Recruiting

Personalized Nutrition

Sponsor:

Stanford University

Code:

NCT06989164

Conditions

PreDiabetes

Diabetes Mellitus, Type 2

Healthy

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Post prandial testing

Study Details

Brief summary:

This study aims to understand why people respond differently to the same foods, especially when it comes to changes in blood sugar after eating. A continuous glucose monitors (CGMs) will be used to observe how individuals respond to specific meals and drinks (e.g., Oral Glucose Tolerance Test, OGTT). By studying these patterns, the investigators hope to identify different types of metabolism and see if certain foods or food ingredients (like fiber, amino acids, or vinegar) can help control blood sugar better for specific groups. This research will help lay the groundwork for personalized dietary advice based on a person's unique biology.

Conditions

PreDiabetes

Diabetes Mellitus, Type 2

Healthy

Study ID

NCT06989164

Start date

Oct 1, 2025

Status verified date

Nov, 2025

Completion date

Nov 30, 2028

Anticipated

Primary completion date

Nov 30, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • BMI (body mass index) >19 kg/m2 but < 45 kg/m2
  • HbA1c < or equal to 7.0% while not on antihyperglycemic medications
  • Be willing to provide written informed consent for all study procedures.
  • Able to commute to Stanford campus for on-site visits

Exclusion Criteria:

  • recent (<6mos) CVD (cardiovascular disease) event
  • active malignancy
  • kidney/liver disease
  • pregnancy/lactation
  • chronic inflammatory disease
  • eating disorder
  • bariatric surgery
  • history of acute pancreatitis
  • current use of antihyperglycemic, diabetogenic, or weight loss medications
  • heavy alcohol use
  • physical activity >2 hours/day
  • inability to come to Stanford CTRU (Clinical and Translational Research Unit) for metabolic testing

Study Design

Enrollment

100 participants

Anticipated

Intervention Model

Single group

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Diet Cycles

Participants will be asked to consume pre-portioned foods on different days as the first meal of the day, use a CGM, and take saliva and micro samples of blood before and after each meal.

Interventions

Post prandial testing

A variety of foods, supplements, and short prescriptive exercise will be tested to see which one helps mitigate the rise is postprandial glucose after eating carbohydrate containing foods.

Primary outcome measure

  • Post prandial peak glucose levels [ Time Frame: 3 hours ]
  • Post prandial glucose area under the curve (AUC) [ Time Frame: 3 hours ]

Central Contacts and Locations

Locations

Stanford University

Recruiting

Stanford, California, United States, 94304

Contacts

Sabrina Chun Johnston, MS, RD

(650) 725-0169csjohn@stanford.edu

More Information

Sponsor

Stanford University

Last update posted

Dec 2, 2025

Last verified

Nov, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-07. This information was provided to ClinicalTrials.gov by Stanford University on 2025-12-02.