Recruiting
Phase 3

Gabapentin

Sponsor:

Alliance for Clinical Trials in Oncology

Code:

NCT06992427

Conditions

Head and Neck Squamous Cell Carcinoma

Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8

Stage II Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8

Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8

Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Gabapentin

Placebo

Chemotheraphy

Radiation Therapy

Analgesic Agent

Study Details

Brief summary:

This phase III trial tests if gabapentin can prevent the need for opiate pain medication for mouth sores (oral mucositis) in patients undergoing treatment with chemotherapy and radiation for squamous cell carcinoma of the head and neck region. Oral mucositis is a common side effect of radiation treatment and can cause severe pain, dysphagia, and weight loss resulting in feeding tube placement, worse health-related quality of life, treatment interruptions, unplanned hospitalizations, and significant financial burden. Mucositis pain is often treated with opioid pain medications which do provide pain relief but have many known side effects not limited to mental clouding, constipation, fatigue, endocrinopathy, neurotoxicity, sleep-disordered breathing, and most distressingly persistent opioid use. Gabapentin may help relieve pain from oral mucositis caused by radiation while also reducing the need for opiate pain medications for patients receiving chemotherapy and radiation for squamous cell carcinoma of the head and neck region

Conditions

Head and Neck Squamous Cell Carcinoma

Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8

Stage II Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8

Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8

Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8

Study ID

NCT06992427

Start date

Jun 5, 2025

Status verified date

May, 2026

Completion date

Apr 15, 2031

Anticipated

Primary completion date

Aug 15, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Histologic documentation of disease: Squamous cell carcinoma of the head and neck region.

\* Stage: I-IV
  • No prior treatment for head and neck cancer
  • Planned treatment with cisplatin-based chemoradiation therapy (weekly or once every 3 weeks \[q 3 week\])
  • Able to swallow capsules whole
  • No known hypersensitivity to gabapentin or its ingredients
  • No patients on dialysis or with transplanted organs
  • No prior surgery or radiation for head and neck cancer and/or are being treated for recurrent head and neck cancer. Patients with a history of surgery and radioactive iodine for the treatment of thyroid cancer are eligible. Concurrent cancer therapy for other cancers is not allowed
  • No planned surgery or chemotherapy or immunotherapy following 7 weeks of standard chemoradiation treatment
  • No known brain metastases
  • No nonprescribed use of any opioids (including heroin) within 6 months prior to registration
  • No prescribed medications for chronic and/or long-term pain and/or neuropathy, including patients under treatment of a pain specialist or substance abuse programs. Acute post-biopsy medications are allowed if the patient has discontinued them 3 days prior to study registration
  • No current treatment with mefloquine
  • Age ≥ 18 years
  • Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2
  • Creatinine ≤ 1.5 x upper limit of normal (ULN)
  • Not pregnant and not nursing, because this study involves both radiation and chemotherapy. In addition, the genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown. Therefore, for women of childbearing potential, a negative pregnancy test done < 7 days prior to registration is required. Women must agree to using contraception for the duration of receiving study drugs and for 6 months after completing chemoradiation
  • Not taking medications for a psychotic psychiatric illness
  • No existing diagnosis of sleep apnea
  • No acute narrow-angle glaucoma
  • No uncontrolled concurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • No investigational agent within 30 days prior to registration
  • No enrollment on other studies of systemic pain control agents
  • Language: In order to complete the mandatory patient-completed measures, participants must be able to speak and read English or Spanish
  • Patients with impaired decision making are not eligible for study

Exclusion Criteria:

\-

Study Design

Enrollment

228 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

placebo comparator: Arm I (Placebo)

Starting by radiation treatment 8, patients receive placebo PO QD on day 1, BID on day 2, then TID starting day 3 onward. Patients also receive standard of care radiation, chemotherapy and pain medications. Treatment with placebo continues in the absence of disease progression or unacceptable toxicity, until the symptoms of oral mucositis and other treatment effects begin to resolve and other pain medications has been stopped. Patients then continue to receive placebo TID for 9 additional days, at sequentially smaller doses, then BID for 1 day and QD for one day before stopping. Patients undergo blood sample collection throughout the study.

experimental: Arm II (Gabapentin)

Starting by radiation treatment 8, patients receive gabapentin PO QD on day 1, BID on day 2, then TID starting day 3 onward. Patients also receive standard of care radiation, chemotherapy and pain medications. Treatment with gabapentin continues in the absence of disease progression or unacceptable toxicity, until the symptoms of oral mucositis and other treatment effects begin to resolve and other pain medications has been stopped. Patients then continue to receive gabapentin TID for 9 additional days, at sequentially smaller doses, then BID for 1 day and QD for one day before stopping. Patients undergo blood sample collection throughout the study.

