the study).
Use of prescription or over-the-counter medications or supplements that affect sleep are also exclusionary.
Contraceptives are required for women and will continue to be taken throughout the experiment.
Prior Shift Work:
Volunteers must have no history of working irregular day and night hours, regular night work, or rotating shift work for the 3 months prior to the study.

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Sleep Restriction

After a baseline assessment of sleep, participants in this arm will undergo 2 nights of restricted sleep (4 hour time in bed).

experimental: Sleep Extension

After a baseline assessment of sleep, participants in this arm will undergo 3 nights of an extended sleep opportunity (10 hour time in bed).

Interventions

Manipulation of Sleep Duration

After a baseline assessment of sleep, participants will undergo either 2 nights of restricted sleep (4 hour time in bed) followed by a recovery sleep, OR 3 nights of an extended sleep opportunity (10 hour time in bed)

Primary outcome measure

Daily Cannabis Use Frequency [ Time Frame: Assessed in surveys performed 4 times per day, and across the entire 21-day study ]
Wake After Sleep Onset (WASO) [ Time Frame: 21 days ]
Cortisol Awakening Response [ Time Frame: 8 nights ]

Central Contacts and Locations

Central contacts

Nicole Bowles, PhD

5034942541 circadian@ohsu.edu

Locations

OHSU

Recruiting

Portland, Oregon, United States, 97239

Contacts

Nicole Bowles, PhD

5034942541 circadian@ohsu.edu

More Information

Sponsor

Oregon Health and Science University

Last update posted

Oct 19, 2026

Last verified

Oct, 2026

Keywords

Sleep, slow wave
Polysomnography
Marijuana Abuse
Cannabinoids
Ecological Momentary Assessment
Sleep Duration

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-20. This information was provided to ClinicalTrials.gov by Oregon Health and Science University on 2026-10-19. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.