Recruiting

Proton Pump Inhibitors

Sponsor:

UCLA

Code:

NCT06998966

Conditions

Prescribing Patterns, Physician

Physician's Practice Patterns

Drug Utilization Review

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Interventions

Algorithmic Defaulting (Indication-Based Default)

Active Physician Choice

Study Details

Brief summary:

The proposed study is a quality improvement initiative designed to rigorously evaluate new variations of UCLA Health's proton pump inhibitor (PPI) order panels, building on internal quality improvement efforts to optimize prescribing workflows within the Electronic Health Record (EHR). PPIs are notoriously overprescribed, and the study team has identified that the CareConnect default prescription setting of 90 days with three refills (360 pill days) exceed standard guidelines (in most cases, 60 pill days). It is unclear whether this is the most appropriate workflow. Given that deprescribing PPIs carries minimal risk for most patients, this initiative will assess whether modifying defaulted prescription lengths influences prescribing behavior while ensuring physicians retain full decision-making authority.

This evaluation of PPI order panel variations is embedded within UCLA's existing EHR system, ensuring that changes are tested pragmatically within routine workflows. The study aims to determine whether small adjustments to the order panel can better align prescribing patterns with clinical best practices while maintaining physician autonomy.

Conditions

Prescribing Patterns, Physician

Physician's Practice Patterns

Drug Utilization Review

Study ID

NCT06998966

Start date

Jun, 2026

Status verified date

Apr, 2026

Completion date

Jun, 2027

Anticipated

Primary completion date

Apr, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • UCLA Health primary care physicians who have a clinical full-time equivalency of at least 25%.

Exclusion Criteria:

  • Physicians with a clinical full-time equivalency of less than 25%

Study Design

Enrollment

372 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

no intervention: Control

•Physicians use an unchanged prescribing workflow for Proton Pump Inhibitors (PPI) medications, with no changes to default dosage or duration.

experimental: Algorithmic Defaulting (Indication-Based Default)

The Electronic Health Record (EHR) automatically evaluates whether the patient at hand meets guideline criteria for long-term vs. short-term Proton Pump Inhibitors (PPI) use and it selects a default PPI prescription duration. (Providers can override the defaulted duration if they disagree with the automated assessment.) The order panel displays each PPI option below one of the following duration choices: For short-term PPI, this includes patients with conditions like Gastroesophageal reflux disease (GERD). For long-term PPI, this includes patients with conditions requiring extended therapy (e.g. Barrett's esophagus, chronic NSAID use)

experimental: Active Physician Choice

•The order panel displays each PPI option below one of the following duration choices: For short-term PPI, this includes patients with conditions like GERD. For long-term PPI, this includes patients with conditions requiring extended therapy (e.g. Barrett's esophagus, chronic NSAID use). The order panel removes the default selection, thus requiring providers to actively select a prescription duration for each patient, given the guideline education presented in the panel.

Interventions

Algorithmic Defaulting (Indication-Based Default)

PPIs are frequently overprescribed, and the CareConnect default prescription setting of 90 days with three refills (360 pill days) exceed standard guidelines (in most cases, 60 pill days). It is unclear whether this is the most appropriate workflow. Given that deprescribing PPIs carries minimal risk for most patients, this initiative will assess whether modifying defaulted prescription lengths influences prescribing behavior while ensuring physicians retain full decision-making authority.

Active Physician Choice

PPIs are frequently overprescribed, and the CareConnect default prescription setting of 90 days with three refills (360 pill days) exceed standard guidelines (in most cases, 60 pill days). It is unclear whether this is the most appropriate workflow. Given that deprescribing PPIs carries minimal risk for most patients, this initiative will assess whether requiring providers to actively select prescription lengths influences prescribing behavior while ensuring physicians retain full decision-making authority.

Primary outcome measure

  • Inappropriate Pill Days [ Time Frame: 12 months ]

Central Contacts and Locations

Central contacts

Katelyn Clinical Research Coordinator

310-267-5250katenguyen@mednet.ucla.edu

Locations

UCLA Health System

Recruiting

Los Angeles, California, United States, 90024

Contacts

Katelyn Clinical Research Coordinator

310-267-5250katenguyen@mednet.ucla.edu

More Information

Sponsor

University of California, Los Angeles

Last update posted

Apr 29, 2026

Last verified

Apr, 2026

Keywords

  • Proton Pump Inhibitors
  • Quality Improvement
  • Healthcare Utilization
  • Clinical Decision Support
  • resource utilization

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of California, Los Angeles on 2026-04-29.