Interventions

Gabapentin

Given PO

Placebo

Given PO

Chemotheraphy

Receive standard of care chemotherapy

Radiation Therapy

Undergo standard of care radiation

Analgesic Agent

Receive standard of care pain medication

Biospecimen Collection

Undergo blood sample collection

Survey Administration

Ancillary studies

Primary outcome measure

  • Need to use opioids during chemoradiation therapy (CRT) [ Time Frame: Up to 7 weeks ]

Central Contacts and Locations

Central contacts

Nancy Garcia

773-702-9171cancercontrolprotocols@alliancenctn.org

Locations

Arizona Center for Cancer Care - Gilbert

Recruiting

Gilbert, Arizona, United States, 85297

Contacts

Site Public Contact

480-278-8261penny.labriola@arizonaccc.com

Principal Investigator:

Cory W. Heal

Arizona Center for Cancer Care-Peoria

Recruiting

Peoria, Arizona, United States, 85381

Contacts

Site Public Contact

623-773-2873

Principal Investigator:

Cory W. Heal

Arizona Center for Cancer Care - Biltmore

Recruiting

Phoenix, Arizona, United States, 85016

Contacts

Site Public Contact

480-278-8261penny.labriola@arizonaccc.com

Principal Investigator:

Cory W. Heal

Arizona Center for Cancer Care - Phoenix

Recruiting

Phoenix, Arizona, United States, 85027

Contacts

Site Public Contact

480-278-8261penny.labriola@arizonaccc.com

Principal Investigator:

Cory W. Heal

Arizona Center for Cancer Care - Osborn

Recruiting

Scottsdale, Arizona, United States, 85251

Contacts

Site Public Contact

480-278-8261penny.labriola@arizonaccc.com

Principal Investigator:

Cory W. Heal

Arizona Center for Cancer Care - Scottsdale

Recruiting

Scottsdale, Arizona, United States, 85258

Contacts

Site Public Contact

480-278-8261penny.labriola@arizonaccc.com

Principal Investigator:

Cory W. Heal

Arizona Center for Cancer Care-Surprise

Recruiting

Surprise, Arizona, United States, 85374

Contacts

Site Public Contact

888-823-5923ctsucontact@westat.com

Principal Investigator:

Cory W. Heal

Arizona Center for Cancer Care

Recruiting

Tempe, Arizona, United States, 85284

Contacts

Site Public Contact

480-278-8261penny.labriola@arizonaccc.com

Principal Investigator:

Cory W. Heal

AIS Cancer Center at San Joaquin Community Hospital

Recruiting

Bakersfield, California, United States, 93301

Contacts

Site Public Contact

661-323-4673

Principal Investigator:

Luis Mariscal

Los Angeles General Medical Center

Recruiting

Los Angeles, California, United States, 90033

Contacts

Site Public Contact

323-865-0451uscnorrisinfo@med.usc.edu

Principal Investigator:

Adam Garsa

USC / Norris Comprehensive Cancer Center

Recruiting

Los Angeles, California, United States, 90033

Contacts

Site Public Contact

323-865-0451

Principal Investigator:

Adam Garsa

Kaiser Permanente-Franklin

Recruiting

Denver, Colorado, United States, 80205

Contacts

Site Public Contact

303-817-9295KPCOIHRClinicalResearch@kp.org

Principal Investigator:

Matthew J. Eadens

Kaiser Permanente-Rock Creek

Recruiting

Lafayette, Colorado, United States, 80026

Contacts

Site Public Contact

303-817-9295KPCOIHRClinicalResearch@kp.org

Principal Investigator:

Matthew J. Eadens

Saint Anthony Hospital

Recruiting

Lakewood, Colorado, United States, 80228

Contacts

Site Public Contact

720-874-1881ResearchInstituteInquiries@CommonSpirit.org

Principal Investigator:

Shahzad Siddique

Saint Luke's Cancer Institute - Boise

Recruiting

Boise, Idaho, United States, 83712

Contacts

Site Public Contact

208-381-2774eslinget@slhs.org

Principal Investigator:

Alison K. Conlin

Kootenai Health - Coeur d'Alene

Recruiting

Coeur d'Alene, Idaho, United States, 83814

Contacts

Site Public Contact

406-969-6060mccinfo@mtcancer.org

Principal Investigator:

John M. Schallenkamp

Saint Luke's Cancer Institute - Fruitland

Recruiting

Fruitland, Idaho, United States, 83619

Contacts

Site Public Contact

208-381-2774eslinget@slhs.org

Principal Investigator:

Alison K. Conlin

Saint Luke's Cancer Institute - Meridian

Recruiting

Meridian, Idaho, United States, 83642

Contacts

Site Public Contact

208-381-2774eslinget@slhs.org

Principal Investigator:

Alison K. Conlin

Saint Luke's Cancer Institute - Nampa

Recruiting

Nampa, Idaho, United States, 83687

Contacts

Site Public Contact

208-381-2774eslinget@slhs.org

Principal Investigator:

Alison K. Conlin

Kootenai Clinic Cancer Services - Post Falls

Recruiting

Post Falls, Idaho, United States, 83854

Contacts

Site Public Contact

406-969-6060mccinfo@mtcancer.org

Principal Investigator:

