Recruiting

Nephrostomy Tube

Sponsor:

Brigham and Women's Hospital

Code:

NCT06987877

Conditions

Nephrostomy

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

No flushing of the nephrostomy

Flushing of nephrostomy

Study Details

Brief summary:

The investigators performing this research to study if routine flushing is necessary to prevent obstructions of a nephrostomy tube. This study will evaluate patients that have nephrostomy tube or will have nephrostomy tubes placed as part of their standard clinical care.

If participants agree to participate in this study, participants will undergo randomized assignment to either continue to routinely flush the nephrostomy tube with normal saline or not to routinely flush the nephrostomy tube with normal saline. Participantswill be in the study for approximately 3 months if they decide to stay for the whole study.

Conditions

Nephrostomy

Study ID

NCT06987877

Start date

Jan 1, 2026

Status verified date

Feb, 2026

Completion date

Mar 30, 2027

Anticipated

Primary completion date

Dec 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

• Age 18-80, with planned nephrostomy tube exchange or new nephrostomy tube placement with ongoing need for a nephrostomy tube.

Exclusion Criteria:

  • Current local infection
  • History of anaphylaxis to iodinated contrast
  • Pregnant or intent to become pregnant during the study
  • Irreversible coagulopathy
  • Planned for definitive treatment for the clinical indication of the nephrostomy tube prior to 12-week post-intervention.
  • Planned routine exchange prior to 12 weeks after nephrostomy tube exchange or placement procedure
  • Complete sensory loss below T10 dermatome.

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Routine Flushing of Nephrostomy

Subjects in the routine flushing group will continue to flush their nephrostomy tubes once per day with 10mL of normal saline

experimental: No Flushing of Nephrostomy

Subjects allocated to the study intervention group will not flush their nephrostomy tube during the duration of the research study

Interventions

No flushing of the nephrostomy

Subjects allocated to the study intervention group will not flush their nephrostomy tube during the duration of the research study

Flushing of nephrostomy

Subjects assigned to this cohort will flush their nephrostomy catheter once daily with 10 mL of normal saline

Primary outcome measure

  • Tube Obstruction [ Time Frame: 12 weeks ]

Central Contacts and Locations

Central contacts

Yan Epelboym, MD, MPH

617-732-4763yepelboym@bwh.harvard.edu

Austin Lai, MD

617-732-4763ALAI4@bwh.harvard.edu

Locations

Brigham and Women's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Yan Epelboym, MD, MPH

617-732-4763yepelboym@bwh.harvard.edu

yepelboym@bwh.harvard.edu

Principal Investigator:

Yan Epelboym, MD, MPH

More Information

Sponsor

Brigham and Women's Hospital

Last update posted

Feb 6, 2026

Last verified

Feb, 2026

Keywords

  • Nephrostomy occlusion

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Brigham and Women's Hospital on 2026-02-06.