Recruiting

Cardiac Arrest Care

Sponsor:

University of Pittsburgh

Code:

NCT07002294

Conditions

Cardiac Arrest (CA)

Heart Arrest

Heart Arrest, Out-Of-Hospital

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Transfer to specialty care

Usual care

Study Details

Brief summary:

This randomized clinical trial will determine if adult participants who are in the emergency department after being resuscitated from a cardiac arrest outside of the hospital benefit from care delivered at specialized centers.

The main question that it will answer is whether transferring participants to a hospital with a specialized cardiac arrest service improves recovery of function after 90 days.

Participants will receive all usual medical care, but some participants will be offered transfer to a regional cardiac arrest center and others will be offered care at the closest appropriate hospital. Investigators will interview participants after 90 days to assess their recovery.

Conditions

Cardiac Arrest (CA)

Heart Arrest

Heart Arrest, Out-Of-Hospital

Study ID

NCT07002294

Start date

May 11, 2026

Status verified date

Aug, 2026

Completion date

Jan, 2032

Anticipated

Primary completion date

Jun, 2031

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Out-of-hospital cardiac arrest
  • Resuscitated from cardiac arrest with palpable pulse in the emergency department
  • Treated at one of participating hospital emergency departments
  • Age ≥18 years

Exclusion Criteria:

  • Known prior advanced directives or decision to limit critical care
  • Known pre-arrest dependent functional status (e.g., living in a skilled nursing facility, hospice or bedbound)
  • Arrest in the emergency department >4 hours after arrival
  • Traumatic etiology of arrest
  • Known to have opted-out from the SPARC trial

Study Design

Enrollment

1618 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Transfer to specialty care

Participants randomized to receive specialty care will undergo immediate interfacility transport to and hospital treatment at the specialty care hospital

active comparator: Usual care

Participants randomized to the usual care arm will be hospitalized at the first hospital or transferred to the closest appropriate hospital

Interventions

Transfer to specialty care

Interfacility transport and treatment at the specialty care hospital

Usual care

Hospitalization and treatment at the closest appropriate facility

Primary outcome measure

  • Modified Rankin Scale [ Time Frame: 90 Days post arrest ]

Central Contacts and Locations

Central contacts

Sara DiFiore-Sprouse

4128642284difioresm@upmc.edu

Locations

University of Pittsburgh Department of Emergency Medicine

Recruiting

Pittsburgh, Pennsylvania, United States, 15213

Contacts

Sara DiFiore-Sprouse

4128642284difioresm@upmc.edu

Principal Investigator:

Jonathan Elmer, MD, MS

More Information

Sponsor

University of Pittsburgh

Last update posted

Aug 6, 2026

Last verified

Aug, 2026

Keywords

  • cardiac arrest

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Pittsburgh on 2026-08-06.