John M. Schallenkamp

Kootenai Clinic Cancer Services - Sandpoint

Recruiting

Sandpoint, Idaho, United States, 83864

Contacts

Site Public Contact

406-969-6060mccinfo@mtcancer.org

Principal Investigator:

John M. Schallenkamp

Advocate Outpatient Center - Aurora

Recruiting

Aurora, Illinois, United States, 60506

Contacts

Site Public Contact

ncorp@aah.org

Principal Investigator:

Thomas J. Saphner

Advocate Good Shepherd Hospital

Recruiting

Barrington, Illinois, United States, 60010

Contacts

Site Public Contact

847-842-4847

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Bloomington

Recruiting

Bloomington, Illinois, United States, 61704

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Canton

Recruiting

Canton, Illinois, United States, 61520

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Carthage

Recruiting

Carthage, Illinois, United States, 62321

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Advocate Illinois Masonic Medical Center

Recruiting

Chicago, Illinois, United States, 60657

Contacts

Site Public Contact

773-296-5360

Principal Investigator:

Thomas J. Saphner

AMG Crystal Lake - Oncology

Recruiting

Crystal Lake, Illinois, United States, 60014

Contacts

Site Public Contact

630-929-6129advocateresearch@advocate.com

Principal Investigator:

Thomas J. Saphner

Cancer Care Specialists of Illinois - Decatur

Recruiting

Decatur, Illinois, United States, 62526

Contacts

Site Public Contact

217-876-4762morganthaler.jodi@mhsil.com

Principal Investigator:

Bryan A. Faller

Decatur Memorial Hospital

Recruiting

Decatur, Illinois, United States, 62526

Contacts

Site Public Contact

217-876-4762morganthaler.jodi@mhsil.com

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Dixon

Recruiting

Dixon, Illinois, United States, 61021

Contacts

Site Public Contact

815-285-7800

Principal Investigator:

Bryan A. Faller

Advocate Good Samaritan Hospital

Recruiting

Downers Grove, Illinois, United States, 60515

Contacts

Site Public Contact

630-275-1270Barbara.barhamand@advocatehealth.com

Principal Investigator:

Thomas J. Saphner

Crossroads Cancer Center

Recruiting

Effingham, Illinois, United States, 62401

Contacts

Site Public Contact

217-876-4762morganthaler.jodi@mhsil.com

Principal Investigator:

Bryan A. Faller

Advocate Sherman Hospital

Recruiting

Elgin, Illinois, United States, 60123

Contacts

Site Public Contact

847-429-2907

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Eureka

Recruiting

Eureka, Illinois, United States, 61530

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Galesburg

Recruiting

Galesburg, Illinois, United States, 61401

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Advocate South Suburban Hospital

Recruiting

Hazel Crest, Illinois, United States, 60429

Contacts

Site Public Contact

708-799-9995

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Kewanee Clinic

Recruiting

Kewanee, Illinois, United States, 61443

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

AMG Libertyville - Oncology

Recruiting

Libertyville, Illinois, United States, 60048

Contacts

Site Public Contact

630-929-6129advocateresearch@advocatehealth.com

Principal Investigator:

Thomas J. Saphner

Condell Memorial Hospital

Recruiting

Libertyville, Illinois, United States, 60048

Contacts

Site Public Contact

630-929-6129advocateresearch@advocatehealth.com

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Macomb

Recruiting

Macomb, Illinois, United States, 61455

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Cancer Care Center of O'Fallon

Recruiting

O'Fallon, Illinois, United States, 62269

Contacts

Site Public Contact

217-876-4762morganthaler.jodi@mhsil.com

Principal Investigator:

Bryan A. Faller

HSHS Saint Elizabeth's Hospital

Recruiting

O'Fallon, Illinois, United States, 62269

Contacts

Site Public Contact

217-876-4762morganthaler.jodi@mhsil.com

Principal Investigator:

Bryan A. Faller

Advocate Christ Medical Center

Recruiting

Oak Lawn, Illinois, United States, 60453-2699

Contacts

Site Public Contact

800-323-8622

Principal Investigator:

Thomas J. Saphner

Advocate Outpatient Center - Oak Lawn

Recruiting

Oak Lawn, Illinois, United States, 60453

Contacts

Site Public Contact

ncorp@aah.org

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Ottawa Clinic

Recruiting

Ottawa, Illinois, United States, 61350

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Advocate High Tech Medical Park

Recruiting

Palos Heights, Illinois, United States, 60463

Contacts

Site Public Contact

ncorp@aah.org

Principal Investigator:

Thomas J. Saphner

Advocate Lutheran General Hospital

Recruiting

Park Ridge, Illinois, United States, 60068

Contacts

Site Public Contact

847-384-3621

Principal Investigator:

Thomas J. Saphner

Illinois CancerCare-Pekin

Recruiting

Pekin, Illinois, United States, 61554

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Peoria

Recruiting

Peoria, Illinois, United States, 61615

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Peru

Recruiting

Peru, Illinois, United States, 61354

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Illinois CancerCare-Princeton

