Recruiting

Medical Marijuana

Sponsor:

Florida State University

Code:

NCT06995937

Conditions

Medical Cannabis

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Medical marijuana use among adults 50 and older has more than doubled in the past decade with exponential increases projected in this demographic by 2050, and prescription opioids are one of the most common treatments for pain management in this population. To date, no studies systematically assess driving performance in a rigorous and ecologically valid manner accounting for long-term medical marijuana use and/or the combined effect of prescription opioid use in adults 50 and older who endorse chronic or severe non-malignant pain. Further, studies examining how older adults self-regulate prescription medication use and driving behavior is limited, with none rigorously examining medical marijuana.

Conditions

Medical Cannabis

Study ID

NCT06995937

Start date

May 19, 2025

Status verified date

Aug, 2026

Completion date

Jan 30, 2029

Anticipated

Primary completion date

Jan 30, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age 50 and older who endorse chronic or severe non-malignant pain
  • Resident of Florida with an active and valid Florida Drivers License
  • Can communicate in English
  • Willing and able to complete study procedures
  • Have active medical marijuana card for >12 months issued by the state of Florida (MMG group) OR are race-sex match who has not used marijuana in the past 10 years with no history of daily use (NMG group)

Exclusion Criteria:

  • Have active psychosis
  • Have lost or revoked driving privileges
  • Score of below the cut 24 (out of 30) on the Montreal Cognitive Assessment (MoCA)
  • Are a control participant who urine test positive for marijuana use and/or reports any marijuana use in past 10 years

Study Design

Enrollment

250 participants

Anticipated

Interventions and Outcome Measures

Arms

Medical Marijuana Use (MMG)

Individuals aged 50 and older who report medical marijuana use >12 months daily or most days of the week

No Marijuana Exposure (NMG)

Individuals aged 50 and older who report no marijuana exposure past 10 years (race-sex matched to MMG group).

Primary outcome measure

  • Sum of Maneuvers Score (SMS) [ Time Frame: One Day ]

Central Contacts and Locations

Central contacts

Locations

University of Florida

Recruiting

Gainesville, Florida, United States, 32611

Contacts

Principal Investigator:

Hongwu Wang, PhD

Florida State University, Center for Translational Behavioral Science

Recruiting

Tallahassee, Florida, United States, 32310

Contacts

Principal Investigator:

Nicole Ennis, PhD

More Information

Sponsor

Florida State University

Last update posted

Aug 20, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Florida State University on 2026-08-20.