Recruiting

Princeton, Illinois, United States, 61356

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Southern Illinois University School of Medicine

Recruiting

Springfield, Illinois, United States, 62702

Contacts

Site Public Contact

217-545-7929

Principal Investigator:

Bryan A. Faller

Springfield Clinic

Recruiting

Springfield, Illinois, United States, 62702

Contacts

Site Public Contact

800-444-7541

Principal Investigator:

Bryan A. Faller

Springfield Memorial Hospital

Recruiting

Springfield, Illinois, United States, 62781

Contacts

Site Public Contact

217-528-7541pallante.beth@mhsil.com

Principal Investigator:

Bryan A. Faller

Illinois CancerCare - Washington

Recruiting

Washington, Illinois, United States, 61571

Contacts

Site Public Contact

309-243-3605andersonj@illinoiscancercare.com

Principal Investigator:

Bryan A. Faller

Mary Greeley Medical Center

Recruiting

Ames, Iowa, United States, 50010

Contacts

Site Public Contact

515-956-4132

Principal Investigator:

Joseph J. Merchant

McFarland Clinic - Ames

Recruiting

Ames, Iowa, United States, 50010

Contacts

Site Public Contact

515-239-4734ksoder@mcfarlandclinic.com

Principal Investigator:

Joseph J. Merchant

Saint Luke's Hospital

Recruiting

Cedar Rapids, Iowa, United States, 52402

Contacts

Site Public Contact

319-368-5514Rachel.varner@unitypoint.org

Principal Investigator:

Candace R. Correa

Mercy Hospital

Recruiting

Cedar Rapids, Iowa, United States, 52403

Contacts

Site Public Contact

319-365-4673

Principal Investigator:

Deborah W. Wilbur

Oncology Associates at Mercy Medical Center

Recruiting

Cedar Rapids, Iowa, United States, 52403

Contacts

Site Public Contact

319-363-2690

Principal Investigator:

Deborah W. Wilbur

McFarland Clinic - Trinity Cancer Center

Recruiting

Fort Dodge, Iowa, United States, 50501

Contacts

Site Public Contact

515-956-4132

Principal Investigator:

Joseph J. Merchant

McFarland Clinic - Marshalltown

Recruiting

Marshalltown, Iowa, United States, 50158

Contacts

Site Public Contact

515-956-4132

Principal Investigator:

Joseph J. Merchant

Harold Alfond Center for Cancer Care

Recruiting

Augusta, Maine, United States, 04330

Contacts

Site Public Contact

207-626-4855

Principal Investigator:

Vatche Tchekmedyian

MaineHealth Coastal Cancer Treatment Center

Recruiting

Bath, Maine, United States, 04530

Contacts

Site Public Contact

773-702-9171protocols@AllianceNCTN.org

Principal Investigator:

Vatche Tchekmedyian

MaineHealth Cancer Care and IV Therapy - Brunswick

Recruiting

Brunswick, Maine, United States, 04011

Contacts

Site Public Contact

207-396-8670clinicalresearch@mainehealth.org

Principal Investigator:

Vatche Tchekmedyian

MaineHealth LincolnHealth Hospital

Recruiting

Damariscotta, Maine, United States, 04543

Contacts

Site Public Contact

207-396-8670clinicalresearch@mainehealth.org

Principal Investigator:

Vatche Tchekmedyian

MaineHealth Maine Medical Center - Portland

Recruiting

Portland, Maine, United States, 04102

Contacts

Site Public Contact

207-396-8670clinicalresearch@mainehealth.org

Principal Investigator:

Vatche Tchekmedyian

MaineHealth Cancer Care Center of York County

Recruiting

Sanford, Maine, United States, 04073

Contacts

Site Public Contact

207-459-1600

Principal Investigator:

Vatche Tchekmedyian

MaineHealth Maine Medical Center- Scarborough

Recruiting

Scarborough, Maine, United States, 04074

Contacts

Site Public Contact

207-396-8670clinicalresearch@mainehealth.org

Principal Investigator:

Vatche Tchekmedyian

MaineHealth Cancer Care and IV Therapy - South Portland

Recruiting

South Portland, Maine, United States, 04106

Contacts

Site Public Contact

207-396-8670clinicalresearch@mainehealth.org

Principal Investigator:

Vatche Tchekmedyian

Sanford Joe Lueken Cancer Center

Recruiting

Bemidji, Minnesota, United States, 56601

Contacts

Site Public Contact

218-333-5000OncologyClinicalTrialsFargo@sanfordhealth.org

Principal Investigator:

Daniel Almquist

Coborn Cancer Center at Saint Cloud Hospital

Recruiting

Saint Cloud, Minnesota, United States, 56303

Contacts

Site Public Contact

877-229-4907coborncancercenter@centracare.com

Principal Investigator:

Donald J. Jurgens

Saint Francis Medical Center

Recruiting

Cape Girardeau, Missouri, United States, 63703

Contacts

Site Public Contact

573-334-2230sfmc@sfmc.net

Principal Investigator:

Bryan A. Faller

Freeman Health System

Recruiting

Joplin, Missouri, United States, 64804

Contacts

Site Public Contact

417-347-4030LJCrockett@freemanhealth.com

Principal Investigator:

Jay W. Carlson

Mercy Hospital South

Recruiting

St Louis, Missouri, United States, 63128

Contacts

Site Public Contact

314-525-6042Danielle.Werle@mercy.net

Principal Investigator:

Jay W. Carlson

Mercy Hospital Saint Louis

Recruiting

St Louis, Missouri, United States, 63141

Contacts

Site Public Contact

314-251-7066

Principal Investigator:

Jay W. Carlson

Community Hospital of Anaconda

Recruiting

Anaconda, Montana, United States, 59711

Contacts

Site Public Contact

406-969-6060mccinfo@mtcancer.org

Principal Investigator:

John M. Schallenkamp

Billings Clinic Cancer Center

Recruiting

Billings, Montana, United States, 59101

Contacts

Site Public Contact

800-996-2663research@billingsclinic.org

Principal Investigator:

John M. Schallenkamp

Bozeman Health Deaconess Hospital

Recruiting

Bozeman, Montana, United States, 59715

Contacts

Site Public Contact

406-969-6060mccinfo@mtcancer.org

Principal Investigator:

John M. Schallenkamp

Benefis Sletten Cancer Institute

Recruiting

Great Falls, Montana, United States, 59405

Contacts

Site Public Contact

406-969-6060mccinfo@mtcancer.org

Principal Investigator:

John M. Schallenkamp

Logan Health Medical Center

Recruiting

Kalispell, Montana, United States, 59901

Contacts

Site Public Contact

406-969-6060mccinfo@mtcancer.org

Principal Investigator:

John M. Schallenkamp

Community Medical Center

Recruiting

Missoula, Montana, United States, 59804

Contacts

Site Public Contact

406-969-6060mccinfo@mtcancer.org

Principal Investigator:

John M. Schallenkamp

Nebraska Medicine-Bellevue

Recruiting

Bellevue, Nebraska, United States, 68123

Contacts

Site Public Contact

402-559-6941unmcrsa@unmc.edu

Principal Investigator:

Weining Zhen

Nebraska Methodist Hospital

Recruiting

Omaha, Nebraska, United States, 68114

Contacts

Site Public Contact

402-354-5144

Principal Investigator:

Tien-Shew W. Huang

Nebraska Medicine-Village Pointe

Recruiting

Omaha, Nebraska, United States, 68118

Contacts

Site Public Contact

402-559-5600

Principal Investigator:

Weining Zhen

University of Nebraska Medical Center

Recruiting

Omaha, Nebraska, United States, 68198

Contacts

Site Public Contact

402-559-6941unmcrsa@unmc.edu

Principal Investigator:

Weining Zhen

Jefferson Cherry Hill Hospital

Recruiting

Cherry Hill, New Jersey, United States, 08002

Contacts

Site Public Contact

215-600-9151ONCTrialNow@jefferson.edu

Principal Investigator:

Voichita Bar Ad

Sidney Kimmel Cancer Center Washington Township

Recruiting

Sewell, New Jersey, United States, 08080

Contacts

Site Public Contact

215-600-9151ONCTrialNow@jefferson.edu

Principal Investigator:

Voichita Bar Ad

Roswell Park Cancer Institute

Recruiting

Buffalo, New York, United States, 14263

Contacts

Site Public Contact

800-767-9355askroswell@roswellpark.org

Principal Investigator:

Anurag K. Singh

Northwell Health Physicians Partners Radiation Medicine at Queens

Recruiting

Forest Hills, New York, United States, 11375

Contacts

Site Public Contact

718-520-6620

Principal Investigator:

Bhupesh Parashar

Northwell Health/Center for Advanced Medicine

Recruiting

Lake Success, New York, United States, 11042

Contacts

Site Public Contact

516-734-8896

Principal Investigator:

Bhupesh Parashar

Manhattan Eye Ear and Throat Hospital

Recruiting

New York, New York, United States, 10065

Contacts

Site Public Contact

212-434-4460

Principal Investigator:

Bhupesh Parashar

Lenox Hill Hospital

Recruiting

New York, New York, United States, 10075

Contacts

Site Public Contact

516-734-8896

Principal Investigator:

Bhupesh Parashar

Queens Cancer Center

Recruiting

Rego Park, New York, United States, 11374

Contacts

Site Public Contact

718-312-3446

Principal Investigator:

Bhupesh Parashar

Stony Brook University Medical Center

Recruiting

Stony Brook, New York, United States, 11794

Contacts

Site Public Contact

800-862-2215

Principal Investigator:

Kartik M. Mani

Montefiore Medical Center-Einstein Campus

Recruiting

The Bronx, New York, United States, 10461

Contacts

Site Public Contact

718-379-6866eskwak@montefiore.org

Principal Investigator:

Rafi Kabarriti

Montefiore Medical Center - Moses Campus

Recruiting

The Bronx, New York, United States, 10467

Contacts

Site Public Contact

718-379-6866eskwak@montefiore.org

Principal Investigator:

Rafi Kabarriti

Sanford Bismarck Medical Center

Recruiting

Bismarck, North Dakota, United States, 58501

Contacts

Site Public Contact

701-323-5760OncologyClinicalTrialsFargo@sanfordhealth.org

Principal Investigator:

Daniel Almquist

Sanford Broadway Medical Center

Recruiting

Fargo, North Dakota, United States, 58122

Contacts

Site Public Contact

701-323-5760OncologyClinicalTrialsFargo@sanfordhealth.org

Principal Investigator:

Daniel Almquist

Sanford Roger Maris Cancer Center

Recruiting

Fargo, North Dakota, United States, 58122

Contacts

Site Public Contact

701-234-6161OncologyClinicalTrialsFargo@sanfordhealth.org

Principal Investigator:

Daniel Almquist

Aultman Health Foundation

Recruiting

Canton, Ohio, United States, 44710

Contacts

Site Public Contact

330-363-7274ClinicalReserachDept@aultman.com

Principal Investigator:

Jessica L. Wobb

University of Oklahoma Health Sciences Center

Recruiting

Oklahoma City, Oklahoma, United States, 73104

Contacts

Site Public Contact

405-271-8777ou-clinical-trials@ouhsc.edu

Principal Investigator:

Christina Henson

Geisinger Medical Center

Recruiting

Danville, Pennsylvania, United States, 17822

Contacts

Site Public Contact

570-271-5251HemonCCTrials@geisinger.edu

Principal Investigator:

Fiori Alite

Geisinger Cancer Center Dickson City

Recruiting

Dickson City, Pennsylvania, United States, 18519

Contacts

Site Public Contact

877-204-6081hemoncctrials@geisinger.edu

Principal Investigator:

Fiori Alite

UPMC Hillman Cancer Center Erie

Recruiting

Erie, Pennsylvania, United States, 16505

Contacts

Site Public Contact

412-864-7716ClinicalResearchServices@upmc.edu

Principal Investigator:

Dan P. Zandberg

Saint Vincent Hospital

Recruiting

Erie, Pennsylvania, United States, 16544

Contacts

Site Public Contact

814-452-5000

Principal Investigator:

Larisa Greenberg

UPMC Cancer Center at UPMC Horizon

Recruiting

Farrell, Pennsylvania, United States, 16121

Contacts

Site Public Contact

773-702-9171protocols@AllianceNCTN.org

Principal Investigator:

Dan P. Zandberg

UPMC Cancer Centers - Arnold Palmer Pavilion

Recruiting

Greensburg, Pennsylvania, United States, 15601

Contacts

Site Public Contact

724-838-1900

Principal Investigator:

Dan P. Zandberg

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Recruiting

Harrisburg, Pennsylvania, United States, 17109

Contacts

Site Public Contact

717-724-6765klitchfield@PINNACLEHEALTH.org

Principal Investigator:

Dan P. Zandberg

Jefferson Hospital

Recruiting

Jefferson Hills, Pennsylvania, United States, 15025

Contacts

Site Public Contact

412-359-3043ddefazio@wpahs.org

Principal Investigator:

Larisa Greenberg

Geisinger Medical Oncology-Lewisburg

Recruiting

Lewisburg, Pennsylvania, United States, 17837

Contacts

Site Public Contact

570-374-8555HemonCCTrials@geisinger.edu

Principal Investigator:

Fiori Alite

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Recruiting

Mechanicsburg, Pennsylvania, United States, 17050

Contacts

Site Public Contact

412-389-5208haneydl@upmc.edu

Principal Investigator:

Dan P. Zandberg

Forbes Hospital

Recruiting

Monroeville, Pennsylvania, United States, 15146

Contacts

Site Public Contact

412-858-7746

Principal Investigator:

Larisa Greenberg

UPMC Cancer Center - Monroeville

Recruiting

Monroeville, Pennsylvania, United States, 15146

Contacts

Site Public Contact

773-702-9171protocols@AllianceNCTN.org

Principal Investigator:

Dan P. Zandberg

UPMC Hillman Cancer Center - Monroeville

Recruiting

Monroeville, Pennsylvania, United States, 15146

Contacts

Site Public Contact

412-864-7716ClinicalResearchServices@upmc.edu

Principal Investigator:

Dan P. Zandberg

Thomas Jefferson University Hospital

Recruiting

Philadelphia, Pennsylvania, United States, 19107

Contacts

Site Public Contact

215-600-9151ONCTrialNow@jefferson.edu

Principal Investigator:

Voichita Bar Ad

Jefferson Torresdale Hospital

Recruiting

Philadelphia, Pennsylvania, United States, 19114

Contacts

Site Public Contact

215-600-9151ONCTrialNow@jefferson.edu

Principal Investigator:

Voichita Bar Ad

Allegheny General Hospital

Recruiting

Pittsburgh, Pennsylvania, United States, 15212

Contacts

Site Public Contact

877-284-2000

Principal Investigator:

Larisa Greenberg

University of Pittsburgh Cancer Institute (UPCI)

Recruiting

Pittsburgh, Pennsylvania, United States, 15232

Contacts

Site Public Contact

412-647-8073

Principal Investigator:

Dan P. Zandberg

UPMC-Shadyside Hospital

Recruiting

Pittsburgh, Pennsylvania, United States, 15232

Contacts

Site Public Contact

412-621-2334

Principal Investigator:

Dan P. Zandberg

UPMC-Saint Clair Hospital Cancer Center

Recruiting

Pittsburgh, Pennsylvania, United States, 15243

Contacts

Site Public Contact

412-502-3920

Principal Investigator:

Dan P. Zandberg

Geisinger Cancer Services-Pottsville

Recruiting

Pottsville, Pennsylvania, United States, 17901

Contacts

Site Public Contact

800-275-6401HemonCCTrials@geisinger.edu

Principal Investigator:

Fiori Alite

UPMC Cancer Center at UPMC Northwest

Recruiting

Seneca, Pennsylvania, United States, 16346

Contacts

Site Public Contact

814-676-7900

Principal Investigator:

Dan P. Zandberg

Wexford Health and Wellness Pavilion

Recruiting

Wexford, Pennsylvania, United States, 15090

Contacts

Site Public Contact

Dawnmarie.DeFazio@ahn.org

Principal Investigator:

Larisa Greenberg

Geisinger Wyoming Valley/Henry Cancer Center

Recruiting

Wilkes-Barre, Pennsylvania, United States, 18711

Contacts

Site Public Contact

570-271-5251HemonCCTrials@geisinger.edu

Principal Investigator:

Fiori Alite

Asplundh Cancer Pavilion

Recruiting

Willow Grove, Pennsylvania, United States, 19090

Contacts

Site Public Contact

215-600-9151ONCTrialNow@jefferson.edu

Principal Investigator:

Voichita Bar Ad

Gibbs Cancer Center-Pelham

Recruiting

Greer, South Carolina, United States, 29651

Contacts

Site Public Contact

864-560-6104kmertz-rivera@gibbscc.org

Principal Investigator:

Amarinthia (Amy) Curtis

Spartanburg Medical Center

Recruiting

Spartanburg, South Carolina, United States, 29303

Contacts

Site Public Contact

864-560-6104kmertz-rivera@gibbscc.org

Principal Investigator:

Amarinthia (Amy) Curtis

Sanford Cancer Center Oncology Clinic

Recruiting

Sioux Falls, South Dakota, United States, 57104

Contacts

Site Public Contact

605-312-3320OncologyClinicTrialsSF@sanfordhealth.org

Principal Investigator:

Daniel Almquist

Sanford USD Medical Center - Sioux Falls

Recruiting

Sioux Falls, South Dakota, United States, 57117-5134

Contacts

Site Public Contact

605-312-3320OncologyClinicalTrialsSF@SanfordHealth.org

Principal Investigator:

Daniel Almquist

Farmington Health Center

Recruiting

Farmington, Utah, United States, 84025

Contacts

Site Public Contact

888-424-2100cancerinfo@hci.utah.edu

Principal Investigator:

Ying J. Hitchcock

University of Utah Sugarhouse Health Center

Recruiting

Salt Lake City, Utah, United States, 84106

Contacts

Site Public Contact

888-424-2100cancerinfo@hci.utah.edu

Principal Investigator:

Ying J. Hitchcock

Huntsman Cancer Institute/University of Utah

Recruiting

Salt Lake City, Utah, United States, 84112

Contacts

Site Public Contact

888-424-2100cancerinfo@hci.utah.edu

Principal Investigator:

Ying J. Hitchcock

South Jordan Health Center

Recruiting

South Jordan, Utah, United States, 84009

Contacts

Site Public Contact

888-424-2100cancerinfo@hci.utah.edu

Principal Investigator:

Ying J. Hitchcock

United Hospital Center

Recruiting

Bridgeport, West Virginia, United States, 26330

Contacts

Site Public Contact

304-293-7374cancertrialsinfo@hsc.wvu.edu

Principal Investigator:

David A. Clump

WVUH-Berkely Medical Center

Recruiting

Martinsburg, West Virginia, United States, 25401

Contacts

Site Public Contact

304-293-7374cancertrialsinfo@hsc.wvu.edu

Principal Investigator:

David A. Clump

West Virginia University Healthcare

Recruiting

Morgantown, West Virginia, United States, 26506

Contacts

Site Public Contact

304-293-7374cancertrialsinfo@hsc.wvu.edu

Principal Investigator:

David A. Clump

Camden Clark Medical Center

Recruiting

Parkersburg, West Virginia, United States, 26101

Contacts

Site Public Contact

304-293-7374cancertrialsinfo@hsc.wvu.edu

Principal Investigator:

David A. Clump

Princeton Community Hospital

Recruiting

Princeton, West Virginia, United States, 24740

Contacts

Site Public Contact

304-487-7515

Principal Investigator:

David A. Clump

Wheeling Hospital/Schiffler Cancer Center

Recruiting

Wheeling, West Virginia, United States, 26003

Contacts

Site Public Contact

304-243-6442

Principal Investigator:

David A. Clump

Langlade Hospital and Cancer Center

Recruiting

Antigo, Wisconsin, United States, 54409

Contacts

Site Public Contact

715-623-9869Juli.Alford@aspirus.org

Principal Investigator:

Andrew J. Huang

Aurora Cancer Care-Southern Lakes VLCC

Recruiting

Burlington, Wisconsin, United States, 53105

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aurora Saint Luke's South Shore

Recruiting

Cudahy, Wisconsin, United States, 53110

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aurora Health Care Germantown Health Center

Recruiting

Germantown, Wisconsin, United States, 53022

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aurora Cancer Care-Grafton

Recruiting

Grafton, Wisconsin, United States, 53024

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aurora BayCare Medical Center

Recruiting

Green Bay, Wisconsin, United States, 54311

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aurora Cancer Care-Kenosha South

Recruiting

Kenosha, Wisconsin, United States, 53142

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Gundersen Lutheran Medical Center

Recruiting

La Crosse, Wisconsin, United States, 54601

Contacts

Site Public Contact

608-775-2385cancerctr@gundersenhealth.org

Principal Investigator:

Michael O. Ojelabi

Aurora Bay Area Medical Group-Marinette

Recruiting

Marinette, Wisconsin, United States, 54143

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aspirus Medford Hospital

Recruiting

Medford, Wisconsin, United States, 54451

Contacts

Site Public Contact

715-847-2353Beth.Knetter@aspirus.org

Principal Investigator:

Andrew J. Huang

Froedtert Menomonee Falls Hospital

Recruiting

Menomonee Falls, Wisconsin, United States, 53051

Contacts

Site Public Contact

262-257-5100

Principal Investigator:

Monica E. Shukla

Aurora Cancer Care-Milwaukee

Recruiting

Milwaukee, Wisconsin, United States, 53209

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aurora Saint Luke's Medical Center

Recruiting

Milwaukee, Wisconsin, United States, 53215

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Medical College of Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Site Public Contact

414-805-3666

Principal Investigator:

Monica E. Shukla

Aurora Sinai Medical Center

Recruiting

Milwaukee, Wisconsin, United States, 53233

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Drexel Town Square Health Center

Recruiting

Oak Creek, Wisconsin, United States, 53154

Contacts

Site Public Contact

414-805-0505

Principal Investigator:

Monica E. Shukla

Vince Lombardi Cancer Clinic - Oshkosh

Recruiting

Oshkosh, Wisconsin, United States, 54904

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aurora Cancer Care-Racine

Recruiting

Racine, Wisconsin, United States, 53406

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aspirus Cancer Care - James Beck Cancer Center

Recruiting

Rhinelander, Wisconsin, United States, 54501

Contacts

Site Public Contact

715-847-2353Beth.Knetter@aspirus.org

Principal Investigator:

Andrew J. Huang

Vince Lombardi Cancer Clinic-Sheboygan

Recruiting

Sheboygan, Wisconsin, United States, 53081

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aspirus Cancer Care - Stevens Point

Recruiting

Stevens Point, Wisconsin, United States, 54481

Contacts

Site Public Contact

715-847-2353Beth.Knetter@aspirus.org

Principal Investigator:

Andrew J. Huang

Aurora Medical Center in Summit

Recruiting

Summit, Wisconsin, United States, 53066

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Vince Lombardi Cancer Clinic-Two Rivers

Recruiting

Two Rivers, Wisconsin, United States, 54241

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aspirus Regional Cancer Center

Recruiting

Wausau, Wisconsin, United States, 54401

Contacts

Site Public Contact

877-405-6866

Principal Investigator:

Andrew J. Huang

Aurora Cancer Care-Milwaukee West

Recruiting

Wauwatosa, Wisconsin, United States, 53226

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Aurora West Allis Medical Center

Recruiting

West Allis, Wisconsin, United States, 53227

Contacts

Site Public Contact

414-302-2304ncorp@aurora.org

Principal Investigator:

Thomas J. Saphner

Froedtert West Bend Hospital/Kraemer Cancer Center

Recruiting

West Bend, Wisconsin, United States, 53095

Contacts

Site Public Contact

414-805-0505

Principal Investigator:

Monica E. Shukla

Aspirus Cancer Care - Wisconsin Rapids

Recruiting

Wisconsin Rapids, Wisconsin, United States, 54494

Contacts

Site Public Contact

715-422-7718

Principal Investigator:

Andrew J. Huang

More Information

Sponsor

Alliance for Clinical Trials in Oncology

Last update posted

May 11, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Alliance for Clinical Trials in Oncology on 2026-05-11.